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Home >> Signaling Pathways >> JAK/STAT Signaling >> STAT

STAT

STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.

Products for  STAT

  1. Cat.No. Product Name Information
  2. GC69952 STAT3-IN-11

    STAT3-IN-11 (7a) is a selective inhibitor of STAT3 that can inhibit the phosphorylation of the pTyr705 site on STAT3. It can also inhibit downstream genes (Survivin and Mcl-1) without affecting upstream tyrosine kinases (Src and JAK2) and p-STAT1 expression. STAT3-IN-11 can induce apoptosis in cancer cells, making it a promising candidate for the discovery of STAT3 inhibitors and anti-tumor agents.

     STAT3-IN-11 Chemical Structure
  3. GC69953 STAT3-IN-12

    STAT3-IN-12 is an effective STAT3 signaling inhibitor that can suppress the activation of the IL-6-induced JAK/STAT3 signaling pathway. It can inhibit cancer cell growth and migration, induce apoptosis (cell death), and block cell cycle progression. STAT3-IN-12 can be used in cancer-related research such as hepatocellular carcinoma (HCC) and esophageal cancer.

     STAT3-IN-12 Chemical Structure
  4. GC71187 STAT3-IN-15 STAT3-IN-15 is a potent and orally active STAT3 inhibitor against idiopathic pulmonary fibrosis (IPF). STAT3-IN-15 Chemical Structure
  5. GC37689 STAT3-IN-3 STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research. STAT3-IN-3 Chemical Structure
  6. GC13647 STAT5 Inhibitor

    Signal Transducers and Activators of Transcription 5

     STAT5 Inhibitor is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform. STAT5 Inhibitor Chemical Structure
  7. GC65344 STAT5-IN-2 STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect. STAT5-IN-2 Chemical Structure
  8. GC71018 STAT6-IN-1 STAT6-IN-1 (compound 19a) is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). STAT6-IN-1 Chemical Structure
  9. GC71291 STAT6-IN-3 STAT6-IN-3 (Compound 18a) is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 Chemical Structure
  10. GC17886 Stattic

    STAT3 Inhibitor V

     Stattic is the first non-peptide small molecule inhibitor of STAT3, which effectively inhibits STAT3 activation and nuclear translocation. Stattic Chemical Structure
  11. GC67779 STX-0119 STX-0119 Chemical Structure
  12. GC39022 Tetramethylcurcumin Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin Chemical Structure
  13. GC17621 TPCA-1 A selective inhibitor of IKK2 TPCA-1 Chemical Structure
  14. GN10282 Vitexicarpin (Casticin)

    Vitexicarpin

     Vitexicarpin (Casticin) Chemical Structure
  15. GC70140 W1131

    W1131 is an effective STAT3 inhibitor that can induce ferroptosis. W1131 inhibits cancer progression in gastric cancer subcutaneous xenograft models, organoid models, and PDX models. W1131 effectively reduces chemoresistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation pathways including the IL6-JAK-STAT3 pathway and ferroptosis pathway.

     W1131 Chemical Structure
  16. GC15980 WP1066

    STAT Inhibitor III

    An inhibitor of STAT3

     WP1066 Chemical Structure
  17. GC64891 YM-341619

    AS1617612

     YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 Chemical Structure

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