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Home >> Signaling Pathways >> Immunology/Inflammation >> STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

Targets for  STING

Products for  STING

  1. Cat.No. Product Name Information
  2. GC49912 13C20,15N10-Cyclic di-GMP (sodium salt)

    13C20,15N10-c-di-GMP, 13C20,15N10-Cyclic diguanylate, 13C20,15N10-3’,5’-Cyclic diguanylic Acid

     An internal standard for the quantification of cyclic di-GMP 13C20,15N10-Cyclic di-GMP (sodium salt) Chemical Structure
  3. GC42080 2'2'-cGAMP (sodium salt)

    Adenosine-Guanosine 2’,2’-cyclic monophosphate, cGAMP(2’-5’), 2’,2’-Cyclic GMP-AMP

     2'2'-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds. 2'2'-cGAMP (sodium salt) Chemical Structure
  4. GC42090 2'3'-cGAMP (sodium salt)

    Guanosine-Adenosine 2',3'-cyclic monophosphate, 2'-3'-Cyclic GMP-AMP

    2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.

     2'3'-cGAMP (sodium salt) Chemical Structure
  5. GC25014 3',3'-cGAMP

    3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP

     3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs. 3',3'-cGAMP Chemical Structure
  6. GC42245 3'3'-cGAMP (sodium salt)

    AdenosineGuanosine 3',3'-cyclic monophosphate, 3',3'-Cyclic GMP-AMP, c-GpAp

     3'3'-cGAMP is a second messenger produced in bacteria by specific dinucleotide cyclases. 3'3'-cGAMP (sodium salt) Chemical Structure
  7. GC48381 5'-pApA (sodium salt)

    c-di-AMP Control, Cyclic di-AMP Negative Control

     A linearized form of cyclic di-AMP 5'-pApA (sodium salt) Chemical Structure
  8. GC48375 5'-pGpG (sodium salt)

    c-di-GMP Control, Cyclic di-GMP Negative Control

     A linearized form of cyclic di-GMP 5'-pGpG (sodium salt) Chemical Structure
  9. GC49238 93-O17S A cationic lipidoid 93-O17S Chemical Structure
  10. GC31649 ADU-S100 (ML RR-S2 CDA)

    MIW815; ML RR-S2 CDA

     ADU-S100 (ML RR-S2 CDA) (MIW815), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity. ADU-S100 (ML RR-S2 CDA) Chemical Structure
  11. GC39161 ADU-S100 disodium salt

    MIW815 disodium salt; ML RR-S2 CDA disodium salt

     ADU-S100 disodium salt (MIW815 disodium salt) is an activator of stimulatory interferon gene (STING) protein with a Kd of 4.61±0.42μM[1]. ADU-S100 disodium salt Chemical Structure
  12. GC74005 AK59 AK59 is a STING degrader that works by leveraging HERC4, a hect domain E3 ligase. AK59 Chemical Structure
  13. GC71433 Anti-inflammatory agent 70 Anti-inflammatory agent 70 (N-Me-SP23) is a STING protein degrader and inhibits the STING signaling pathway. Anti-inflammatory agent 70 Chemical Structure
  14. GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Avenanthramide-C methyl ester Chemical Structure
  15. GC91659 BDW-OH BDW-OH is an active metabolite of the STING agonist and prodrug BDW568 . BDW-OH Chemical Structure
  16. GC91379 BDW568 BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. BDW568 Chemical Structure
  17. GC91947 BH400 BH400 is an agonist of peroxisome proliferator-activated receptor α (PPARα) and an inhibitor of stimulator of interferon genes (STING; IC50 = 8.1 ?M). BH400 Chemical Structure
  18. GC19069 BI605906 BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP. BI605906 Chemical Structure
  19. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM). BMS 345541 (trifluoroacetate salt) Chemical Structure
  20. GC90705 BSP-16

    A STING agonist

     BSP-16 Chemical Structure
  21. GC46983 C-170 C-170 (C-170) is a potent and covalent STING inhibitor. C-170 Chemical Structure
  22. GC46984 C-171 C-171 is an inhibitor of stimulator of interferon genes (STING). C-171 Chemical Structure
  23. GC33823 C-176 (STING inhibitor 1) C-176 (STING inhibitor 1) strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. C-176 (STING inhibitor 1) Chemical Structure
  24. GC38494 C-178 A STING inhibitor C-178 Chemical Structure
  25. GC40570 C-178 C-178 is a covalent inhibitor of STING. C-178 Chemical Structure
  26. GC13643 c-di-AMP

    C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF.

     c-di-AMP Chemical Structure
  27. GC62893 c-di-AMP diammonium

    Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

     c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium Chemical Structure
  28. GC64445 c-di-AMP disodium

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium Chemical Structure
  29. GC62198 c-di-AMP sodium

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     C-di-AMP is a STING agonist, which binds to the transmembrane protein STING, thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium Chemical Structure
  30. GC50687 c-Di-AMP sodium salt c-Di-AMP sodium salt Chemical Structure
  31. GC50292 c-Di-GMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling c-Di-GMP sodium salt Chemical Structure
  32. GC43176 CAY10575

    IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1

     CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM. CAY10575 Chemical Structure
  33. GC18782 CAY10657 The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules. CAY10657 Chemical Structure
  34. GC47054 CAY10748 A STING agonist CAY10748 Chemical Structure
  35. GC14727 CCCP

    Carbonyl cyanide m-chlorophenyl hydrazone, NSC 88124

     Carbonylcyanide-3-chlorophenylhydrazone (CCCP) is a protonophore, which causes uncoupling of proton gradient in the inner mitochondrial membrane, thus inhibiting the rate of ATP synthesis. CCCP Chemical Structure
  36. GC31696 cGAMP (Cyclic AMP-GMP)

    Cyclic GMP-AMP; 3',3'-cGAMP

     cGAMP (Cyclic AMP-GMP) (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP (Cyclic AMP-GMP) Chemical Structure
  37. GC63758 cGAMP diammonium

    Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium

     cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium Chemical Structure
  38. GC34329 ChX710 ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3. ChX710 Chemical Structure
  39. GC31875 CL656 (c-[2'FdAMP(S)-2'FdIMP(S)])

    c-[2’FdAMP(S)-2’FdIMP(S)]

     CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) is an activator of stimulator of interferon genes (STING). CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) Chemical Structure
  40. GC45413 Cridanimod (sodium salt)

    10-Carboxymethyl-9-Acridanone

       Cridanimod (sodium salt) Chemical Structure
  41. GC47128 CU-32 A cGAS inhibitor CU-32 Chemical Structure
  42. GC47129 CU-76 A cGAS inhibitor CU-76 Chemical Structure
  43. GC43339 Cyclic di-AMP (sodium salt)

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Cyclic di-AMP (sodium salt) Chemical Structure
  44. GC15048 Cyclic di-GMP

    second messenger

     Cyclic di-GMP Chemical Structure
  45. GC19526 Cyclic di-GMP disodium

    c-di-GMP, Cyclic diguanylate, 3',5'-Cyclic diguanylic acid

     Cyclic di-GMP (sodium salt) is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic di-GMP (sodium salt) has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic di-GMP (sodium salt) can be used in cancer research. Cyclic di-GMP disodium Chemical Structure
  46. GC43340 Cyclic di-IMP (sodium salt)

    c-di-IMP, Cyclic di-inosine monophosphate

     Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP. Cyclic di-IMP (sodium salt) Chemical Structure
  47. GC48397 Cyclic di-UMP (sodium salt)

    c-di-UMP, c-UpUp, Cyclic di-Uridine monophosphate, 3’3’-Cyclic UMP-UMP

     A pyrimidine-containing CDN Cyclic di-UMP (sodium salt) Chemical Structure
  48. GC62917 Cyclic-di-GMP diammonium

    c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium

     Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research. Cyclic-di-GMP diammonium Chemical Structure
  49. GC62372 Cyclic-di-GMP sodium

    c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium

     Cyclic-di-GMP sodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP sodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP sodium can be used in cancer research. Cyclic-di-GMP sodium Chemical Structure
  50. GC35853 diABZI STING agonist-1 diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. diABZI STING agonist-1 Chemical Structure
  51. GC35854 diABZI STING agonist-1 Tautomerism diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. diABZI STING agonist-1 Tautomerism Chemical Structure
  52. GC35855 diABZI STING agonist-1 trihydrochloride

    Diamidobenzimidazole STING Agonist-1, STING Agonist (Compound 3), STING Agonist diABZI

     diABZI STING agonist-1 trihydrochloride, as a STING agonist, is internalized into the cytoplasm through unknown receptor and induce the activation and dimerization of STING followed by TBK1/IRF3 phosporylation leading to type I IFN response. diABZI STING agonist-1 trihydrochloride Chemical Structure
  53. GC63473 diABZI-C2-NH2 diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist. diABZI-C2-NH2 Chemical Structure
  54. GC16280 DMXAA (Vadimezan)

    AS-1404, 5,6-MeXAA, NSC-640488, Vadimezan

    DMXAA (Vadimezan) is a selective DT-diaphorase inhibitor with a Ki value of 20μM and an IC50 value of 62.5μM.

     DMXAA (Vadimezan) Chemical Structure
  55. GC62608 E7766 diammonium salt E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities. E7766 diammonium salt Chemical Structure
  56. GC62609 E7766 disodium E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities. E7766 disodium Chemical Structure
  57. GC73576 Enpp-1-IN-19 Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP drolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 Chemical Structure
  58. GC74032 Enpp-1-IN-20 Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC50 of 0.09 nM. Enpp-1-IN-20 Chemical Structure
  59. GC52334 ENPP1 Inhibitor 4e

    cGAMP-compound 4e

     An ENPP1 inhibitor ENPP1 Inhibitor 4e Chemical Structure
  60. GC64257 Gelsevirine Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. Gelsevirine Chemical Structure
  61. GC34610 H-151 H-151 is a low MW antagonist of STING, which blocks the activation-induced palmitoylation of STING, and exhibits significant inhibitory effects on STING signalling H-151 can be used in the study of autoinflammatory diseases. H-151 Chemical Structure
  62. GC63012 IACS-8803 diammonium IACS-8803 diammonium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 diammonium has a robust systemic antitumor efficacy. IACS-8803 diammonium Chemical Structure
  63. GC62586 IACS-8803 disodium IACS-8803 disodium is a highly potent cyclic dinucleotide STING agonist. IACS-8803 disodium has a robust systemic antitumor efficacy. IACS-8803 disodium Chemical Structure
  64. GC43894 IKK2 Inhibitor VI

    5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

    Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.

     IKK2 Inhibitor VI Chemical Structure
  65. GC52291 KAS 08 A STING activator KAS 08 Chemical Structure
  66. GC91789 LB244 LB244 is an irreversible STING antagonist. LB244 Chemical Structure
  67. GC49673 M04 A STING agonist M04 Chemical Structure
  68. GC18988 ML RR-S2 CDA (ammonium salt)

    STING Inducer-1

     ML RR-S2 CDA (ammonium salt) (MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity. ML RR-S2 CDA (ammonium salt) Chemical Structure
  69. GC61092 MSA-2

    5,6-dimethoxy-γ-oxo-benzobthiophene-2-Butanoic Acid

     MSA-2 is an orally available non-nucleotide interferon gene stimulator (STING) agonist, with EC50 values of 8.3μM and 24μM for human STING subtypes WT and HAQ, respectively. MSA-2 Chemical Structure
  70. GC63082 MSA-2 dimer MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer Chemical Structure
  71. GC44388 NF-κB Control

    SN50M

     NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. NF-κB Control Chemical Structure
  72. GC48985 NF-κB Inhibitor (trifluoroacetate salt)

    SN50 Peptide

     A cell-permeable peptide that blocks nuclear import of NF-κB NF-κB Inhibitor (trifluoroacetate salt) Chemical Structure
  73. GC91777 NVS-STG2 NVS-STG2 is an agonist of stimulator of interferon genes (STING). NVS-STG2 Chemical Structure
  74. GC13693 Omaveloxolone (RTA-408)

    Omaveloxolone

     Omaveloxolone (RTA-408) (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone (RTA-408) Chemical Structure
  75. GC91595 PDIC-NC PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent. PDIC-NC Chemical Structure
  76. GC91688 PDIC-NN PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity. PDIC-NN Chemical Structure
  77. GC91820 PDIC-NS PDIC-NS is an activator of stimulator of interferon genes (STING). PDIC-NS Chemical Structure
  78. GC66392 PROTAC STING Degrader-1 PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity. PROTAC STING Degrader-1 Chemical Structure
  79. GC91096 S-72

    An inhibitor of microtubule polymerization

     S-72 Chemical Structure
  80. GC67719 SN-001 SN-001 Chemical Structure
  81. GC63905 SN-008 SN-008, a less active SN-011 analog, can be used as a negative control. SN-008 Chemical Structure
  82. GC49400 SN-011

    GUN35901

     A STING antagonist SN-011 Chemical Structure
  83. GC73865 SNX281 SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. SNX281 Chemical Structure
  84. GC61293 SR-717

    SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, Antitumor activity.

     SR-717 Chemical Structure
  85. GC44948 StA-IFN-1 StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1, which specifically inhibits the IKKβ component of the IFN induction pathway. StA-IFN-1 Chemical Structure
  86. GC48109 STING Agonist 12b A STING agonist STING Agonist 12b Chemical Structure
  87. GC90784 STING Agonist 12L

    A STING agonist

     STING Agonist 12L Chemical Structure
  88. GC48110 STING Agonist 1a STING Agonist 1a (1a) is a specific stimulator of interferon genes (STING) agonist. STING Agonist 1a Chemical Structure
  89. GC90785 STING Agonist 23

    A STING agonist

     STING Agonist 23 Chemical Structure
  90. GC45570 STING Agonist C11   STING Agonist C11 Chemical Structure
  91. GC90982 STING Agonist D61

    A STING agonist

     STING Agonist D61 Chemical Structure
  92. GC12943 STING agonist-1

    STING Agonist-1

     An indirect activator of STING signaling STING agonist-1 Chemical Structure
  93. GC65282 STING agonist-12

    STING Agonist-12

     STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. STING agonist-12 Chemical Structure
  94. GC73098 STING agonist-17 STING agonist-17 (compound 4a) is a potent STING agonist with an IC50 value of 0.062 nM. STING agonist-17 Chemical Structure
  95. GC69959 STING agonist-20

    STING agonist-20 (compound 95) is an effective STING agonist used in the synthesis of XMT-2056. It can be used as a vaccine adjuvant for cancer, inflammation, and research on immune diseases.

     STING agonist-20 Chemical Structure
  96. GC69961 STING agonist-22

    STING agonist-22 (CF501) is an effective non-nucleotide STING agonist.

     STING agonist-22 Chemical Structure
  97. GC73407 STING agonist-26 STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-26 Chemical Structure
  98. GC37692 STING agonist-3

    CS-0029879, Diamidobenzimidazole STING Agonist, diABZI-3, EX-A3217, HY-103665, STING Agonist-3

     STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-moleculeSTINGagonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer. STING agonist-3 Chemical Structure
  99. GC69962 STING agonist-3 trihydrochloride

    STING agonist-3 trihydrochloride is derived from patent WO2017175147A1 (Example 10) and is a selective and non-nucleotide small molecule STING agonist with pEC50 and pIC50 values of 7.5 and 9.5, respectively. It has long-lasting anti-tumor effects and holds great potential in improving cancer research.

     STING agonist-3 trihydrochloride Chemical Structure
  100. GC37693 STING agonist-4

    CS-0087594, Diamidobenzimidazole STING Agonist-2, diABZI-4, HY-123943, STING Agonist-4, STING Agonist diABZI Compound 2

     A STING agonist STING agonist-4 Chemical Structure
  101. GC66008 STING agonist-7 STING agonist-7 is a non-nucleotide STING agonist. STING agonist-7 binds selectively to mouse STING but not human STING. STING agonist-7 penetrates cell membrane poorly. STING agonist-7 Chemical Structure

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