D-(+)-Glucose-13C6 |
Catalog No.GC43367 |
D-(+)-Glucose-13C6 is the stable isotope labeled counterpart of D-(+)-Glucose and is mainly used as an internal standard for the quantification of D-(+)-Glucose by GC- or LC-MS measurement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 110187-42-3
Sample solution is provided at 25 µL, 10mM.
D-(+)-Glucose-13C6 is the stable isotope labeled counterpart of D-(+)-Glucose and is mainly used as an internal standard for the quantification of D-(+)-Glucose by GC- or LC-MS measurement [1]. D-(+)-Glucose is a monosaccharide that exists in nature and is used as an energy source by organisms. It is the common enantiomer of L-(-)-Glucose [2]. D-(+)-Glucose-13C6 can be used as a metabolic tracer to track glucose-related metabolic components in animals. For example, when added to the diet of fruit flies, changes in the concentrations of 15 amino acids can be detected [3]. D-(+)-Glucose-13C6 can be added to cell cultures to monitor fluctuations in cellular metabolite levels [4, 5].
References:
[1] Zhang H, Stevens R D, Young S P, et al. A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6] glucose as a tracer[J]. Clinical chemistry, 2009, 55(3): 527-532.
[2] Toxvaerd S. The role of carbohydrates at the origin of homochirality in biosystems[J]. Origins of Life and Evolution of Biospheres, 2013, 43: 391-409.
[3] Al-Khshemawee H, Agarwal M, Du B, et al. Efficacy of D-glucose-13C6 as a label for amino acid identification and quantification in Mediterranean fruit flies (Diptera: Tephritidae)[J]. Journal of Entomological Science, 2020, 55(1): 117-125.
[4] Mehrotra P, Saquib N, Rao K V S. 13C Kinetic Labeling and Extraction of Metabolites from Adherent Mammalian Cells[J]. Bio-protocol, 2015, 5(8): e1447-e1447.
[5] Luger A L, Lorenz N I, Urban H, et al. Activation of epidermal growth factor receptor sensitizes glioblastoma cells to hypoxia-induced cell death[J]. Cancers, 2020, 12(8): 2144.
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