Mca-PLGL-Dap(Dnp)-AR-NH2 (trifluoroacetate salt) (Synonyms: Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2, 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide) |
| Catalog No.GC47606 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Mca-PLGL-Dap(Dnp)-AR-NH2 is a fluorogenic peptide substrate for matrix metalloproteinases (MMPs).1 Upon cleavage by an MMP, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca has excitation and emission maxima of 328 and 420 nm, respectively.
1.Edkins, T.J., Alhadeff, J.A., Kwok, V., et al.Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeuticsJ. Pharm. Biomed. Anal.70408-414(2012)
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