GI 530159 |
| Catalog No.GC50547 |
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 69563-88-8
Sample solution is provided at 25 µL, 10mM.
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TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.
Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID:29150838
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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