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PPPDA-O16B

Catalog No.GC91807

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.

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PPPDA-O16B Chemical Structure

Cas No.: N/A

Size Price Stock Qty
5 mg
$165.00
In stock
10 mg
$314.00
In stock
25 mg
$743.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.[1] LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.

References:
[1].Li, W., Shao, L., Liu, J., et al.Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticlesBiomater. Sci.11(9)3172-3179(2023).

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