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Home >> Signaling Pathways >> Angiogenesis

Angiogenesis

Products for  Angiogenesis

  1. Cat.No. Product Name Information
  2. GC11753 P11 P11 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM). P11 Chemical Structure
  3. GC11951 PAR 4 (1-6)

    GYPGQV

    PAR4 agonist

     PAR 4 (1-6) Chemical Structure
  4. GC62101 PAR-2-IN-1 PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects. PAR-2-IN-1 Chemical Structure
  5. GA23350 PAR-3 (1-6) amide (human) PAR-3 (1-6) amide (human) is a proteinase-activated receptor (PAR-3) agonist peptide. PAR-3 (1-6) amide (human) Chemical Structure
  6. GC33599 PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA))

    PAR-4-AP TFA; AY-NH2 TFA

     PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) Chemical Structure
  7. GC15817 PAR-4 Agonist Peptide, amide (AY-NH2)

    PAR-4-AP; AY-NH2

     PAR-4 Agonist Peptide, amide(AY-NH2) (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. PAR-4 Agonist Peptide, amide (AY-NH2) Chemical Structure
  8. GC38134 Parmodulin 2 Reversible inhibitor of PAR1mediated platelet activation Parmodulin 2 Chemical Structure
  9. GC69663 Parstatin(mouse) TFA

    Parstatin (mouse) TFA is a peptide agonist of the PAR-1 thrombin receptor with cell-penetrating properties and an effective inhibitor of angiogenesis.

     Parstatin(mouse) TFA Chemical Structure
  10. GC40085 Pazopanib-d6 Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib-d6 Chemical Structure
  11. GC36861 PCI 29732 A multi-kinase inhibitor PCI 29732 Chemical Structure
  12. GC13812 PCI-32765 (Ibrutinib)

    Imbruvica, PCI 32765

     PCI-32765 (Ibrutinib) is an irreversible selective inhibitor of Bruton s tyrosine kinase (BTK) that selectively targets its kinase domain and modulates BTK downstream signaling by reducing its phosphorylating capacity with IC50 of 0.5 nM in cell-free assays. PCI-32765 (Ibrutinib) Chemical Structure
  13. GC12921 PCI-32765 Racemate PCI-32765 Racemate (PCI-32765 Racemate) is the racemate of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. PCI-32765 Racemate Chemical Structure
  14. GC30155 PCI-33380 PCI-33380 is an irreversible and selective Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe). PCI-33380 Chemical Structure
  15. GC44584 PD 168368 PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors (Kis = 15-45 nM for rat and human receptors expressed in various cell lines). PD 168368 Chemical Structure
  16. GC34709 PF-06250112 PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. PF-06250112 Chemical Structure
  17. GC62515 Pirtobrutinib

    LOXO-305, LY3527727

     Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM. Pirtobrutinib Chemical Structure
  18. GC10235 Plinabulin (NPI-2358)

    NPI-2358

     Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. Plinabulin (NPI-2358) Chemical Structure
  19. GC67708 PLN-1474 PLN-1474 Chemical Structure
  20. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5 Chemical Structure
  21. GC47966 PPACK (trifluoroacetate salt)

    Pebac, DPhenylalanylprolylarginyl Chloromethyl Ketone

     An antithrombin peptide PPACK (trifluoroacetate salt) Chemical Structure
  22. GC31339 PRN1008

    PRN1008

     PRN1008 (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton's Tyrosine Kinase (BTK), with an IC50 of 1.3 nM. PRN1008 Chemical Structure
  23. GC47980 Propionyl-L-carnitine-d3 (chloride)

    C3:0 Carnitine-d3, CAR 3:0-d3, L-Carnitine propionyl ester-d3, Levocarnitine propionate-d3, L-Propionylcarnitine-d3

    An internal standard for the quantification of propionyl-L-carnitine

     Propionyl-L-carnitine-d3 (chloride) Chemical Structure
  24. GC69768 Protease-Activated Receptor-1, PAR-1 Agonist

    Protease-Activated Receptor-1, PAR-1 Agonist is a selective peptide that activates Protease-Activated Receptor-1 (PAR-1), which corresponds to the PAR1 ligand and selectively mimics the action of thrombin through this receptor.

     Protease-Activated Receptor-1, PAR-1 Agonist Chemical Structure
  25. GC62469 Protease-Activated Receptor-1, PAR-1 Agonist TFA Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor. Protease-Activated Receptor-1, PAR-1 Agonist TFA Chemical Structure
  26. GC61456 Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide. Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Chemical Structure
  27. GC33429 Protease-Activated Receptor-4 Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Protease-Activated Receptor-4 Chemical Structure
  28. GC49873 Protectin D1 methyl ester

    Neuroprotectin D1 methyl ester, NPD1 methyl ester, PD1 methyl ester

     An esterified form of protectin D1 Protectin D1 methyl ester Chemical Structure
  29. GC32680 PT-2385 PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM. PT-2385 Chemical Structure
  30. GC37034 PT2977

    PT2977; MK-6482

     PT2977 (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). PT2977 Chemical Structure
  31. GC60311 PTUPB PTUPB is a novel dual COX-2 and sEH inhibitor with IC50 values of 1.26 nM and 0.9 μM, respectively. PTUPB Chemical Structure
  32. GC11031 PX-478 2HCl

    PX-478 is a selective inhibitor that suppresses constitutive and hypoxia-induced HIF-1α levels.

     PX-478 2HCl Chemical Structure
  33. GC37048 QL47 QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 Chemical Structure
  34. GC49221 QLT0267 An ILK inhibitor QLT0267 Chemical Structure
  35. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist Quininib Chemical Structure
  36. GC37066 Rac-PT2399 A potent and specific HIF-2α inhibitor Rac-PT2399 Chemical Structure
  37. GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib-13C-d3 Chemical Structure
  38. GC38375 Remibrutinib Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib Chemical Structure
  39. GC10184 RGD (Arg-Gly-Asp) Peptides RGD (Arg-Gly-Asp) Peptides is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. RGD (Arg-Gly-Asp) Peptides Chemical Structure
  40. GC37524 RGD peptide (GRGDNP) TFA RGD peptide (GRGDNP) TFA Chemical Structure
  41. GC34402 RGD Trifluoroacetate RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins. RGD Trifluoroacetate Chemical Structure
  42. GC16385 RGDS peptide

    Fibronectin Inhibitor, HArgGlyAspSerOH

     RGDS peptide is an integrin binding sequence that inhibits integrin receptor function. RGDS peptide Chemical Structure
  43. GC45798 Rhein-13C4

    Rheic Acid-13C4

    An internal standard for the quantification of rhein

     Rhein-13C4 Chemical Structure
  44. GC37541 Risuteganib Risuteganib Chemical Structure
  45. GC17991 RLLFT-NH2 Protease-activated receptor agonist RLLFT-NH2 Chemical Structure
  46. GC11230 RN486 Btk inhibitor,potent and selective RN486 Chemical Structure
  47. GC62397 RO0270608 RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. RO0270608 Chemical Structure
  48. GC72461 Rovelizumab Rovelizumab is a humanized monoclonal leukointegrin antibody. Rovelizumab Chemical Structure
  49. GC14795 RWJ 50271 LFA-1/sICAM interaction inhibitor RWJ 50271 Chemical Structure
  50. GC61777 RWJ-56110 dihydrochloride RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride Chemical Structure
  51. GC14143 SB273005

    An αvβ3 antagonist

     SB273005 Chemical Structure
  52. GC10291 SCH 79797 dihydrochloride PAR1 receptor antagonist SCH 79797 dihydrochloride Chemical Structure
  53. GC63540 SCH79797 SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 Chemical Structure
  54. GC64571 Sibrafiban

    RO 48-3657

     Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban Chemical Structure
  55. GC49713 SIKVAV (acetate)

    Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val

     A laminin α1-derived peptide SIKVAV (acetate) Chemical Structure
  56. GC49358 Sildenafil Chlorosulfonyl

    CMP

     An intermediate in the synthesis of sildenafil Sildenafil Chlorosulfonyl Chemical Structure
  57. GC48078 Sildenafil-d3 An internal standard for the quantification of sildenafil Sildenafil-d3 Chemical Structure
  58. GC62614 SJF620 hydrochloride SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. SJF620 hydrochloride Chemical Structure
  59. GC14540 SLIGKV-NH2 SLIGKV-NH2 (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. SLIGKV-NH2 Chemical Structure
  60. GC17514 SLIGRL-NH2

    Protease-Activated Receptor-2 Activating Peptide

     PAR2 activator SLIGRL-NH2 Chemical Structure
  61. GC37672 Spebrutinib besylate

    AVL-292 benzenesulfonate; CC-292 besylate

     Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s) in biochemical assays. Spebrutinib besylate Chemical Structure
  62. GC40963 Spirolaxine Spirolaxine is a long-chain phthalide produced by the fungus S. Spirolaxine Chemical Structure
  63. GC31993 SR121566A SR121566A is a novel non-peptide Glycoprotein IIb/IIIa (GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively. SR121566A Chemical Structure
  64. GC44956 Streptochlorin

    SF 2583A

     Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. Streptochlorin Chemical Structure
  65. GC45688 STX140

    2-Methoxyestradiol-bis-sulphamate

     An estrogen sulfamate STX140 Chemical Structure
  66. GC44966 Sucrose octasulfate (potassium salt)

    SOS, Sucrosofate potassium

     Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate (potassium salt) Chemical Structure
  67. GC32876 SYP-5 A HIF-1 inhibitor SYP-5 Chemical Structure
  68. GC64120 TAK-020 TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. TAK-020 Chemical Structure
  69. GC12037 TC-I 15 α2β1 integrin inhibitor TC-I 15 Chemical Structure
  70. GC18025 TCS 2314 integrin very late antigen-4 (VLA-4; α4β1) antagonist TCS 2314 Chemical Structure
  71. GC61316 tcY-NH2 TFA

    (trans-Cinnamoyl)-YPGKF-NH2 TFA

     tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA Chemical Structure
  72. GC61323 Tetrac Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities. Tetrac Chemical Structure
  73. GC17444 TFLLR-NH2 PAR1 selective agonist TFLLR-NH2 Chemical Structure
  74. GC37770 TFLLR-NH2(TFA) TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. TFLLR-NH2(TFA) Chemical Structure
  75. GP10085 Thrombin Receptor Activator for Peptide 5 (TRAP-5)

    H2N-Ser-Phe-Leu-Leu-Arg-OH

    Thrombin Receptor Activator for Peptide 5 (TRAP-5) Chemical Structure
  76. GC10140 Thrombin Receptor Agonist Peptide Thrombin Receptor Agonist Peptide is a synthetic thrombin receptor agonist peptide. Thrombin Receptor Agonist Peptide Chemical Structure
  77. GC32945 THS-044 THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. THS-044 Chemical Structure
  78. GC45054 Tie2 Inhibitor 7 Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. Tie2 Inhibitor 7 Chemical Structure
  79. GC32228 Tilorone dihydrochloride

    NSC 143969

     An interferon-inducing antiviral agent Tilorone dihydrochloride Chemical Structure
  80. GC33821 Tirabrutinib (ONO-4059)

    GS-4059, ONO-WG-307, Tirabrutinib

     Tirabrutinib (ONO-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib (ONO-4059) Chemical Structure
  81. GC34097 Tirabrutinib hydrochloride (ONO-4059 (hydrochloride))

    GS-4059, ONO-WG-307

     Tirabrutinib (ONO-4059) hydrochloride is an orally active Bruton's Tyrosine Kinase (BTK) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib hydrochloride (ONO-4059 (hydrochloride)) Chemical Structure
  82. GC13255 Tirofiban selective platelet GPIIb/IIIa antagonist Tirofiban Chemical Structure
  83. GC11371 Tirofiban hydrochloride monohydrate A GPIIb/IIIa antagonist Tirofiban hydrochloride monohydrate Chemical Structure
  84. GC63229 TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively. TL-895 Chemical Structure
  85. GC37801 TM6089 TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. TM6089 Chemical Structure
  86. GC63232 Tolebrutinib

    SAR442168; PRN2246

     Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib Chemical Structure
  87. GC31498 TP0463518

    TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor

     TP0463518 Chemical Structure
  88. GC37818 TR-14035 TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035 Chemical Structure
  89. GC48195 trans-trismethoxy Resveratrol-d4

    (E)-5-2-(4-hydroxyphenyl)ethenyl-1,3-benzene diol-d4, TMS-d4, trans-3,5,4'-Trimethoxystilbene-d4

     An internal standard for the quantification of trans-trismethoxy resveratrol trans-trismethoxy Resveratrol-d4 Chemical Structure
  90. GC11662 TRAP-6

    PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6

    PAR1 agonist

     TRAP-6 Chemical Structure
  91. GC65529 TRAP-6 amide TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. TRAP-6 amide Chemical Structure
  92. GC48210 TRX-818 (sodium salt) An anticancer compound TRX-818 (sodium salt) Chemical Structure
  93. GC37852 UDM-001651 UDM-001651 is a potent, selective, and orally bioavailable protease-activated receptor 4 (PAR4) antagonist (IC50=4 nM; Kd=1.4 nM). UDM-001651 Chemical Structure
  94. GC16811 Vadadustat

    AKB6548, PG-1016548

     HIF-PH inhibitor Vadadustat Chemical Structure
  95. GC63490 Valategrast

    R-411 free base

     Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast Chemical Structure
  96. GC64212 Valategrast hydrochloride

    R-411

     Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride Chemical Structure
  97. GC45769 Vandetanib-d6

    ZD6474-d6

     An internal standard for the quantification of vandetanib Vandetanib-d6 Chemical Structure
  98. GC37889 VCE-004.8

    VCE-?004.8

     VCE-004.8 (VCE-004.8) is an orally active, specific PPARγ and CB2 receptor dual agonist. VCE-004.8 Chemical Structure
  99. GC34077 Vecabrutinib (SNS-062) Vecabrutinib (SNS-062) (SNS-062) is a potent, noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2 nM, respectively. Vecabrutinib (SNS-062) shows an IC50 of 24 nM for ITK. Vecabrutinib (SNS-062) Chemical Structure
  100. GC34211 Vedolizumab Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease. Vedolizumab Chemical Structure
  101. GC11727 VKGILS-NH2 control peptide for SLIGKV-NH2, PAR1 agonist VKGILS-NH2 Chemical Structure

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