Perfluorooctanesulfonic Acid |
| Catalog No.GC90582 |
A perfluoroalkyl substance
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1763-23-1
Sample solution is provided at 25 µL, 10mM.
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Perfluorooctanesulfonic acid (PFOS) is a perfluoroalkyl substance (PFAS).1 It decreases peroxisome proliferator-activated receptor γ (PPARγ) transactivation in a reporter assay and induces apoptosis in NRK-52E rat renal proximal tubular epithelial cells, effects that can be reversed by the PPARγ agonist rosiglitazone , when used at a concentration of 50 nM. PFOS (20 mg/L) increases malondialdede (MDA) levels and decreases glutathione (GSH) levels in zebrafish larvae.2 It decreases body weight and induces hepatomegaly, renal pertrop, neoplastic growth in the gonads, thickening of pulmonary epithelial walls, and focal perplasia of cerebral gliocytes in rats when administered at a dose of 20 mg/kg.3 Maternal serum exposure to PFOS is positively associated with gestational diabetes, and umbilical cord serum levels are negatively associated with infant birth weight and head circumference.4,5 It has been found in lake trout (S. namaycush), marine mammals, and urban watersheds.6,7,8
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