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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> CRAC Channel

CRAC Channel

The Ca2+ release-activated Ca2+ (CRAC) channel is a highly Ca2+-selective store-operated channel expressed in T cells, mast cells, and various other tissues. CRAC channels regulate critical cellular processes such as gene expression, motility, and the secretion of inflammatory mediators. The identification of Orai1, a key subunit of the CRAC channel pore, and STIM1, the endoplasmic reticulum (ER) Ca2+ sensor, have provided the tools to illuminate the mechanisms of regulation and the pore properties of CRAC channels. Opening of CRAC channels enables the refilling of ER Ca2+ stores and sustains long-lasting Ca2+ oscillations and plateau signals, critical for the proliferation of T cells and production of cytokines following antigenic stimulation.

Targets for  CRAC Channel

Products for  CRAC Channel

  1. Cat.No. Product Name Information
  2. GC50179 5J 4 CRAC channel blocker; anti-inflammatory 5J 4 Chemical Structure
  3. GC19107 CM-4620

    CM-4620

     CM-4620 (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC50s of 119 nM and 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. CM-4620 Chemical Structure
  4. GC31852 CRAC intermediate 1 CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9. CRAC intermediate 1 Chemical Structure
  5. GC30361 CRAC intermediate 2 CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis, extracted from patent WO 2013059666A1. CRAC intermediate 2 Chemical Structure
  6. GC31680 GSK-5498A GSK-5498A is a selective CARC channel inhibitor (IC50: 1 μM). GSK-5498A Chemical Structure
  7. GC11683 MRS 1845 store-operated Ca2+ channels blocker MRS 1845 Chemical Structure
  8. GC65999 piCRAC-1 piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage. piCRAC-1 Chemical Structure
  9. GC60327 RO2959 hydrochloride RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride Chemical Structure
  10. GC61248 RO2959 monohydrochloride RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride Chemical Structure
  11. GC37658 SOCE inhibitor 1 SOCE inhibitor 1 is a store-operated calcium entry (SOCE) inhibitor with an IC50 of 4.4 μM. SOCE inhibitor 1 Chemical Structure
  12. GC33472 Synta66 Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease. Synta66 Chemical Structure
  13. GN10809 Tanshinone IIA sulfonate sodium

    Sodium Tanshinone IIA sulfonate, Sulfotanshinone sodium II-A

     Tanshinone IIA sulfonate sodium Chemical Structure
  14. GC14665 YM 58483

    BTP 2

     store-operated Ca2+ entry (SOCE) blocker YM 58483 Chemical Structure

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