Poly-D-lysine hydrobromide (M.W 30000~70000) |
| Catalog No.GC19972 |
Poly-D-lysine hydrobromide is a cell non-specific attachment factor that is often used to promote cell adhesion to solid substrates.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27964-99-4
Sample solution is provided at 25 µL, 10mM.
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Poly-D-lysine hydrobromide (M.W 30000~70000) is a cell non-specific attachment factor that is often used to promote the adhesion of cells to solid matrices[1]. Poly-D-lysine hydrobromide is a synthetic polypeptide composed of D-type lysine residues linked by peptide bonds to form a polymer, and each lysine residue contains approximately one HBr [2]. HBr interferes with hydrogen bonds between amino and carboxyl groups [3]. Poly-D-lysine hydrobromide increases the number of positively charged cell binding sites [4]. Poly-D-lysine hydrobromide can be used as a matrix material to help cells grow in 3D structures [5]. The molecular weight of this product is 30000~70000.
References:
[1]Liu S, Tian H, Niu Y, et al. Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury: Axonal regeneration and synaptogenesis mediate neural repair in TBI[J]. Acta biochimica et biophysica Sinica, 2022, 54(9): 1289.
[2]Manouchehri S, Zarrintaj P, Saeb M R, et al. Advanced delivery systems based on lysine or lysine polymers[J]. Molecular Pharmaceutics, 2021, 18(10): 3652-3670.
[3]Sajan D, Joseph L, Vijayan N, et al. Natural bond orbital analysis, electronic structure, non-linear properties and vibrational spectral analysis of L-histidinium bromide monohydrate: a density functional theory[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011, 81(1): 85-98.
[4] Marukovich N I, Nesterenko A M, Ermakov Y A. Structural factors of lysine and polylysine interaction with lipid membranes[J]. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 2015, 9: 40-47.
[5]Worthington K S, Do A V, Smith R, et al. Two‐photon polymerization as a tool for studying 3D printed topography‐induced stem cell fate[J]. Macromolecular bioscience, 2019, 19(2): 1800370.
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