Amarogentin |
| Catalog No.GC42776 |
A secoiridoid glycoside with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21018-84-8
Sample solution is provided at 25 µL, 10mM.
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Amarogentin is a secoiridoid glycoside that has been found in Swertia and has diverse biological activities, including anticancer, antidiabetic, and anti-leishmanial properties. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 µM after 48 hours) and increases apoptosis when used at a concentration of 50 µM. Amarogentin (10-50 mg/kg, s.c.) dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. It reduces plasma glucose levels in a rat model of diabetes induced by streptozotocin in a dose-dependent manner and reverses the STZ-induced increase in soleus muscle levels of glucose transporter 4 (Glut4) when administered at a dose of 0.5 mg/kg. Amarogentin reduces parasite burden in the spleen of hamsters infected with L. donovani in a dose-dependent manner.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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