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Home >> Signaling Pathways >> Immunology/Inflammation >> NF-κB

NF-κB

NF-κB is a family of conserved and ubiquitous transcription factors that involved in various biological processes including immunity, inflammation, cell growth, differentiation and apoptosis. It is associated with cancer, chronic inflammation and arthritis etc.

Products for  NF-κB

  1. Cat.No. Product Name Information
  2. GC40440 (±)8(9)-EET

    (±)8,9EpETrE

     (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET Chemical Structure
  3. GC40838 (±)8(9)-EET methyl ester

    (±)8,9EpETrE methyl ester

     (±)8(9)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450. (±)8(9)-EET methyl ester Chemical Structure
  4. GC46264 (±)8(9)-EET-d11

    (±)8,9-EET-d11, (±)8,9-EpETrE-d11

     A neuropeptide with diverse biological activities (±)8(9)-EET-d11 Chemical Structure
  5. GC45921 (±)8(9)-EET-d11 methyl ester

    (±)8,9-EpETrE-d11 methyl ester

     A neuropeptide with diverse biological activities (±)8(9)-EET-d11 methyl ester Chemical Structure
  6. GC40266 (+)-Praeruptorin A (+)-Praeruptorin A is a coumarin derivative originally isolated from P. (+)-Praeruptorin A Chemical Structure
  7. GC40264 (+)-Valencene

    NSC 148969

    (+)-Valencene is a sesquiterpene that has been found in C.

     (+)-Valencene Chemical Structure
  8. GC32705 (-)-DHMEQ (Dehydroxymethylepoxyquinomicin)

    Dehydroxymethylepoxyquinomicin

     (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ (Dehydroxymethylepoxyquinomicin) Chemical Structure
  9. GC61564 (E/Z)-IT-603 (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 Chemical Structure
  10. GC13030 (R)-(-)-Ibuprofen

    (-)-Ibuprofen

     Inhibitor of Cox-1 and Cox-2 (R)-(-)-Ibuprofen Chemical Structure
  11. GC69823 (R)-(-)-Ibuprofen-d3

    (R)-Ibuprofen-d3

    (R)-(-)-Ibuprofen-d3 is the deuterated form of (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, which has no effect on COX and can inhibit NF-κB activation. (R)-(-)-Ibuprofen has anti-inflammatory properties and can be used in pain relief research.

     (R)-(-)-Ibuprofen-d3 Chemical Structure
  12. GC18773 (Rac)-Benpyrine A racemate of Benpyrine, is a potent and orally active TNF-α inhibitor (Rac)-Benpyrine Chemical Structure
  13. GC39321 (Rac)-Myrislignan (Rac)-Myrislignan is the racemate of Myrislignan. (Rac)-Myrislignan Chemical Structure
  14. GC10821 11-keto-β-Boswellic Acid

    11-oxo-β-Boswellic acid,KBA

     11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  15. GC26213 13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile

    DIHYDROSANGUINARINE

    13,14-Dihydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine-14-carbonitrile Chemical Structure
  16. GC40763 14-deoxy-11,12-didehydro Andrographolide

    14-dehydro Andrographolide

     14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. 14-deoxy-11,12-didehydro Andrographolide Chemical Structure
  17. GC68044 2,4,6-Trihydroxybenzaldehyde 2,4,6-Trihydroxybenzaldehyde Chemical Structure
  18. GC39325 2,5-Dihydroxyacetophenone 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. 2,5-Dihydroxyacetophenone Chemical Structure
  19. GC60467 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone? 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure
  20. GC70284 3'-Sialyllactose 3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose Chemical Structure
  21. GC62033 3α-Hydroxy pravastatin sodium

    3α-Isopravastatin, R-416

     3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. 3α-Hydroxy pravastatin sodium Chemical Structure
  22. GC42406 4'-hydroxy Chalcone

    2-Benzal-4'-hydroxyacetophenone, 2-Benzylidene-4'-hydroxyacetophenone, p-Cinnamoylphenol, NSC 242264

     4'-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. 4'-hydroxy Chalcone Chemical Structure
  23. GC38663 4-Hydroxychalcone

    2-Benzal-4'-hydroxyacetophenone, 2-Benzylidene-4'-hydroxyacetophenone, p-Cinnamoylphenol, NSC 242264

     A chalcone metabolite with diverse biological activities 4-Hydroxychalcone Chemical Structure
  24. GC35143 4-O-Methyl honokiol

    NSC 293101, 4-Methoxyhonokiol

     A phenol with diverse biological activities 4-O-Methyl honokiol Chemical Structure
  25. GC73301 5-Aminosalicylic acid-d3

    Mesalamine-d3; 5-ASA-d3; Mesalazine-d3

     5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid-d3 Chemical Structure
  26. GC52413 5-Aminosalicylic Acid-d7

    5-ASA-d7, Mesalamine-d7, Mesalazine-d7

     An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  27. GC35185 7,4'-Dihydroxyflavone

    7,4'-DHF

     7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone Chemical Structure
  28. GC71920 7-O-Methylaloesinol 7-O-Methylaloesinol is a chromone derivative. 7-O-Methylaloesinol Chemical Structure
  29. GC35199 8-Deoxygartanin 8-Deoxygartanin, a prenylated xanthones from G. 8-Deoxygartanin Chemical Structure
  30. GN10212 8-O-Acetyl shanzhiside methyl ester 8-O-Acetyl shanzhiside methyl ester Chemical Structure
  31. GC15598 Ac2-26 inhibitor of leukocyte extravasation Ac2-26 Chemical Structure
  32. GC35224 Ac2-26 TFA Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 TFA Chemical Structure
  33. GN10536 Aconine Aconine Chemical Structure
  34. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol Chemical Structure
  35. GC71997 Alphitolic acid Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid Chemical Structure
  36. GC71003 ALPK1-IN-1 ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1-IN-1 Chemical Structure
  37. GC67968 ALPK1-IN-2 ALPK1-IN-2 Chemical Structure
  38. GC71384 ALPK1-IN-3 ALPK1-IN-3 is an inhibitor of ALPK1 extracted from patent WO2022063153A1 compound T007. ALPK1-IN-3 Chemical Structure
  39. GC39254 Anatabine dicitrate Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate Chemical Structure
  40. GN10718 Andrographolide Andrographolide Chemical Structure
  41. GC35340 Andropanolide Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andropanolide Chemical Structure
  42. GN10685 Anemarsaponin B Anemarsaponin B Chemical Structure
  43. GC71352 Anti-inflammatory agent 51 Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 Chemical Structure
  44. GN10579 Aristolochic Acid A

    Aristolochic Acid A, Aristolochic Acid I, NSC 11926, NSC 50413, Tardolyt

     Aristolochic Acid A Chemical Structure
  45. GC35394 Armepavine Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine Chemical Structure
  46. GC35401 Asatone Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways. Asatone Chemical Structure
  47. GC35412 Asperulosidic Acid Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid Chemical Structure
  48. GN10415 Astilbin

    Taxifolin 3-O-rhamnoside

     Astilbin Chemical Structure
  49. GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Avenanthramide-C methyl ester Chemical Structure
  50. GC39280 B022 B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM). B022 Chemical Structure
  51. GN10018 Baicalin

    Baicalein 7-glucuronide

     Baicalin is a flavonoid glycoside and an allosteric carnitine palmitoyltransferase 1 (CPT1) activator. Baicalin Chemical Structure
  52. GC45820 Balsalazide-d4 A neuropeptide with diverse biological activities Balsalazide-d4 Chemical Structure
  53. GC10345 Bay 11-7085

    NK-κB activation inhibitor

     Bay 11-7085 Chemical Structure
  54. GC13035 Bay 11-7821

    BAY 11-7082

     Bay 11-7821(BAY 11-7082) is an inhibitor of IκBα phosphorylation and NF-κB, selectively and irreversibly inhibits TNF-α-induced IκB-α phosphorylation (IC50 value is approximately 10μM), and reduces the expression of NF-κB and adhesion molecules. Bay 11-7821 inhibits ubiquitin-specific proteases USP7 and USP21 with IC50 values of 0.19 and 0.96μM, respectively . Bay 11-7821 Chemical Structure
  55. GC35494 Benzoyloxypaeoniflorin Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin Chemical Structure
  56. GN10443 Berbamine Berbamine Chemical Structure
  57. GN10358 Berbamine hydrochloride Berbamine hydrochloride Chemical Structure
  58. GC10480 Betulinic acid

    Lupatic Acid, NSC 113090

     Betulinic acid is a natural pentacyclic triterpenoid compound and an inhibitor of eukaryotic topoisomerase I with an IC50 value of 5 μM. Betulinic acid Chemical Structure
  59. GC42954 BMS 470539 (hydrochloride)

    BMS 470539 is an agonist of melanocortin receptor 1 (MC1R) with EC50 values of 16.8 and 11.6 nM for human and murine MC1R, respectively, in a cAMP accumulation assay.

     BMS 470539 (hydrochloride) Chemical Structure
  60. GC65010 Bortezomib-d8

    PS-341-d8; LDP-341-d8; NSC 681239-d8

     Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8 Chemical Structure
  61. GC40352 Cafestol Cafestol is a natural diterpene which is abundant in unfiltered coffee. Cafestol Chemical Structure
  62. GC10692 Caffeic Acid Phenethyl Ester

    CAPE, 2Phenylethyl Caffeate, βPhenylethyl Caffeate

     NF-κB activation inhibitor Caffeic Acid Phenethyl Ester Chemical Structure
  63. GC18069 Cardamonin

    Alpinetin chalcone, Cardamomin

     Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin Chemical Structure
  64. GC43165 CAY10512 The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. CAY10512 Chemical Structure
  65. GC41601 CAY10591

    SIRT1 Activator 3, Sirtuin 1 Activator 3

     CAY10591 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. CAY10591 Chemical Structure
  66. GC43190 CAY10682 (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 Chemical Structure
  67. GC15394 CBL0137 (hydrochloride)

    CBLC137,Curaxin 137

    curaxin that activates p53 and inhibits NF-κB

     CBL0137 (hydrochloride) Chemical Structure
  68. GC35629 CDDO-dhTFEA

    RTA dh404

     CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. CDDO-dhTFEA Chemical Structure
  69. GC52081 Chamazulene

    Dimethulene

    Chamazulene is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities.

     Chamazulene Chemical Structure
  70. GC31886 Chelidonic acid

    NSC 3979

     A pyran with diverse biological activities Chelidonic acid Chemical Structure
  71. GC12532 CHPG

    Chlorohydroxyphenylglycine, CHPG

     mGlu5 metabotropic glutamate receptor agonist CHPG Chemical Structure
  72. GC17963 CHPG Sodium salt mGlu5 agonist CHPG Sodium salt Chemical Structure
  73. GC17873 CID-2858522

    CID 2858522;CID2858522

     A selective inhibitor of NF-κB activation CID-2858522 Chemical Structure
  74. GC39701 Convallatoxin Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin Chemical Structure
  75. GN10409 cor-nuside

    Cornuside I

     cor-nuside Chemical Structure
  76. GC38031 CORM-3 CORM-3 Chemical Structure
  77. GC72888 CPS-11

    N-(Hydroxymethyl)thalidomide

     CPS-11 (N-(droxymetl)thalidomide) a Thalidomide analogue, is a potent anti-cancer agent. CPS-11 Chemical Structure
  78. GN10442 Curculigoside Curculigoside Chemical Structure
  79. GC30806 Cyclo(his-pro) (Cyclo(histidyl-proline))

    Cyclo(His-Pro), Cyclo(histidyl-proline), Histidylproline diketopiperazine, Histidylproline dioxopiperazine

     Cyclo(his-pro) (Cyclo(histidyl-proline)) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) (Cyclo(histidyl-proline)) Chemical Structure
  80. GC38761 Cyclo(his-pro) TFA

    Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA

     Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA Chemical Structure
  81. GN10178 Cyclohexanecarboxylicacid

    1-Caffeoylquinic Acid, 1-CQA

     Cyclohexanecarboxylicacid Chemical Structure
  82. GC33330 Cynaropicrin A sesquiterpene lactone Cynaropicrin Chemical Structure
  83. GC38182 Dauricine Dauricine Chemical Structure
  84. GC73740 DCZ5418 DCZ5418 is an inhibitor of TRIP13. DCZ5418 Chemical Structure
  85. GC38184 Dehydrodiisoeugenol Dehydrodiisoeugenol Chemical Structure
  86. GC38431 Dehydroevodiamine Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine Chemical Structure
  87. GC38101 Demethyleneberberine Demethyleneberberine (DMB), as a natural active component of medicinal plant Cortex phellodendri chinensis, has favorable bioactivity. Demethyleneberberine Chemical Structure
  88. GC68961 Demethyleneberberine chloride

    Demethyleneberberine chloride is a natural mitochondrial-targeted antioxidant. It alleviates colitis in mice and inhibits inflammatory responses by suppressing the NF-κB pathway and regulating Th cell balance. Demethyleneberberine chloride can also serve as an AMPK activator for research on non-alcoholic fatty liver disease (NAFLD).

     Demethyleneberberine chloride Chemical Structure
  89. GC34556 Dendrophenol Dendrophenol (Moscatilin) acts as a NF-κB inhibitor. Antineoplastic activity. Dendrophenol Chemical Structure
  90. GC60129 Deoxyelephantopin Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling. Deoxyelephantopin Chemical Structure
  91. GC33150 DHMEQ racemate (rel-DHMEQ)

    rel-DHMEQ

     DHMEQ racemate (rel-DHMEQ) is a NF-κB inhibitor. DHMEQ racemate (rel-DHMEQ) is less active than (-)-DHMEQ. DHMEQ racemate (rel-DHMEQ) Chemical Structure
  92. GN10056 Dihydroartemisinin

    DHQHS 2, Dihydroqinghaosu

     Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs) and is an effective drug widely used in the clinic to treat malaria. Dihydroartemisinin Chemical Structure
  93. GC52194 Dimethylamino Parthenolide

    DMAPT, LC-1

     Dimethylamino Parthenolide Chemical Structure
  94. GC43498 DL-α-Lipoic Acid

    Thioctic Acid

     DL-α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. DL-α-Lipoic Acid Chemical Structure
  95. GC34901 DMAPT

    Dimethylamino Parthenolide

     A water-soluble parthenolide analog DMAPT Chemical Structure
  96. GC31557 Edasalonexent (CAT-1004)

    CAT-1004

     Edasalonexent (CAT-1004) (CAT-1004) is an orally bioavailable NF-κB inhibitor. Edasalonexent (CAT-1004) Chemical Structure
  97. GC16044 Emodin

    Archin, Frangulic Acid, NSC 408120, NSC 622947, Schuttgelb

     Natural CK2 inhibitor and ER agonist Emodin Chemical Structure
  98. GC74157 EN450 EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 Chemical Structure
  99. GN10646 Engeletin

    Dihydrokaempferol 3-O-α-L-rhamnopyranoside, (+)-(2R,3R)-Dihydrokaempferol 3-O-α-L-rhamnoside, Dihydrokaempferol 3-rhamnoside

     Engeletin Chemical Structure
  100. GC43611 Enniatin B1 Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Enniatin B1 Chemical Structure
  101. GC18046 Erdosteine

    Erdostin

     mucolytic Erdosteine Chemical Structure

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