MAPK-IN-1 |
| Catalog No.GC70956 |
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2470587-69-8
Sample solution is provided at 25 µL, 10mM.
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MAPK-IN-1 (Compound 2) inhibits NO, IL-1β, IL-6, and TNF-α release in BV-2 cells with IC50 values of 0.49 ± 0.17, 1.34 ± 0.21, 9.17 ± 0.17 and 8.17 ± 0.23 μM, respectively[1].
MAPK-IN-1 downregulates LPS-induced phosphorylation of JNK, ERK, and p38 in MAPK signaling pathway[1].
MAPK-IN-1 inhibits expressions of iNOS, COX-2, and TLR4 in LPS-induced BV-2 cells[1].
References:
[1]. Wu JS, et al. The oxygenated products of cryptotanshinone by biotransformation with Cunninghamella elegans exerting anti-neuroinflammatory effects by inhibiting TLR 4-mediated MAPK signaling pathway. Bioorg Chem. 2020 Nov;104:104246.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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