MeOSuc-Ala-Ala-Pro-Val-AMC (Synonyms: I 1270, MeOSucAAPVAMC, Methoxy SuccinylAlaAlaProValAMC) |
| Catalog No.GC44157 |
MeOSuc-Ala-Ala-Pro-Val-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (Km: 362 μM, Ex=380 nm, Em=460 nm).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72252-90-5
Sample solution is provided at 25 µL, 10mM.
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MeOSuc-Ala-Ala-Pro-Val-AMC (MeOSuc-AAPV-AMC) is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase. The methoxy succinyl (MeO-Suc) peptide AAPV is avidly hydrolyzed by these elastases but not by cathepsin G. The addition of 7-amino-4-methylcoumarin (AMC) generates a peptide of low fluorescence (excitation: 355-380 nm; emission 440-460 nm) that demonstrates a linear increase in fluorescence in the presence of elastase. This peptidyl-AMC substrate detects as little as 11 pM human leukocyte elastase and 18 pM porcine pancreatic elastase.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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