Oleandomycin (Synonyms: 4-Methylumbelliferyl α-D-galactoside) |
| Catalog No.GC10095 |
macrolide antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3922-90-5
Sample solution is provided at 25 µL, 10mM.
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Oleandomycin is an antibiotic produced by strains of Streptomyces.
In vitro: Oleandomycin has been identified as a macrolide antibiotic demonstrating antimicrobial activity similar to penicillin and erythromycin. In addition, oleandomycin structurally has a macrocyclic lactone ring of 14 carbon atoms with one sugar, oleandrose, and one amino sugar, desoxamine [1].
In vivo: The PK of oleandomycin after i.v. and po administration, both alone and after i.m. pretreatment with metamizole or dexamethasone, was studied in healthy dogs. Results showed that after i.v. injection of oleandomycin alone at 10 mg/kg, the t1/2β, Vd, Cl and AUC were 1.60 h, 1.11 L/kg, 7.36 ml/kg/min and 21.66 μg h/ml, respectively. There were no statistically significant differences following pretreatment with metamizole or dexamethasone. In addition, after po administration of oleandomycin alone, the t1/2β, Cmax, tmax), MAT and Fabs were 1.68 h, 5.34 μg/ml, 1.5 h, 1.34 h and 84.29%, respectively, and the pretreatment with metamizole showed a significantly decreased value for Cmax but the MAT was increased significantly. Statistically significant changes in the PK parameters of oleandomycin following po administration were also seen as a result of pretreatment with dexamethasone. The Cmax was increased and the tmax and MAT were lower [2].
Clinical trial: Up to now, oleandomycin is still in the preclinical development stage.
References:
[1] C. Vilches, C. Méndez, C. Hardisson, et al. Biosynthesis of oleandomycin by Streptomyces antibioticus: Influence of nutritional conditions and development of resistance. J.Gen.Microbiol. 136(8), 1447-1454 (1990).
[2] Milanova A, Lashev L. Pharmacokinetics of oleandomycin in dogs after intravenous or oral administration alone and after pretreatment with metamizole or dexamethasone. Vet Res Commun. 2002 Jan;26(1):61-71.
| Cas No. | 3922-90-5 | SDF | |
| Synonyms | 4-Methylumbelliferyl α-D-galactoside | ||
| Chemical Name | 7-(α-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one | ||
| Canonical SMILES | O=C1[C@@H]([C@H]([C@H]([C@H](OC([C@@H]([C@H]([C@@H]([C@H]([C@H](C[C@@]12CO2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@H](C4)OC)O)C)[H])C)=O)C)C)O)C | ||
| Formula | C35H61NO12 | M.Wt | 687.9 |
| Solubility | DMSO : 100 mg/mL (145.38 mM; Need ultrasonic); H2O : ≥ 12.5 mg/mL (18.17 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.4537 mL | 7.2685 mL | 14.537 mL |
| 5 mM | 0.2907 mL | 1.4537 mL | 2.9074 mL |
| 10 mM | 0.1454 mL | 0.7268 mL | 1.4537 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: ≥95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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