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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

TRP Channel

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products for  TRP Channel

  1. Cat.No. Product Name Information
  2. GC10873 α-Spinasterol

    Bessisterol, Hitodesterol

     TRPV1 antagonist α-Spinasterol Chemical Structure
  3. GC40808 (+)-Menthol

    D-Menthol

     (+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. (+)-Menthol Chemical Structure
  4. GC34951 (-)-Menthol

    L-Menthol, (1R,2S,5R)-(-)-Menthol, NSC 62788

     A monoterpene with diverse biological activities (-)-Menthol Chemical Structure
  5. GC64062 (1R,2R)-ML-SI3

    (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.

     (1R,2R)-ML-SI3 Chemical Structure
  6. GC73042 (1S,2S)-ML-SI3

    (+)-trans-ML-SI3

     (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 Chemical Structure
  7. GC40696 (R)-(+)-Pulegone

    NSC 15334, D-Pulegone

     (R)-(+)-Pulegone, the major chemical constituent of Calamintha nepeta (L. (R)-(+)-Pulegone Chemical Structure
  8. GC73075 (rel)-ML-SI3

    trans-ML-SI3

     (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 Chemical Structure
  9. GC35010 (Z)-Capsaicin (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain. (Z)-Capsaicin Chemical Structure
  10. GC38726 1,4-Cineole 1,4-Cineole is a widely distributed, natural, oxygenated monoterpene. 1,4-Cineole Chemical Structure
  11. GC17562 2-APB

    2-Aminoethoxydiphenyl borate, 2-APB, NSC 17107

     2-APB is a nonspecific antagonist of calcium channels, commonly used in studies of calcium signaling, such as in apoptosis, muscle contraction, and neural transmission. 2-APB Chemical Structure
  12. GC68080 4-(Phenyldiazenyl)benzoic acid 4-(Phenyldiazenyl)benzoic acid Chemical Structure
  13. GC16801 5'-Iodoresiniferatoxin TRPV1 (VR1) receptor antagonist 5'-Iodoresiniferatoxin Chemical Structure
  14. GC10188 6'-Iodoresiniferatoxin TRPV1 (VR1) vanilloid receptor partial agonist 6'-Iodoresiniferatoxin Chemical Structure
  15. GC13679 6-Iodonordihydrocapsaicin Vanilloid receptor antagonist 6-Iodonordihydrocapsaicin Chemical Structure
  16. GC60542 8-Gingerol A natural TRPV1 agonist 8-Gingerol Chemical Structure
  17. GC10221 9-Phenanthrol

    9-Hydroxyphenanthrene, NSC 50554

     TRPM4 blocker 9-Phenanthrol Chemical Structure
  18. GC50261 A 425619 Potent TRPV1 antagonist A 425619 Chemical Structure
  19. GC17091 A 784168 TRPV1 antagonist,potent and selective A 784168 Chemical Structure
  20. GC11701 A 967079 Selective TRPA1 channel blocker A 967079 Chemical Structure
  21. GC30837 A-1165442 A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1. A-1165442 Chemical Structure
  22. GC35222 ABT-239 ABT-239 is a novel, highly efficacious, non-imidazole?class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist. ABT-239 Chemical Structure
  23. GC40860 AC1903 AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 μM). AC1903 Chemical Structure
  24. GC19729 Adenosine 5′-diphosphoribose sodium

    ADP ribose sodium

     Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  25. GC50475 AM 12

    TRPC5 inhibitor

     AM 12 Chemical Structure
  26. GC19025 AM-0902 AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively. AM-0902 Chemical Structure
  27. GC50058 AMG 21629 Potent and selective TRPV1 antagonist AMG 21629 Chemical Structure
  28. GC65611 AMG 333 AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. AMG 333 Chemical Structure
  29. GC11926 AMG 9810 TRPV1 antagonist AMG 9810 Chemical Structure
  30. GC13003 AMG-517 TRPV1 antagonist,potent and highly selective AMG-517 Chemical Structure
  31. GC35316 AMG2850 AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist. AMG2850 Chemical Structure
  32. GC14537 AMTB hydrochloride TRPM8 channel blocker AMTB hydrochloride Chemical Structure
  33. GC18020 AP 18

    Reversible TRPA1 channel blocker

     AP 18 Chemical Structure
  34. GC35407 Asivatrep

    PAC-14028

     Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist. Asivatrep Chemical Structure
  35. GC50115 ASP 7663 Selective TRPA1 activator ASP 7663 Chemical Structure
  36. GC68735 BAY-390

    BAY-390 is a selective, cross-species active, and brain-penetrant TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50 values of 16, 82, 63 and 35 nM respectively. BAY-390 can be used for research on inflammation.

     BAY-390 Chemical Structure
  37. GC14276 BCTC vanilloid receptor 1 (TRPV1 receptor) antagonist BCTC Chemical Structure
  38. GC35501 Beta-Eudesmol

    (+)-β-Eudesmol

     A sesquiterpene with diverse biological activities Beta-Eudesmol Chemical Structure
  39. GC34489 BI-749327 BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 Chemical Structure
  40. GC50617 BTD Selective TRPC5 activator BTD Chemical Structure
  41. GN10792 Caffeic acid

    3,4-Dihydroxycinnamic Acid

     Caffeic acid Chemical Structure
  42. GC31953 Camphor ((±)-Camphor) Camphor ((±)-Camphor) ((±)-Camphor ((±)-Camphor)) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. Camphor ((±)-Camphor) Chemical Structure
  43. GC14065 Capsaicin Capsaicin is a highly selective agonist for the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), a ligand-gated, nonselective cation channel, preferentially expressed on small-diameter sensory neurons. Capsaicin Chemical Structure
  44. GC17918 Capsazepine Capsazepine is a specific antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor with an IC50 value of 562nM. Capsazepine Chemical Structure
  45. GC18069 Cardamonin

    Alpinetin chalcone, Cardamomin

     Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. Cardamonin Chemical Structure
  46. GC50557 CBA

    CBA, Transient Receptor Potential Melastatin 4 Inhibitor 5, TRPM4 Inhibitor 5

     CBA (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. CBA Chemical Structure
  47. GC50188 CIM 0216 Selective TRPM3 agonist CIM 0216 Chemical Structure
  48. GC62179 Cyclic ADP-ribose Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose Chemical Structure
  49. GC61792 Cyclic ADP-ribose ammonium

    cADPR ammonium

     Cyclic ADP-ribose ammonium Chemical Structure
  50. GC33158 D-3263 D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. D-3263 Chemical Structure
  51. GC32961 D-3263 hydrochloride D-3263 hydrochloride is an enteric-coated, orally bioavailable (transient receptor potential melastatin member 8) TRPM8 agonist. D-3263 hydrochloride Chemical Structure
  52. GC67739 D-erythro-Sphingosine hydrochloride

    Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride

     D-erythro-Sphingosine hydrochloride Chemical Structure
  53. GC50670 D-GsMTx4 D-GsMTx4 Chemical Structure
  54. GC67924 Dihydrocapsiate Dihydrocapsiate Chemical Structure
  55. GC12520 Diphenyleneiodonium chloride

    DPI

     Diphenyleneiodonium (DPI) chloride (DPIC), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mtb and S. Diphenyleneiodonium chloride Chemical Structure
  56. GC15893 EIPA

    L-593,754, MH 12-43, 5-(N-ethyl-N-isopropyl)-Amiloride

     EIPA inhibited TRPP3-mediated Ca2+-activated currents with IC50 values of 10.5 µM. EIPA Chemical Structure
  57. GC35970 EIPA hydrochloride

    L593754 hydrochloride; MH 12-43 hydrochloride

    EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM.

     EIPA hydrochloride Chemical Structure
  58. GC70305 Elismetrep Elismetrep (MT-8554) is an oral active TRPM8 inhibitor, and can be used for study of analgesic. Elismetrep Chemical Structure
  59. GC64459 Englerin A Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload. Englerin A Chemical Structure
  60. GC66016 Evifacotrep Evifacotrep, a short transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep Chemical Structure
  61. GC66436 FEMA 4809 FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception. FEMA 4809 Chemical Structure
  62. GC70412 GDC-0334 GDC-0334 is a selective TRPA1 antagonist. GDC-0334 Chemical Structure
  63. GC71398 GDC-6599 GDC-6599 (Example 8) is an orally active TRPA1 inhibitor. GDC-6599 Chemical Structure
  64. GC16917 GSK 2193874 TRPV4 antagonist, potent and selective GSK 2193874 Chemical Structure
  65. GC17940 GSK1016790A GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A Chemical Structure
  66. GC39198 GSK1702934A A TRPC3 and TRPC6 activator GSK1702934A Chemical Structure
  67. GC38501 GSK205 GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19? μM for inhibiting TRPV4-mediated Ca2+ influx. GSK205 Chemical Structure
  68. GC38465 GsMTx4 GsMTx4 is a 34 amino acid spider venom peptide and belongs to the huwentoxin-1 family. GsMTx4 Chemical Structure
  69. GC12260 HC 067047 TRPV4 antagonist HC 067047 Chemical Structure
  70. GC15947 HC-030031 HC-030031 is a selective inhibitor of transient receptor potential ankyrin subfamily member 1 (TRPA1). HC-030031 blocks calcium influx in cells, with IC50 values of 4.9±0.1 and 7.5±0.2μM for calcium influx induced by cinnamaldehyde and allyl isothiocyanate (AITC), respectively. HC-030031 Chemical Structure
  71. GC30799 HC-070 HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. HC-070 Chemical Structure
  72. GC36277 Hydroxy-α-sanshool Hydroxy-α-sanshool is a transient receptor potential base 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50 values of 69 and 1.1µM, respectively, commonly used in hyperlipidemia studies. Hydroxy-α-sanshool Chemical Structure
  73. GC43884 Hyperforin (dicyclohexylammonium salt)

    Hyp-DCHA, Hyperforin-DCHA

     Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 μg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 μg/ml for CYP2D6). Hyperforin (dicyclohexylammonium salt) Chemical Structure
  74. GC50641 IA-Alkyne Broad spectrum cysteine reactive probe IA-Alkyne Chemical Structure
  75. GC16882 Icilin

    AG 35

     TRPM8/ hENaCδ agonist Icilin Chemical Structure
  76. GN10437 Imperatorin

    Marmelosin, NSC 402949

     Imperatorin Chemical Structure
  77. GC65006 JNc-440 JNc-440 is a potent antihypertensive agent. JNc-440 Chemical Structure
  78. GC15427 JNJ 17203212 TRPV1 antagonist JNJ 17203212 Chemical Structure
  79. GC69317 JNJ-28583113

    JNJ-28583113 is a brain-penetrant TRPM2 antagonist. It inhibits the phosphorylation of GSK3α and β subunits by blocking TRPM2. JNJ-28583113 protects cells from oxidative stress-induced cell death. It also inhibits the release of cytokines from microglia in response to pro-inflammatory stimuli.

     JNJ-28583113 Chemical Structure
  80. GC33423 JT010 A TRPA1 channel agonist JT010 Chemical Structure
  81. GC31236 JYL 1421 (SC 0030)

    SC 0030

     JYL 1421 (SC 0030) is a TRPV1 receptor antagonist, with an IC50 of 8 nM. JYL 1421 (SC 0030) Chemical Structure
  82. GC11613 L-R4W2 Vanilloid TRPV1 (VR1) receptor antagonist peptide L-R4W2 Chemical Structure
  83. GC44075 Linopirdine

    DuP-996

     Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. Linopirdine Chemical Structure
  84. GC50268 M 084 hydrochloride TRPC4/5 channel blocker; antidepressant and anxiolytic M 084 hydrochloride Chemical Structure
  85. GC18296 M8-B (hydrochloride) M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). M8-B (hydrochloride) Chemical Structure
  86. GC14761 Mavatrep

    JNJ-39439335

     TRPV1 antagonist Mavatrep Chemical Structure
  87. GC69450 Mesendogen

    Mesendogen is a TRPM6 inhibitor. It promotes mesoderm and endoderm differentiation of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs). Mesendogen can be used for studying magnesium homeostasis during early embryonic cell development.

     Mesendogen Chemical Structure
  88. GC39117 Methyl syringate Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate Chemical Structure
  89. GC36609 Mifamurtide Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide Chemical Structure
  90. GC18564 MK6-83 MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). MK6-83 Chemical Structure
  91. GC13457 ML 204

    CID230710, 2-piperidino-Lepidine, NSC 25850

     TRPC4 channels blocker ML 204 Chemical Structure
  92. GC16850 ML SA1

    Mucolipin synthetic agonist 1

     activator of TRPML channels ML SA1 Chemical Structure
  93. GC69478 ML-SA5

    ML-SA5 is a potent TRPML1 cation channel agonist that can activate the entire intracellular TRPML1 (ML1) current in DMD muscle cells, with an EC50 value of 285 nM, which is more effective than ML-SA1. ML-SA5 has anti-cancer activity and can inhibit tumor growth.

     ML-SA5 Chemical Structure
  94. GC67784 ML-SI3 ML-SI3 Chemical Structure
  95. GC36627 ML204 hydrochloride ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels. ML204 hydrochloride Chemical Structure
  96. GC69508 MSP-3

    MSP-3 is an effective TRPV1 agonist with an EC50 value of 0.87 μM. MSP-3 has neuroprotective effects.

     MSP-3 Chemical Structure
  97. GC13930 N-(p-amylcinnamoyl) Anthranilic Acid

    ACA

    phospholipase A2 (PLA2) inhibitor and TRP channel blocker

     N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure
  98. GC12769 Nonivamide

    Nonanoic Acid Vanillylamide, NSC 172795, Pelargonic Acid Vanillylamide, Pseudocapsaicin, N-Vanillylnonanamide, N-Vanillylpelargonamide

    agonist of the VR1 (TRPV1)

     Nonivamide Chemical Structure
  99. GC17879 OLDA

    N-Oleoyldopamine

     OLDA (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous TRPV1 selective agonist. OLDA Chemical Structure
  100. GC16467 Olvanil

    NE 19550, NVanillyloleamide

     vanilloid receptor agonist Olvanil Chemical Structure
  101. GC11906 Ononetin

    NSC 89759

     TRPM3 channel blocker Ononetin Chemical Structure

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