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LJP 1586

Catalog No.GC70317

LJP 1586 is an amine-based inhibitor of semicarbazide-sensitive amine oxidase (SSAO) activity.

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LJP 1586 Chemical Structure

Cas No.: 955037-42-0

Size Price Stock Qty
1 mg
$199.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
LJP 1586 is an amine-based inhibitor of semicarbazide-sensitive amine oxidase (SSAO) activity. LJP 1586 is an orally active, potent and selective inhibitor of rodent and human SSAO activity, with IC50 values between 4 and 43 nM.

LJP 1586 (0-10mg/kg, orally) shows complete inhibition of rat lung SSAO, with an ED50 between 0.1 and 1 mg/kg, and a pharmacodynamic half-life of greater than 24 h[1].

References:
[1]. O'Rourke AM, et al. Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. J Pharmacol Exp Ther. 2008 Feb;324(2):867-75.

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