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Murlentamab

Catalog No.GC72430

Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody.

Products are for research use only. Not for human use. We do not sell to patients.

Murlentamab Chemical Structure

Cas No.: 2058047-65-5

Size Price Stock Qty
1 mg
$315.00
In stock
5 mg
$819.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
Murlentamab (3C23K; GM102) is a humanized anti-AMHRII antibody. AMHRII is the anti-Müllerian hormone receptor. Murlentama significantly promotes macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC). Murlentama stimulates pro-inflammatory and anti-tumor internal environment, recruits and activates T cells. Murlentama suppresses tumors growth by inducing naïve macrophage orientation and promoting tumor-associated macrophage (TAM) reprogramming.

Murlentamab (20 mg/kg; i.v.; twice weekly for 4 weeks) inhibits tumor growth in mouse hepatocarcinoma PDX model in vivo[2].

References:
[1]. Prat M, et al. Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation. Cancers (Basel). 2021 Apr 13;13(8):1845.
[2]. Barret JM, et al. The Expression of Anti-Müllerian Hormone Type II Receptor (AMHRII) in Non-Gynecological Solid Tumors Offers Potential for Broad Therapeutic Intervention in Cancer. Biology (Basel). 2021 Apr 7;10(4):305.

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