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Home >> Signaling Pathways >> Metabolism >> 5-Lipoxygenase

5-Lipoxygenase

5-lipoxygenase catalyzes oxidation of AA at the 5-position to yield 5-HpETE and is a current target for pharmaceutical intervention in a number of diseases such as asthma, atherosclerosis and several cancers.

Products for  5-Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC13379 1-Naphthyl 3,5-dinitrobenzoate

    1-(3,5-Dinitrobenzoyloxy)naphthalene,1-Naphthalonol 3,5-dinitrobenzoate

     dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor 1-Naphthyl 3,5-dinitrobenzoate Chemical Structure
  3. GC10821 11-keto-β-Boswellic Acid

    11-oxo-β-Boswellic acid,KBA

     11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production. 11-keto-β-Boswellic Acid Chemical Structure
  4. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     3-acetyl-11-keto-β-Boswellic Acid (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. 3-acetyl-11-keto-β-Boswellic Acid Chemical Structure
  5. GC14601 BW 755C dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways BW 755C Chemical Structure
  6. GC10331 Ebselen Ebselen is a selenoorganic compound with glutathione peroxidase-like activity and is an anti-inflammatory and antioxidant agent. Ebselen is an inhibitor of inositol monophosphatase (IMPase) with an IC50 of 1.5μM. Ebselen Chemical Structure
  7. GC12159 HZ52 5-lipoxygenase inhibitor HZ52 Chemical Structure
  8. GC14751 Malotilate

    NKK-105

     Stimulates hepatocyte regeneration Malotilate Chemical Structure
  9. GC16046 Piriprost (potassium salt)

    U-60257B

     5-lipoxygenase inhibitor Piriprost (potassium salt) Chemical Structure
  10. GC10451 U-73122 U-73122 is a potent and selective phospholipase C (PLC) inhibitor with an IC50 value of approximately 1-2.1µM. It also inhibits 5-lipoxygenase (5-LO). U-73122 Chemical Structure
  11. GC16014 Zileuton

    A 64077

    5-lipoxygenase (5-LOX) inhibitor, orally active

     Zileuton Chemical Structure
  12. GC14435 Zileuton sodium 5-lipoxygenase and leukotrienes inhibitor Zileuton sodium Chemical Structure

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