Necroptosis

Cat.No. Product Name Information

GC52126 8-chloro Caffeine

NSC 6277

GC65004 Apostatin-1

Apt-1

Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 Chemical Structure

GC43022 C14 Ceramide (d18:1/14:0)

Cer(d18:1/14:0)

C14 Ceramide is an endogenous ceramide generated by ceramide synthase 6.

C14 Ceramide (d18:1/14:0) Chemical Structure

GC49556 Cl-Necrostatin-1

7-Cl-Nec-1, 7-Cl-Necrostatin-1, Nec-1f

A RIPK1 inhibitor Cl-Necrostatin-1 Chemical Structure

GC69345 KWCN-41

KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41 specifically inhibits necroptosis but does not inhibit apoptosis. KWCN-41 also has anti-inflammatory effects.

GC40497 Necrostatin-1 Inactive Control

Nec-1i

Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1, a RIP1 kinase inhibitor.

Necrostatin-1 Inactive Control Chemical Structure

GC44359 Necrostatin-7

Nec7

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-7 Chemical Structure

GC49681 Necrosulfonamide-d4

NSA-d4

Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide. Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis. Necrosulfonamide-d4 Chemical Structure

GC49308 Ungeremine

Lycobetaine

A betaine-type alkaloid with diverse biological activities Ungeremine Chemical Structure

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