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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> DNA-PK

DNA-PK

DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

Products for  DNA-PK

  1. Cat.No. Product Name Information
  2. GC64818 AMA-37 AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively. AMA-37 Chemical Structure
  3. GC64938 AZD-7648 AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity. AZD-7648 Chemical Structure
  4. GC16654 CC-115 mTOR/DNA-PK inhibitor CC-115 Chemical Structure
  5. GC34121 CC-115 hydrochloride CC-115 hydrochloride is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. CC-115 hydrochloride Chemical Structure
  6. GC10812 Compound 401 DNA-PK and mTOR inhibitor Compound 401 Chemical Structure
  7. GC74026 DNA-PK-IN-12 DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 Chemical Structure
  8. GC10196 ETP-46464

    ATM Inhibitor III, ATR Inhibitor III

     ATR inhibitor,potent and selective ETP-46464 Chemical Structure
  9. GC14346 KU-0060648 Dual DNA-PK/PI3-K inhibitor, ATP-competitive KU-0060648 Chemical Structure
  10. GC19227 LTURM34

    LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

     LTURM34 Chemical Structure
  11. GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases LY 294002 hydrochloride Chemical Structure
  12. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations. LY3023414 Chemical Structure
  13. GC73792 Lys(CO-C3-p-I-Ph)-O-tBu Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu Chemical Structure
  14. GC73791 Lys(CO-C3-p-I-Ph)-OMe Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe Chemical Structure
  15. GC12332 NU 7026

    DNAPK Inhibitor II, LY293646

     DNPK inhibitor,ATP-competitive and potent NU 7026 Chemical Structure
  16. GC11251 NU7441 (KU-57788)

    KU 57788; NU-7441;KU57788;NU7441;NU 7441

     NU7441 (KU-57788) is a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 of 13nM. NU7441 also inhibits phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with IC50 of 5.0 and 1.7μM, respectively. NU7441 (KU-57788) Chemical Structure
  17. GC11165 PI-103 Class I PI3K, mTOR and DNA-PK inhibitor PI-103 Chemical Structure
  18. GC16904 PIK-75 PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. PIK-75 Chemical Structure
  19. GC17199 PIK-90

    PIK85

     PI3K inhibitor,potent selective PIK-90 Chemical Structure
  20. GC19328 SF2523 SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively. SF2523 Chemical Structure
  21. GC65249 STL127705 STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis. STL127705 Chemical Structure
  22. GC13858 Torin 2 MTOR inhibitor,highly potent and selective Torin 2 Chemical Structure
  23. GC33325 VX-984 (M9831)

    M9831

     VX-984 (M9831) (M9831) is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 (M9831) efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 (M9831) can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 (M9831) Chemical Structure
  24. GC19390 YU238259 YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research. YU238259 Chemical Structure

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