Lj-1-60 |
| Catalog No.GB40262 |
Lj-1-60 is an ATP-competitive inhibitor targeting Fyn protein kinase. Lj-1-60 inhibited melanoma proliferation and induced cell cycle arrest into the G2/M phase and apoptosis by targeting Fyn/Stat3 pathway. Lj-1-60 markedly reduced cell viability in a time- and dose-dependent manner, with IC50 values of 1.65 µM (Sk-Mel-5) and 1.36 µM (Sk-Mel-28), respectively. Also, the IC50 value of Lj-1-60 in melanocyte cells PIG1 was 3.9 µM.
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Cas No.: 2414269-68-2
Sample solution is provided at 25 µL, 10mM.
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Lj-1-60 is an ATP-competitive inhibitor targeting Fyn protein kinase. Lj-1-60 inhibited melanoma proliferation and induced cell cycle arrest into the G2/M phase and apoptosis by targeting Fyn/Stat3 pathway. Lj-1-60 markedly reduced cell viability in a time- and dose-dependent manner, with IC50 values of 1.65 µM (Sk-Mel-5) and 1.36 µM (Sk-Mel-28), respectively. Also, the IC50 value of Lj-1-60 in melanocyte cells PIG1 was 3.9 µM.
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