Neuromedin S (rat) (trifluoroacetate salt) (Synonyms: NMS) |
| Catalog No.GC44378 |
Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively). Neuromedin S (1 nmol, i.c.v.) induces phase shifts in the circadian rhythm of locomotor activity in rats without altering the circadian period length. It also suppresses food and water intake in a dose-dependent manner when administered to rats during the dark period at doses ranging from 0.1 to 5 nmol. Co-administration of neuromedin S (1 nmol, i.c.v.) inhibits the ability of neuropeptide Y , ghrelin , and agouti-related protein (ARP) to stimulate food intake in rats by greater than 50%. Neuromedin S (0.2 nmol, i.c.v.) increases vasopressin levels in rat plasma within five minutes to levels five times greater than a saline control and decreases urinary volume by 25% during the dark period.
| Cas No. | SDF | ||
| Synonyms | NMS | ||
| Formula | C193H307N57O49S•XCF3COOH | M.Wt | 4241.9 |
| Solubility | Water: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.2357 mL | 1.1787 mL | 2.3574 mL |
| 5 mM | 0.0471 mL | 0.2357 mL | 0.4715 mL |
| 10 mM | 0.0236 mL | 0.1179 mL | 0.2357 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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