PFM03 |
| Catalog No.GC71014 |
PFM03 is a MRE11 Endonuclease inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1558598-48-3
Sample solution is provided at 25 µL, 10mM.
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PFM03 (50-400 μM; 30 min) specifically inhibits MRE11 endonuclease activity[1].
PFM03 (100 μM; 30 min) causes normal DSB repair in G2 (CENPF+) cells[1].
PFM03 (50 μM; 8 h) enhances NHEJ usage but reduces homologous recombination (HR) in cells[1].
References:
[1]. Shibata A, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53(1):7-18.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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