BRACO 19 trihydrochloride |
Catalog No.GC50140 |
Telomerase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1177798-88-7
Sample solution is provided at 25 µL, 10mM.
Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.
Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154 PMID:11961134 |Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489 PMID:15735037
Average Rating: 5
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