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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling

Targets for  MAPK Signaling

Products for  MAPK Signaling

  1. Cat.No. Product Name Information
  2. GC62504 RAS/RAS-RAF-IN-1 RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity. RAS/RAS-RAF-IN-1 Chemical Structure
  3. GC37071 Ravoxertinib hydrochloride

    GDC-0994 hydrochloride

     Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. Ravoxertinib hydrochloride Chemical Structure
  4. GC16872 Refametinib

    BAY 869766; RDEA119;

    MEK 1/ MEK 2 inhibitor

     Refametinib Chemical Structure
  5. GC37516 Refametinib R enantiomer Refametinib R enantiomer is a MEK inhibitor extracted from patent WO2007014011A2, compound 1022, has an EC50 of 2.0-15 nM. Refametinib R enantiomer Chemical Structure
  6. GC14606 Regorafenib hydrochloride A multi-kinase inhibitor Regorafenib hydrochloride Chemical Structure
  7. GC14534 Regorafenib monohydrate A multi-kinase inhibitor Regorafenib monohydrate Chemical Structure
  8. GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib-13C-d3 Chemical Structure
  9. GC18751 Reticulol

    6,8-dihydroxy-7-methoxy-3-methyl Isocoumarin, NSC 294978

     Reticulol is an isocoumarin derivative produced by certain species of Streptomyces that inhibits cAMP phosphodiesterase (IC50 = 41 uM). Reticulol Chemical Structure
  10. GC37522 RGB-286638 A multi-kinase inhibitor RGB-286638 Chemical Structure
  11. GC37523 RGB-286638 free base A multi-kinase inhibitor RGB-286638 free base Chemical Structure
  12. GN10784 Rhoifolin

    Apigenin 7-O-Neohesperidoside

     Rhoifolin Chemical Structure
  13. GC50502 RI-STAD 2 AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable RI-STAD 2 Chemical Structure
  14. GC62448 Rineterkib hydrochloride Rineterkib hydrochloride (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. Rineterkib hydrochloride Chemical Structure
  15. GC69821 RLX-33

    RLX-33 is an effective and selective relaxin family peptide 3 (RXFP3) antagonist with blood-brain barrier permeability. It also blocks the phosphorylation of ERK1/2 induced by relaxin 3, with IC50 values for RXFP3, ERK1, and ERK2 phosphorylation being 2.36 μM, 7.82 μM, and 13.86 μM respectively. RLX-33 can block the increase in food intake induced by the RXFP3 selective agonist R3/I5 in rats. RLX-33 can be used for research on metabolic syndrome.

     RLX-33 Chemical Structure
  16. GC50294 RMM 46 MSK/RSK family kinase inhibitor RMM 46 Chemical Structure
  17. GC12141 RO4987655

    CH4987655

     MEK inhibitor RO4987655 Chemical Structure
  18. GC12406 RO5126766(CH5126766)

    CH5126766, VS-6766

     RO5126766(CH5126766) (CH5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively). RO5126766(CH5126766) Chemical Structure
  19. GC38609 Rotundic acid Rotundic acid, a triterpenoid obtained from I. Rotundic acid Chemical Structure
  20. GC15611 Rp-8-Br-PET-cGMPS

    Rp-8-bromo-PET-cGMPS

     cGMP-dependent protein kinase (PKG) inhibitor Rp-8-Br-PET-cGMPS Chemical Structure
  21. GC44852 Rp-8-bromo-Cyclic AMPS (sodium salt)

    8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer, Rp-8-BrcAMPS, Rp-8-bromocAMPS

     Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. Rp-8-bromo-Cyclic AMPS (sodium salt) Chemical Structure
  22. GC44853 Rp-8-CPT-Cyclic AMP (sodium salt)

    Rp-8-CPT-cAMP

     Rp-8-CPT-Cyclic AMP (sodium salt), a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-Cyclic AMP (sodium salt) Chemical Structure
  23. GC63176 Rp-cAMPS sodium salt Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 ?M and 4.5 ?M, respectively) antagonist. Rp-cAMPS sodium salt Chemical Structure
  24. GC62269 RRD-251 RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities. RRD-251 Chemical Structure
  25. GC13142 RWJ 67657

    JNJ-3026582

     orally active inhibitor of the MAP kinases p38α and p38β RWJ 67657 Chemical Structure
  26. GC71682 Salbutamol Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol Chemical Structure
  27. GC18273 SB 202190 (hydrochloride) SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. SB 202190 (hydrochloride) Chemical Structure
  28. GC16019 SB 202474 a negative control in studies of p38 inhibition SB 202474 Chemical Structure
  29. GC13001 SB 203580 hydrochloride

    PB 203580, RWJ 64809

     Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride Chemical Structure
  30. GC10054 SB 239063 A selective p38 MAPK inhibitor SB 239063 Chemical Structure
  31. GC37595 SB 242235 SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC50 of 1.0　μM in primary human chondrocytes. SB 242235 Chemical Structure
  32. GC11922 SB 706504 p38 MAPK inhibitor SB 706504 Chemical Structure
  33. GC13968 SB202190 (FHPI) SB202190 (FHPI) is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB202190 (FHPI) Chemical Structure
  34. GC11890 SB590885 Potent B-Raf inhibitor SB590885 Chemical Structure
  35. GC16001 SCH772984 SCH772984 is a novel, potent, ATP-competitive inhibitor of ERK1 and ERK2 with IC50 values of 4nM and 1nM, respectively. SCH772984 Chemical Structure
  36. GC14647 SCH772984 HCl

    ERK1/2 inhibitor

     SCH772984 HCl Chemical Structure
  37. GC15044 SCH772984 TFA

    ERK1/2 inhibitor

     SCH772984 TFA Chemical Structure
  38. GC19325 SD 0006

    SD-006

     SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po).IC50 value: 170 nM. SD 0006 Chemical Structure
  39. GC14982 SD 169

    5-Carbamoylindole

     selective ATP competitive inhibitor of the MAP kinases p38α and p38β SD 169 Chemical Structure
  40. GC12124 Selonsertib (GS-4997)

    GS-4977, GS-4997

     Selonsertib (GS-4997) (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) Chemical Structure
  41. GC38653 Selumetinib sulfate Selumetinib (AZD6244) is selective, non-ATP-competitive oral?MEK1/2?inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib sulfate Chemical Structure
  42. GC39815 Semapimod tetrahydrochloride

    CNI-1493; CPSI-2364 tetrahydrochloride

     Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride Chemical Structure
  43. GC10005 SEP-0372814 A PDE10A inhibitor SEP-0372814 Chemical Structure
  44. GC33229 SJFα SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16nM, but is far less effective at degrading p38δ (DC50=299nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5μM. SJFα Chemical Structure
  45. GC33238 SJFδ SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17nM, but does not degrade p38α, p38β, or p38γ. SJFδ Chemical Structure
  46. GC30646 Skatole(3-Methylindole)

    3-Methyl-1H-indole

     Skatole(3-Methylindole) is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Skatole(3-Methylindole) Chemical Structure
  47. GC13578 Skepinone-L

    Skepinone L

     An inhibitor of p38 MAPK Skepinone-L Chemical Structure
  48. GC17725 SKF 86002 dihydrochloride p38 MAP kinase inhibitor SKF 86002 dihydrochloride Chemical Structure
  49. GC37646 SKF-86002 SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 Chemical Structure
  50. GC18532 Skyrin

    Endothianin, Rhodophyscin

     Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. Skyrin Chemical Structure
  51. GC16313 SL 0101-1 ribosomal S6 kinase inhibitor SL 0101-1 Chemical Structure
  52. GC15359 SL-327 Selective MEK1/2 inhibitor SL-327 Chemical Structure
  53. GC32937 SLV-2436 (SEL201-88)

    SEL201-88; SEL-201

     SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively. SLV-2436 (SEL201-88) Chemical Structure
  54. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71 Chemical Structure
  55. GC17425 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Sodium Tauroursodeoxycholate (TUDC) Chemical Structure
  56. GC17369 Sorafenib

    BAY 43-9006

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

     Sorafenib Chemical Structure
  57. GC37664 Sorafenib (D3)

    BAY 43-9006-d3

     An internal standard for the quantification of sorafenib Sorafenib (D3) Chemical Structure
  58. GC37665 Sorafenib (D4)

    Bay 43-9006-d4

     Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4) Chemical Structure
  59. GC44917 Sorafenib N-oxide

    BAY 67-3472

     Sorafenib N-oxide is an active metabolite of sorafenib, an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide Chemical Structure
  60. GC10428 Sp-5,6-dichloro-cBIMPS (sodium salt)

    Sp-5,6-DCI-cBIMPS

     PKA activator Sp-5,6-dichloro-cBIMPS (sodium salt) Chemical Structure
  61. GC44920 Sp-8-bromo-Cyclic AMPS (sodium salt)

    8Bromoadenosine 3',5'cyclic Monophosphothioate SPIsomer, Sp8bromocAMPS

     Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. Sp-8-bromo-Cyclic AMPS (sodium salt) Chemical Structure
  62. GC61747 Sp-cAMPS Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS Chemical Structure
  63. GC16652 SR 3576

    JNK3 inhibitor, potent and selective

     SR 3576 Chemical Structure
  64. GC30864 SR-3306 SR-3306 is a selective, potent, highly brain penetrant JNK inhibitor. SR-3306 Chemical Structure
  65. GC64287 SR15006 SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells). SR15006 Chemical Structure
  66. GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable st-Ht31 Chemical Structure
  67. GC50407 st-Ht31 P Negative control for st-Ht31 st-Ht31 P Chemical Structure
  68. GC50501 STAD 2 AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable STAD 2 Chemical Structure
  69. GC15299 Staurosporine(CGP 41251)

    Stsp

     Staurosporin, a small kinase inhibitor, is an alkaloid derived from the bacterium Streptomyces staurosporeus. Staurosporine(CGP 41251) Chemical Structure
  70. GC11542 SU 3327

    SU 3327

     JNK inhibitor SU 3327 Chemical Structure
  71. GC13825 TA 01

    CK1ε, CK1δ,and p38α inhibitor

     TA 01 Chemical Structure
  72. GC11635 TA 02 p38 MAPK inhibitor TA 02 Chemical Structure
  73. GC16543 TAK-715 A p38 MAPK inhibitor TAK-715 Chemical Structure
  74. GC10209 TAK-733 MEK allosteric site inhibitor TAK-733 Chemical Structure
  75. GC62497 TAK1-IN-2 TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM. TAK1-IN-2 Chemical Structure
  76. GC69984 TAK1-IN-4

    TAK1-IN-4 (Compound 14) is a TAK1 inhibitor.

     TAK1-IN-4 Chemical Structure
  77. GC49700 Takeda-6d Takeda-6d Chemical Structure
  78. GC32687 Takinib

    EDHS-206

     A TAK1 inhibitor Takinib Chemical Structure
  79. GC34072 Talmapimod (SCIO-469)

    Talmapimod

     Talmapimod (SCIO-469) (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod (SCIO-469) shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. Talmapimod (SCIO-469) Chemical Structure
  80. GC25982 Tanzisertib(CC-930)

    JNK-930, JNKI-1

     Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. Tanzisertib(CC-930) Chemical Structure
  81. GC34181 Tauroursodeoxycholate (TUDCA)

    3α,7β-dihydroxy-5β-cholanoyl Taurine, TUDCA, UR-906

     Tauroursodeoxycholate (TUDCA) (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate (TUDCA) significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate (TUDCA) also inhibits ERK. Tauroursodeoxycholate (TUDCA) Chemical Structure
  82. GC34831 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate dihydrate Chemical Structure
  83. GC34057 TBHQ (tert-Butylhydroquinone) TBHQ(tert-Butylhydroquinone) is a powerful phenolic antioxidant capable of reducing oxidative stress and inflammatory reactions. TBHQ (tert-Butylhydroquinone) Chemical Structure
  84. GC14853 TC ASK 10 ASK1 inhibitor TC ASK 10 Chemical Structure
  85. GC34140 TC13172 TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells. TC13172 Chemical Structure
  86. GC11488 TCS JNK 5a

    cJun Nterminal Kinase Inhibitor IX, TCS JNK 5a

     JNK2 and JNK3 inhibitor TCS JNK 5a Chemical Structure
  87. GC17282 TCS JNK 6o

    JNK Inhibitor VIII

     TCS JNK 6o (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively. TCS JNK 6o Chemical Structure
  88. GC39074 Tenuifoliside A Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A Chemical Structure
  89. GC41573 Theaflavin 3,3'-digallate

    TF3, TFDG

     Theaflavin 3,3'-digallate (TF-3; ZP10) is a potent inhibitor of Zika virus (ZIKV) protease with an IC50 value of 2.3μM. Theaflavin 3,3'-digallate Chemical Structure
  90. GC68350 Tinlorafenib Tinlorafenib Chemical Structure
  91. GC50295 TL4-12 Potent MAP4K2 (GCK) inhibitor TL4-12 Chemical Structure
  92. GC31647 Tomatidine Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine Chemical Structure
  93. GC45064 Tomatidine (hydrochloride) Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. Tomatidine (hydrochloride) Chemical Structure
  94. GC19131 Tomivosertib eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib Chemical Structure
  95. GC45067 Tpl2 Kinase Inhibitor

    c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor

     Tpl2 Kinase Inhibitor (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers. Tpl2 Kinase Inhibitor Chemical Structure
  96. GC49150 Tpl2 Kinase Inhibitor (hydrochloride)

    c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor

     A Tpl2 inhibitor Tpl2 Kinase Inhibitor (hydrochloride) Chemical Structure
  97. GC70053 Trametiglue

    Trametiglue is a derivative of Trametinib that binds to KSR-MEK and RAF-MEK with unprecedented potency and selectivity through a unique interface interaction.

     Trametiglue Chemical Structure
  98. GC13508 Trametinib (GSK1120212)

    GSK1120212, JTP-74057

     Trametinib (GSK1120212, JTP-74057) is a second-generation small molecule inhibitor of MEK kinase. Trametinib (GSK1120212) Chemical Structure
  99. GC15260 Trametinib DMSO solvate Trametinib DMSO solvate Chemical Structure
  100. GC30162 trans-Zeatin A cytokinin plant growth regulator trans-Zeatin Chemical Structure
  101. GC45099 U-0126

    A MEK inhibitor

     U-0126 Chemical Structure

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