STAT
STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.
Products for STAT
- Cat.No. Product Name Information
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GC69952
STAT3-IN-11
STAT3-IN-11 (7a) is a selective inhibitor of STAT3 that can inhibit the phosphorylation of the pTyr705 site on STAT3. It can also inhibit downstream genes (Survivin and Mcl-1) without affecting upstream tyrosine kinases (Src and JAK2) and p-STAT1 expression. STAT3-IN-11 can induce apoptosis in cancer cells, making it a promising candidate for the discovery of STAT3 inhibitors and anti-tumor agents.
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GC69953
STAT3-IN-12
STAT3-IN-12 is an effective STAT3 signaling inhibitor that can suppress the activation of the IL-6-induced JAK/STAT3 signaling pathway. It can inhibit cancer cell growth and migration, induce apoptosis (cell death), and block cell cycle progression. STAT3-IN-12 can be used in cancer-related research such as hepatocellular carcinoma (HCC) and esophageal cancer.
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GC71187
STAT3-IN-15
STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF).
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GC37689
STAT3-IN-3
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.
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GC13647
STAT5 Inhibitor
Signal Transducers and Activators of Transcription 5
STAT5 Inhibitor is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform. -
GC65344
STAT5-IN-2
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.
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GC71018
STAT6-IN-1
STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM).
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GC71291
STAT6-IN-3
STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC50= 44 nM).
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GC17886
Stattic
STAT3 Inhibitor V
Stattic is the first non-peptide small molecule inhibitor of STAT3, which effectively inhibits STAT3 activation and nuclear translocation. -
GC67779
STX-0119
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GC39022
Tetramethylcurcumin
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain.
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GC17621
TPCA-1
A selective inhibitor of IKK2
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GN10282
Vitexicarpin (Casticin)
Vitexicarpin
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GC70140
W1131
W1131 is an effective STAT3 inhibitor that can induce ferroptosis. W1131 inhibits cancer progression in gastric cancer subcutaneous xenograft models, organoid models, and PDX models. W1131 effectively reduces chemoresistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation pathways including the IL6-JAK-STAT3 pathway and ferroptosis pathway.
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GC15980
WP1066
STAT Inhibitor III
An inhibitor of STAT3
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GC64891
YM-341619
AS1617612
YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM.