Endocrinology and Hormones
Endocrinology and Hormones
The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more
Targets for Endocrinology and Hormones
- 5-alpha Reductase(8)
- Smoothened Receptors(3)
- Androgen Receptor(141)
- Aromatase(12)
- CRTH2(2)
- Estrogen/progestogen Receptor(163)
- GnRH(26)
- Opioid Receptor(176)
- RAAS(7)
- Thyroid hormone Receptor(62)
- TRH(1)
- ROR/RAR/RXR(92)
- FXR & LXR(82)
- Glucocorticoids & Mineralocorticoids(66)
- GPR(1)
- Androgen/Estrogen Receptor Modulators(1)
Products for Endocrinology and Hormones
- Cat.No. Product Name Information
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GC11282
β-Estradiol
β-Estradiol, Estradiol, 17β-Oestradiol, E2
Sex hormone
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GC49838
α-Cortolone
20α-Cortolone, NSC 59872
A metabolite of cortisol -
GC48292
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. -
GC60391
β-Casomorphin, bovine TFA
β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA
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GC61484
β-Casomorphin, human TFA
Human β-casomorphin 7 TFA
- GC45236 β-Endorphin (rat) β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.
- GC52494 β-Endorphin (rat) (trifluoroacetate salt) An opioid neuropeptide
- GC38005 β-Endorphin, equine β-Endorphin, equine is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors.
- GC38030 β-Endorphin, equine (TFA)
- GC72132 β-Endorphin, equine TFA β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors.
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GC45238
δ14-Triamcinolone acetonide
14,15-dehydro Triamcinolone acetonide, Triamcinolone acetonide Impurity B
δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. -
GC45239
δ4-Abiraterone
CB 7627, D4A
δ4-Abiraterone is a major metabolite of abiraterone. δ4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor. -
GC15975
α-Estradiol
Alfatradiol, α-Estradiol, 17-epi Estradiol, NSC 20293, 17α-Oestradiol
α-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia. - GC33736 β-Casomorphin, bovine (β-Casomorphin-7 (bovine)) β-Casomorphin, bovine (β-Casomorphin-7 (bovine)) (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
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GC33784
β-Casomorphin, human (Human β-casomorphin 7)
Human β-casomorphin 7
is an opioid peptide, acts as an agonist of opioid receptor. - GC31117 β-Endorphin, human β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.
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GC15938
β-Funaltrexamine hydrochloride
μ opioid receptor antagonist
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GC45713
(±)-α-Tocopherol Acetate
all-rac-α-Tocopherol Acetate, DL-α-Tocopherol Acetate, DL-Vitamin E acetate
(±)-α-Tocopherol Acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. -
GC41671
(±)-Equol 4'-sulfate (sodium salt)
R,S-Equol 4'-Sulfate
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
- GC50708 (±)-ML 209 An RORγt antagonist
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GC64007
(±)-U-50488 hydrate hydrochloride
(±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride
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GC15885
(±)-U-50488 hydrochloride
(±)-Trans-(1R,2R)-U-50488 hydrochloride
κ-opioid receptor agonist, selective
- GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1.
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GC12688
(+)-U-50488 hydrochloride
(+)-Trans-(1R,2R)-U-50488 hydrochloride
Selective κ-opioid agonist - GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
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GC15944
(-)-U-50488 hydrochloride
(-)-Trans-(1S,2S)-U-50488 hydrochloride
κ-opioid receptor agonist, selective -
GC70081
(1R,2R)-U-50488 hydrochloride
(1R,2R)-U-50488 hydrochloride is the absolute configuration of (±)-U-50488 hydrochloride. (±)-U-50488 hydrochloride is a κ opioid receptor agonist.
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GC34965
(20S)-Protopanaxatriol
20(S)-APPT, 20(S)-PPT
An active ginsenoside metabolite - GA20156 (D-Ser(tBu)⁶,Azagly¹⁰)-LHRH (free base)
- GA20164 (D-Trp¹²,Tyr³⁴)-pTH (7-34) amide (bovine) (D-Trp¹²,Tyr³⁴)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane.
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GC15373
(E)-2-Decenoic acid
trans-2-Decylenic Acid
An unsaturated fatty acid found in royal jelly - GC46336 (E)-Guggulsterone A farnesoid X receptor antagonist
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GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen -
GC40833
(E/Z)-Endoxifen
(E/Z)-N-desmethyl-4-hydroxy Tamoxifen
(E/Z)-Endoxifen is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. - GC61491 (R)-Bicalutamide (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide. (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.
- GC13373 (R)-DPN estrogen receptor (ER) β agonist
- GC30710 (R)-UT-155 (R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer.
- GC18003 (R,R)-THC ERα receptor agonist
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GC52185
(R,S)-Anatabine-d4
(±)-Anatabine-d4
- GC63292 (rac)-PF-998425 (Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist.
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GC69798
(Rac)-SNC80
(Rac)-NIH 10815
(Rac)-SNC80 is the racemic form of SNC80. SNC80 (NIH 10815) is an effective and highly selective non-peptide delta-opioid receptor agonist with a Ki of 1.78 nM and IC50 of 2.73 nM. SNC80 has anti-nociceptive, anti-hyperalgesic, and antidepressant-like effects, and can be used in research on various types of headaches.
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GC49520
(S)-Equol
4',7Dihydroxyisoflavan, (-)Equol, 4',7Isoflavandiol
An estrogen receptor β agonist
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GC16372
(Z)-4-Hydroxytamoxifen
ICI 79280, trans-4-hydroxy Tamoxifen
(Z)-4-Hydroxytamoxifen is a metabolite of Tamoxifen. (Z)-4-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. (Z)-4-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells. - GC62761 1α-Hydroxy-3-epi-vitamin D3 1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion.
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GC48787
11β-Hydroxyetiocholanolone
NSC 53897
A metabolite of hydrocortisone -
GC48710
11-Dehydrocorticosterone
11-DHC, DHCS, Kendall's Compound A, NSC 9702
An endogenous mineralocorticoid -
GC49161
16α-hydroxy Dehydroepiandrosterone
16α-hydroxy DHEA
A metabolite of dehydroepiandrosterone -
GC41950
16α-hydroxy Estrone
16α-hydroxy E1, 16αOHE1
The naturally-occurring estrogens are estrone, estradiol, and estriol. - GC46456 16α-Hydroxyetiocholanolone A metabolite of 16α-DHEA and androstenedione
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GC40454
16(S)-HETE
16(S)-Hydroxyeicosatetraenoic Acid
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. -
GC49068
16-Epiestriol
16-epi Estriol, 16-EpiE3, 16β-hydroxy-17α-Estradiol, NSC 26646
A metabolite of estrone -
GC49848
16-Ketoestradiol
16-keto E2, NSC 51169, 16-Oxoestradiol
An active metabolite of estrone -
GC17557
17 alpha-propionate
CB-03-01
A peripherally selective androgen receptor antagonist -
GC41321
17α,20β-Dihydroxy-4-pregnen-3-one
17α,20β-DHP,17α,20β-dihydroxy Progesterone
An endogenous, maturation-inducing steroid -
GC46470
17β-Estradiol-d2
2,4-Dideuteriostradiol, E2-d2, Estradiol-d2, β-Estradiol-d2, 17β-Oestradiol-d2
17β-Estradiol-d2 (β-17β-Estradiol-d2) is the deuterium labeled Estradiol. - GC41300 17β-hydroxy Exemestane 17β-hydroxy Exemestane is the primary active metabolite of exemestane.
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GC48819
17-Epiestriol
16α-hydroxy-17α-Estradiol, 16α,17α-Estriol, 17α-Estriol, 17-epi-Estriol, NSC 84051
A metabolite of estrone -
GC17475
17-Hydroxyprogesterone
NSC 15468, 17-OHP, 17-hydroxy Progesterone
An endogenous progestogen and chemical intermediate -
GC18635
18-hydroxy-11-deoxy Corticosterone
18-Hydroxydeoxycorticosterone, 18-OH-DOC
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. - GC35069 2,2,5,7,8-Pentamethyl-6-Chromanol 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
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GC49671
2,3-Oxidosqualene
(3R,S)-Oxidosqualene, Squalene 2,3-oxide
An intermediate in the biosynthesis of sterols -
GC66679
2,6-Dimethyl-L-tyrosine
Dmt
2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides. -
GC49609
2-bromo 17β-Estradiol
2-bromo E2, 2-bromo β-Estradiol, 2-bromo Estradiol, NSC 105460, 2-bromo 17β-Oestradiol
A synthetic steroid and inhibitor of estrogen 2-hydroxylase -
GC49172
2-hydroxy Estrone
Catecholestrone, 2-hydroxy E1, 2-OHE1
An active metabolite of estrone -
GC17160
2-hydroxy Flutamide
Hydroxyniphtholide,SCH 16423
2-hydroxy Flutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). 2-hydroxy Flutamide can be used for the research of prostate cancer. -
GC48910
2-Hydroxyanthraquinone
2-hydroxy-9,10-Anthraquinone, 2-hATQ, β-Hydroxyanthraquinone, NSC 2595
An anthraquinone with antibacterial and estrogenic activities -
GC40960
20α-dihydro Prednisolone
20α-DHP, 20α-dihydro-PRED, 20(R)-hydroxy Prednisolone, 20α-hydroxy Prednisolone
20α-dihydro Prednisolone is a metabolite of prednisolone. -
GC46526
21-Deoxycortisol
21-Dehydrohydrocortisone
A corticosteroid metabolite of 17-hydroxyprogesterone -
GC49611
21-Deoxycortisol-d8
21-Dehydrohydrocortisone-d8
An internal standard for the quantification of 21-deoxycortisol -
GC52083
21-Deoxycortisone
21-Desoxycortisone, NSC 38722
A corticosteroid metabolite of 11-keto progesterone - GC40968 21-hydroxy Eplerenone 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone.
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GC14972
22(R)-hydroxy Cholesterol
Narthesterol
endogenous agonist for LXRs -
GC18270
22(S)-hydroxy Cholesterol
22β-hydroxy Cholesterol
A synthetic oxysterol and LXR modulator -
GC17827
24(R)-hydroxy Cholesterol
24-Epicerebrosterol
LXRα and LXRβ nuclear receptors activator
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GC40571
24(S),25-epoxy Cholesterol
24(S)-24,25-EC
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.
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GC18076
24(S)-hydroxy Cholesterol
Cerebrosterol
LXRα and LXRβ nuclear receptors activator
- GC33673 24-Hydroxycholesterol 24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
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GC13431
24α-methyl Cholesterol
Campesterol,NSC 224330
24α-methyl Cholesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects. -
GC13887
25(R)-27-hydroxy Cholesterol
(25R)-26-hydroxy cholesterol
25(R)-27-hydroxy Cholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor. -
GC11700
25(S)-27-hydroxy Cholesterol
(25S)-26-hydroxy cholesterol
liver x receptors (LXRα and LXRβ) activator -
GC10384
3,3',5'-Triiodo-L-thyronine
Reverse T3,rT3,3,3’,5’-T3
3,3',5'-Triiodo-L-thyronine is a thyroid hormone generated by deiodination of the prohormone thyroxine. -
GC48395
3,3',5-Triiodo-L-thyronine (sodium salt hydrate)
Liothyronine, T3, L3,3',5Triiodothyronine
3,3',5-Triiodo-L-thyronine (sodium salt hydrate) is an active form of thyroid hormone. -
GC12791
3,3'-Diindolylmethane
DIM
A phytochemical with antiradiation and chemopreventative effects -
GC49427
3,5-Diiodo-L-thyronine
3,5-Diiodothyronine, NSC 90469, 3,5-T2
3,5-Diiodo-L-thyronine is an endogenous metabolite. -
GC18205
3,5-Diiodothyroacetic Acid
Diac, NSC 90463, T2A, TA2
3,5-Diiodothyroacetic acid (diac) is the acetic acid variant of thyroxine. -
GC18696
3,5-Diiodothyropropionic Acid
DITPA
3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors). -
GC52129
3-Amino-5-hydroxybenzoic Acid
AHBA
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GC49180
3-epi-25-hydroxy Vitamin D3
3-epi-25(OH)D3, 3-epi-25-hydroxy Cholecalciferol
The C-3 epimer of 25-hydroxy vitamin D3 -
GC18462
3-Formylsalicylic Acid
NSC 55753
3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone. -
GC42294
3-Iodothyronamine (hydrochloride)
T1AM
3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine. -
GC48824
4-hydroxy Estrone
4-hydroxy E1, 4-OHE1
A metabolite of estrone -
GC17803
4-Hydroxytamoxifen
Afimoxifene, 4-OHT
4-Hydroxytamoxifen (Afimoxifene) is a racemic compound of (Z)-4-Hydroxytamoxifen and (E)-4-Hydroxytamoxifen isomers. 4-Hydroxytamoxifen is an estrogen receptor modulator. -
GC49562
4-methoxy Estrone
4-MeOE1, 4-methoxy E1
An active metabolite of estrone -
GC11606
4-Methylbenzylidene camphor
Enzacamene|Eusolex 6300|4-MBC|Neo Heliopan MBC|Parsol 500|Uvinul MBC 95
ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities. -
GC42473
4-tert-Octylphenol diethoxylate
OP2EO
4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. -
GC52365
4-tert-Octylphenol monoethoxylate
NSC 5259, OP1EO
An alkylphenolethoxylate and a degradation product of non-ionic surfactants - GC13917 4’-hydroxy Tamoxifen metabolite of tamoxifen, an estrogen receptor modulator
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GC40053
5α,6α-epoxy Cholestanol
NSC 18176
An oxysterol and a metabolite of cholesterol produced by oxidation -
GC42569
5α-Androst-16-en-3-one
Androstenone
5α-Androst-16-en-3-one is a mammalian pheromone released as a volatile chemical cue in boar saliva to facilitate social and sexual interactions. -
GC49542
5α-Androstan-3β-ol
NSC 50887
A steroidal androgen