Sancycline (hydrochloride) (Synonyms: 6-Demethyl-6-deoxytetracycline, NSC 51812)

Sancycline is a semi-synthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively).1,2 Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml.3 In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

References
1. McCormick, J.R.D., Jensen, E.R., Miller, P.A., et al. The 6-deoxytetracyclines. Further studies on the relationship between structure and antibacterial activity in the tetracycline series. J. Am. Chem. Soc. 82(13), 3381-3386 (1960).
2. Wexler, H.M., Molitoris, E., and Finegold, S.M. In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria. Antimicrob. Agents Chemother. 38(10), 2513-2515 (1994).
3. Testa, R.T., Perterson, P.J., Jacobus, N.V., et al. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob. Agents Chemother. 37(11), 2270-2277 (1993).