P110 (trifluoroacetate salt) |
| Catalog No.GC90607 |
A peptide inhibitor of DRP1
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
P110 is a peptide inhibitor of the mitochondrial GTPase dynamin-related protein 1 (DRP1).1 It selectively inhibits DRP1 GTPase activity over the additional mitochondrial GTPases OPA1, MFN1, and dynamin 1 at 1 µM. P110 (1 µM) inhibits the MPP+-induced protein-protein interaction between DRP1 and mitochondrial fission 1 (FIS1), as well as MPP+-, carbonyl cyanide M-chloro phenyl drazone-, rotenone-, or drogen peroxide-induced DRP1 translocation to the mitochondria in SH-SY5Y cells. It also inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *