Home>>(R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

(R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

Catalog No.GC91254

A homolog of EPEA

Products are for research use only. Not for human use. We do not sell to patients.

(R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide Chemical Structure

Size Price Stock Qty
1 mg
$114.00
In stock
5 mg
$503.00
In stock
10 mg
$893.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Eicosapentaenoyl ethanolamide (EPEA) has potential signaling roles in aging, cancer, inflammation, and neurological development.1,2,3,4 At least some of EPEA’s effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists.5,1 R-(+)-Eicosapentaenyl-1’-droxy-2’-propylamide is a homolog of EPEA, characterized by the addition of an (R)-α-metl group at the metlene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide to produce R-1 methanandamide imparts higher affinity for the CB receptor as well as improved metabolic stability.6 The psiological actions of this compound have not been evaluated.

Chemical Properties of (R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

Cas No. SDF
Formula C23H37NO2 M.Wt 359.6
Solubility DMF: 11 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7809 mL 13.9043 mL 27.8087 mL
5 mM 0.5562 mL 2.7809 mL 5.5617 mL
10 mM 0.2781 mL 1.3904 mL 2.7809 mL
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of (R)-(+)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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