Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> Cell Cycle/Checkpoint >> ATM/ATR

ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

Products for  ATM/ATR

  1. Cat.No. Product Name Information
  2. GC34999 (S)-Ceralasertib

    (S)-AZD6738

     (S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM.(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition. (S)-Ceralasertib Chemical Structure
  3. GC65327 ATM Inhibitor-5

    M4076; ATM Inhibitor-5

     ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1). ATM Inhibitor-5 Chemical Structure
  4. GC65514 ATR inhibitor 1

    M1774; ATR inhibitor 1

     ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 ?Μ. ATR inhibitor 1 Chemical Structure
  5. GC74316 ATR kinase substrate peptide ATR kinase substrate peptide (compound 45) is a potent and selective inhibitor of ATR (Ataxia Telangiectasia and Rad3 related) protein kinase (Ki=6 nM). ATR kinase substrate peptide Chemical Structure
  6. GC68707 ATR-IN-4

    ATR-IN-4 is an effective ATR inhibitor. ATR-IN-4 inhibits the growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460, with IC50 values of 130.9 nM and 41.33 nM, respectively (excerpted from patent CN112142744A, compound 13).

     ATR-IN-4 Chemical Structure
  7. GC19047 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 uM for ATM in cell. AZ32 Chemical Structure
  8. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648 Chemical Structure
  9. GC11593 AZD0156 ATM kinase inhibitor AZD0156 Chemical Structure
  10. GC19468 AZD1390

    AZD1390 is a potent and selective ATM inhibitor

     AZD1390 Chemical Structure
  11. GC16941 AZD6738

    Ceralasertib

     AZD6738 (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM. AZD6738 Chemical Structure
  12. GC33420 BAY-1895344

    Elimusertib

     BAY-1895344 (BAY-1895344) is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. BAY-1895344 has anti-tumor activity. BAY-1895344 can be used for the research of solid tumors and lymphomas. BAY-1895344 Chemical Structure
  13. GC34374 BAY-1895344 hydrochloride An ATR inhibitor BAY-1895344 hydrochloride Chemical Structure
  14. GC14526 CGK733

    ATM/ATR Kinase Inhibitor

     ATM/ATR inhibitor,potent and selective CGK733 Chemical Structure
  15. GC16489 CP-466722 ATM inhibitor,potent and reversible CP-466722 Chemical Structure
  16. GC25372 Elimusertib (BAY-1895344) hydrochloride

    BAY-1895344 HCl

     Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. Elimusertib (BAY-1895344) hydrochloride Chemical Structure
  17. GC69053 Elimusertib-d3

    BAY 1895344-d3

    Elimusertib-d3 (BAY 1895344-d3) is the deuterated form of Elimusertib-d3 (BAY 1895344). Elimusertib is an effective, orally available, selective ATR inhibitor with anti-tumor activity.

     Elimusertib-d3 Chemical Structure
  18. GC10196 ETP-46464

    ATM Inhibitor III, ATR Inhibitor III

     ATR inhibitor,potent and selective ETP-46464 Chemical Structure
  19. GC33404 KU 59403 KU 59403 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively. KU 59403 Chemical Structure
  20. GC12054 KU-60019

    KU60019;KU 60019

     ATM kinase inhibitor,potent and selective KU-60019 Chemical Structure
  21. GC13491 Mirin Mirin is an inhibitor of Mre11-Rad50-Nbs1 (MRN) complex (IC50=12μM), which can inhibit the activity of MRE11-related exonuclease, and can inhibit the activation of MRN-dependent ATM. It is commonly used in the study of cancers related to DNA repair mechanisms. Mirin Chemical Structure
  22. GC64278 RP-3500

    RP-3500; ATR inhibitor 4

     RP-3500 (ATR inhibitor 4) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. RP-3500 shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. RP-3500 has potent antitumor activity. RP-3500 Chemical Structure
  23. GC64539 SKLB-197 SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo. SKLB-197 Chemical Structure
  24. GC10293 VE-821

    ATR Inhibitor IV

    ATR kinase inhibitor

     VE-821 Chemical Structure
  25. GC15337 VE-822 ATR inhibitor VE-822 Chemical Structure

24 Item(s)

per page

Set Descending Direction