N-desmethyl Trimipramine (Synonyms: Monodesmethyltrimipramine, Nortrimipramine) |
| Catalog No.GC49794 |
An active metabolite of trimipramine
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Cas No.: 2293-21-2
Sample solution is provided at 25 µL, 10mM.
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N-desmethyl Trimipramine is an active metabolite of the tricyclic antidepressant trimipramine .1 It inhibits the norepinephrine transporter (NET), serotonin (5-HT) transporter (SERT), and dopamine transporter (DAT; IC50s = 2.92, 6.22, and 29.5 µM, respectively) as well as organic cation transporter 1 (OCT1) and OCT2 (IC50s = 3.19 and 10.4 µM, respectively) in HEK293 cells expressing the human transporters.
1.Haenisch, B., Hiemke, C., and BÖnisch, H.Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transportersPsychopharmacology (Berl)217(2)289-295(2011)
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