LAP (trifluoroacetate salt) |
| Catalog No.GC90564 |
An antiviral peptide
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lupus autoantigen peptide (LAP) is an antiviral peptide derived from La, an autoantigen found in patients with systemic lupus erythematosus (SLE), that corresponds to amino acids 11-28 of La.1 It inhibits the interaction between the hepatitis C virus (HCV) 5’-UTR and internal ribosome entry site (IRES) trans-acting factors (ITAFs), including polypyrimidine tract-binding protein (PTB) and poly(rC)-binding protein 2 (PCBP2).2 LAP (60 µM) inhibits HCV IRES-mediated translation in a reporter assay using Huh7 cells, an effect that can be reversed by recombinant PTB and PCBP2.1,2
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