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Home >> Signaling Pathways >> Apoptosis >> p53

p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

Products for  p53

  1. Cat.No. Product Name Information
  2. GC42586 6α-hydroxy Paclitaxel

    6α-hydroxy Taxol

     6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel, produced by the action of the cytochrome P450 isoform CYP2C8. 6α-hydroxy Paclitaxel Chemical Structure
  3. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid

    αEleostearic Acid, αESA, LAF 237

     9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid Chemical Structure
  4. GC40785 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester

    αESA ethyl ester, Ethyl αeleostearate

     9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester Chemical Structure
  5. GC40710 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester

    αESA methyl ester, Methyl αeleostearate

     9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester Chemical Structure
  6. GC65880 ADH-6 TFA ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases. ADH-6 TFA Chemical Structure
  7. GC33356 AM-8735 AM-8735 is a potent and selective MDM2 inhibitor with an IC50 of 25 nM. AM-8735 Chemical Structure
  8. GC15828 AMG232

    AMG 232;AMG-232

     AMG232 (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. AMG232 binds to MDM2 with a Kd of 0.045 nM. AMG232 Chemical Structure
  9. GC42785 Amifostine (hydrate)

    Ethyol, WR 2721

     Amifostine (hydrate) (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine (hydrate) selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine (hydrate) is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine (hydrate) protects cells from damage by scavenging oxygen-derived free radicals. Amifostine (hydrate) reduces renal toxicity and has antiangiogenic action. Amifostine (hydrate) Chemical Structure
  10. GC61804 Amifostine thiol Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine. Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway. Amifostine thiol Chemical Structure
  11. GC35367 APG-115

    AA-115

     APG-115 (APG-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. APG-115 blocks the interaction of MDM2 and p53 and induces cell-cycle arrest and apoptosis in a p53-dependent manner. APG-115 Chemical Structure
  12. GC18136 BH3I-1

    BHI1; BH 3I1

     Bcl-2 or Bcl-XL inhibitor BH3I-1 Chemical Structure
  13. GC35511 BI-0252 BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis. BI-0252 Chemical Structure
  14. GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 Chemical Structure
  15. GC43190 CAY10682 (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 Chemical Structure
  16. GC14634 CBL0137

    CBLC137,Curaxin 137

     curaxin that activates p53 and inhibits NF-κB CBL0137 Chemical Structure
  17. GC15394 CBL0137 (hydrochloride)

    CBLC137,Curaxin 137

    curaxin that activates p53 and inhibits NF-κB

     CBL0137 (hydrochloride) Chemical Structure
  18. GC43239 Chk2 Inhibitor

    SC-203885

     Chk2 Inhibitor (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2 Inhibitor can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect. Chk2 Inhibitor Chemical Structure
  19. GC64649 Cjoc42 Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage. Cjoc42 Chemical Structure
  20. GC43297 Coenzyme Q2

    CoQ2, Ubiquinone-2, Ubiquinone Q2

     Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. Coenzyme Q2 Chemical Structure
  21. GC15225 COTI-2 activates mutant forms of p53 COTI-2 Chemical Structure
  22. GC15840 CP 31398 dihydrochloride A p53 stabilizing agent CP 31398 dihydrochloride Chemical Structure
  23. GC32911 CTX1 CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system. CTX1 Chemical Structure
  24. GC43408 Deoxycholic Acid (sodium salt hydrate)

    DCA, Sodium Deoxycholate

     Deoxycholic acid (cholanoic acid) sodium hydrate，a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5. Deoxycholic Acid (sodium salt hydrate) Chemical Structure
  25. GC47187 Deoxycholic Acid-d4

    Cholanoic acid-d4, DCA-d4

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Deoxycholic Acid-d4 Chemical Structure
  26. GC33384 DPBQ DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. DPBQ Chemical Structure
  27. GC15258 GN25 p53-Snail binding Inhibitor GN25 Chemical Structure
  28. GC10650 HLI 373 HLI 373 Chemical Structure
  29. GC61608 HLI373 dihydrochloride HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride Chemical Structure
  30. GC14755 Inauhzin

    INZ

     SIRT1 inhibitor Inauhzin Chemical Structure
  31. GC12117 JNJ-26854165 (Serdemetan)

    Serdemetan

     An antagonist of MDM2 action JNJ-26854165 (Serdemetan) Chemical Structure
  32. GC32919 Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride)

    4-Isothioureidobutyronitrile, NSC 525990

     Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells. Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) Chemical Structure
  33. GC62629 MB710 MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1?μM. MB710 shows anticancer activity in p53-Y220C cell lines. MB710 Chemical Structure
  34. GC62716 MD-222 MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects. MD-222 Chemical Structure
  35. GC38812 MD-224 MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent. MD-224 Chemical Structure
  36. GC62557 MDM2-IN-1 MDM2-IN-1 (Compound 30) is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration. MDM2-IN-1 Chemical Structure
  37. GC69444 MDM2-p53-IN-16

    MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM for dissociating the human MDM2-p532 complex. It can reactivate p53 and induce apoptosis and cell cycle arrest in glioblastoma multiforme (GBM) cells. MDM2-p53-IN-16 can be used for cancer research purposes.

     MDM2-p53-IN-16 Chemical Structure
  38. GC36605 MI-1061 MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. MI-1061 Chemical Structure
  39. GC62598 MI-1061 TFA MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. MI-1061 TFA Chemical Structure
  40. GC16296 MI-773 MDM2 inhibitor MI-773 Chemical Structure
  41. GC11547 MI-773 (SAR405838)

    SAR405838

     MI-773 (SAR405838) (MI-77301), an analog of MI-773, is a highly potent and selective MDM2-p53 interaction inhibitor. MI-773 (SAR405838) binds to MDM2 with a Ki of 0.88 nM. MI-773 (SAR405838) induces apoptosis and has potent antitumor activity. MI-773 (SAR405838) Chemical Structure
  42. GC32881 Milademetan (DS-3032)

    DS-3032

     Milademetan (DS-3032) (DS-3032) is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) (DS-3032) induces G1 cell cycle arrest, senescence and apoptosis. Milademetan (DS-3032) Chemical Structure
  43. GC62621 Milademetan tosylate hydrate

    DS-3032b; DS-3032 tosylate hydrate

     Milademetan (DS-3032) tosylate hydrate is a specific and orally active MDM2 inhibitor for the research of acute myeloid leukemia (AML) or solid tumors. Milademetan (DS-3032) tosylate hydrate induces G1 cell cycle arrest, senescence and apoptosis. Milademetan tosylate hydrate Chemical Structure
  44. GC12893 MIRA-1

    NSC 19630

     A mutant p53 reactivator MIRA-1 Chemical Structure
  45. GC62322 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM. MS7972 Chemical Structure
  46. GC68371 Mutant p53 modulator-1 Mutant p53 modulator-1 Chemical Structure
  47. GC19257 MX69 MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment. MX69 Chemical Structure
  48. GC15621 NSC 146109 hydrochloride

    XI-011

     An activator of p53 NSC 146109 hydrochloride Chemical Structure
  49. GC15404 NSC 319726

    ZMC1

     A p53 reactivator NSC 319726 Chemical Structure
  50. GC16151 NSC348884 nucleophosmin inhibitor NSC348884 Chemical Structure
  51. GC16179 NSC59984

    Restores the p53 signaling pathway

     NSC59984 Chemical Structure
  52. GC16051 Nutlin-3

    Nutlin 3b

     A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3 Nutlin-3 Chemical Structure
  53. GC10470 Nutlin-3a chiral

    Nutlin 3a

     Nutlin-3a chiral, an active isomer of Nutlin-3, is a murine double microbody 2 (MDM2) antagonist with IC50 value of 0.09μM . Nutlin-3a chiral Chemical Structure
  54. GC12508 Nutlin-3b

    Nutlin 3b

     MDM2/p53 inhibitor Nutlin-3b Chemical Structure
  55. GC12647 NVP-CGM097

    CGM097

     potent and selective MDM2 inhibitor NVP-CGM097 Chemical Structure
  56. GC36785 NVP-CGM097 sulfate

    CGM097 sulfate

     NVP-CGM097 sulfate is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2. NVP-CGM097 sulfate Chemical Structure
  57. GC19268 NVP-HDM201

    NVP-HDM201; HDM201

     NVP-HDM201 (NVP-HDM201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. NVP-HDM201 Chemical Structure
  58. GC48652 Olomoucine II A CDK inhibitor Olomoucine II Chemical Structure
  59. GC11711 ONC201

    TIC10

     ONC201 (ONC-201) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. ONC201 can cross the blood-brain barrier. ONC201 Chemical Structure
  60. GC15613 p-nitro-Cyclic Pifithrin-α

    Cyclic pifithrin-α-p-nitro,p-nitro-Cyclic PFT-α

     p-nitro-Cyclic Pifithrin-α (PFN-α) is cell-permeable and active-form p53 inhibitor. p-nitro-Cyclic Pifithrin-α Chemical Structure
  61. GC15812 p-nitro-Pifithrin-α

    p-nitro-PFT-α

     p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α Chemical Structure
  62. GC67765 p53 Activator 5 p53 Activator 5 Chemical Structure
  63. GC69648 p53 Activator 7

    p53 Activator 7 is a p53 mutant Y220C (MDM-2/p53) activator with an EC50 of 104 nM. It can bind to p53 mutants and restore their ability to bind DNA (WO2022213975A1; Example B-1).

     p53 Activator 7 Chemical Structure
  64. GC36835 p53 and MDM2 proteins-interaction-inhibitor chiral p53 and MDM2 proteins-interaction-inhibitor chiral (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins. p53 and MDM2 proteins-interaction-inhibitor chiral Chemical Structure
  65. GC36836 p53 and MDM2 proteins-interaction-inhibitor dihydrochloride p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins. p53 and MDM2 proteins-interaction-inhibitor dihydrochloride Chemical Structure
  66. GC36837 p53 and MDM2 proteins-interaction-inhibitor racemic p53 and MDM2 proteins-interaction-inhibitor racemic (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins. p53 and MDM2 proteins-interaction-inhibitor racemic Chemical Structure
  67. GP10036 p53 tumor suppressor fragment

    H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH

    Regulates cell cycle

     p53 tumor suppressor fragment Chemical Structure
  68. GC65961 P53R3 P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research. P53R3 Chemical Structure
  69. GC45758 Paclitaxel octadecanedioate

    1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18

     A prodrug form of paclitaxel Paclitaxel octadecanedioate Chemical Structure
  70. GC47853 Paclitaxel-d5 An internal standard for the quantification of paclitaxel Paclitaxel-d5 Chemical Structure
  71. GC12658 PhiKan 083 PhiKan 083 Chemical Structure
  72. GC36896 PhiKan 083 hydrochloride PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells. PhiKan 083 hydrochloride Chemical Structure
  73. GC10538 Pifithrin-α (PFTα)

    PFTα

     Pifithrin-α(PFT-α) is a p53 inhibitor.Pifithrin-α widely used in neuroscience to block neuronal apoptotic cell death.Pifithrin-α is also a potent stimulant of aryl hydrocarbon receptor (AhR). Pifithrin-α (PFTα) Chemical Structure
  74. GC17262 Pifithrin-β

    PFTμ, 2Phenylethynesulfonamide

     potent p53 inhibitor Pifithrin-β Chemical Structure
  75. GC10282 Piperlongumine

    Piplartine

     Piperlongumine is a natural alkaloid compound extracted from Piper longum L., which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities. Piperlongumine Chemical Structure
  76. GC32946 PK11007 PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels. PK11007 Chemical Structure
  77. GC44652 PK7242 (maleate) The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. PK7242 (maleate) Chemical Structure
  78. GC64768 PK9327 PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations. PK9327 Chemical Structure
  79. GC10315 Plumbagin

    NSC 236613, NSC 688284

     A natural naphthoquinone Plumbagin Chemical Structure
  80. GC12086 PRIMA-1

    NSC-281668

     A re-activator of the apoptotic function of mutant p53 proteins PRIMA-1 Chemical Structure
  81. GC37010 PROTAC MDM2 Degrader-1 PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. PROTAC MDM2 Degrader-1 Chemical Structure
  82. GC37011 PROTAC MDM2 Degrader-2 PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. PROTAC MDM2 Degrader-2 Chemical Structure
  83. GC37012 PROTAC MDM2 Degrader-3 PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. PROTAC MDM2 Degrader-3 Chemical Structure
  84. GC37013 PROTAC MDM2 Degrader-4 PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. PROTAC MDM2 Degrader-4 Chemical Structure
  85. GC15946 ReACp53 inhibit p53 amyloid formation ReACp53 Chemical Structure
  86. GC10589 RETRA hydrochloride Antitumor agent RETRA hydrochloride Chemical Structure
  87. GC13019 RG7112

    RO5045337

     An inhibitor of the MDM2-p53 interaction RG7112 Chemical Structure
  88. GC11594 RG7388

    RG 7388; RG-7388; ldasanutlin; Ro 5503781

     An inhibitor of the MDM2-p53 interaction RG7388 Chemical Structure
  89. GC12793 RITA (NSC 652287)

    2,5bis(5hydroxymethyl2thienyl) Furan, NSC 652287, Reactivation of p53 and Induction of Tumor Cell Apoptosis

     An inhibitor of the p53-HDM-2 interaction RITA (NSC 652287) Chemical Structure
  90. GC37549 RO-5963 RO-5963 is a dual p53-MDM2 and p53-MDMX inhibitor with IC50s of ~17 nM and ~24 nM, respectively. RO-5963 Chemical Structure
  91. GC19312 RO8994 RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). RO8994 Chemical Structure
  92. GC18624 Roslin-2

    Benzylhexamethylenetetramine bromide

     Roslin-2 (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin-2 binds FAK, disrupts the binding of FAK and p53. Roslin-2 Chemical Structure
  93. GC13590 SJ 172550

    MDMX Inhibitor II

     A small molecule inhibitor of MDMX SJ 172550 Chemical Structure
  94. GC65284 SLMP53-1 SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels. SLMP53-1 Chemical Structure
  95. GC16371 Solasodine

    NSC 179187, NSC 178260, Purapuridine, Solancarpidine, Solasod-5-en-3β-ol, (-)-Solasodine

     An alkaloid with diverse biological activities Solasodine Chemical Structure
  96. GC69968 Sulanemadlin

    ALRN-6924; MP-4897

    Sulanemadlin (ALRN-6924) is a potent p53-based peptide macrocycle. Sulanemadlin is an inhibitor of protein-protein interactions between p53-MDM2, p53-MDMX, or p53 and MDM2 and MDMX. Sulanemadlin can be used for cancer research.

     Sulanemadlin Chemical Structure
  97. GC14165 Tenovin-1 A small molecule activator of p53 Tenovin-1 Chemical Structure
  98. GC12337 Tenovin-3

    Tenovin 3;Tenovin3

     p53 activator Tenovin-3 Chemical Structure
  99. GC16436 Tenovin-6 SIRT inhibitor and p53 activator Tenovin-6 Chemical Structure
  100. GC37761 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride, an analog of Tenovin-1, is an activator of p53 transcriptional activity. Tenovin-6 Hydrochloride inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 Hydrochloride also inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 Hydrochloride Chemical Structure
  101. GC61352 Triglycidyl isocyanurate Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate Chemical Structure

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