E3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
Targets for E3 Ligase Ligand-Linker Conjugate
Products for E3 Ligase Ligand-Linker Conjugate
- Cat.No. Product Name Information
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GC69944
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate containing the (S,R,S)-AHPC ligand, which can be used in PROTAC research.
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GC69945
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA
"(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA" is a synthetic E3 ligase ligand-linker conjugate, which includes a ligand based on (S,R,S)-AHPC and a three-unit PEG linker."
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GC62148
(S,R,S)-AHPC-amido-C5-acid
(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133.
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GC69946
(S,R,S)-AHPC-amido-C7-acid
(S,R,S)-AHPC-amido-C7-acid contains a VHL ligand for recruiting E3 ubiquitin ligases and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used for designing PROTACs.
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GC62684
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology. -
GC69947
(S,R,S)-AHPC-C10-NHBoc
(S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It can be used to synthesize targeted PROTACs for BET.
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GC69743
(S,R,S)-AHPC-C4-NH2 hydrochloride
VH032-C4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a VHL ligand based on (S,R,S)-AHPC and one linker. It is used for the synthesis of targeted PROTACs for EED.
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GC65133
(S,R,S)-AHPC-C5-COOH
VH032-C5-COOH
(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases. -
GC69948
(S,R,S)-AHPC-CO-C9-acid
VH032-NH-CO-C9-acid
"(S,R,S)-AHPC-CO-C9-acid" is a ligand-linker complex of E3 ligase, which can be attached to the ligand of a protein to form a PROTAC."
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GC67831
(S,R,S)-AHPC-Me-C10-Br
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GC64371
(S,R,S)-AHPC-Me-C10-NH2
(S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432.
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GC63494
(S,R,S)-AHPC-Me-C5-COOH
(S,R,S)-AHPC-Me-C5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C5-COOH can be used in PROTAC DT2216.
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GC67729
(S,R,S)-AHPC-Me-C6-NH2
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GC63561
(S,R,S)-AHPC-Me-C7 ester
(S,R,S)-AHPC-Me-C7 ester is a E3 ligase ligand-linker conjugate used to synthesise BCL-XL PROTAC degraders.
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GC62585
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 and PROTAC BRD4 Degrader-5-CO-PEG3-N3.
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GC62183
(S,R,S)-AHPC-O-Ph-PEG1-NH2
VH032-O-Ph-PEG1-NH2
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1. PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. -
GC61774
(S,R,S)-AHPC-PEG5-Boc
(S,R,S)-AHPC-PEG5-Boc is a E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for Cdc20 degrader CP5V.
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GC50466
A 410099.1, amine
A 410099.1, amine is afunctionalizedIAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5).
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GC68839
Cbl-b-IN-2
Cbl-b-IN-2 (Example 8) is an orally effective bioactive compound that inhibits the E3 enzyme Casitas b-lineage lymphoma proto-oncogene-b (Cbl-b) in the ubiquitin-proteasome pathway. Cbl-b-IN-2 can be used to modulate the immune system and diseases that are susceptible to immune system regulation. Cbl-b-IN-2 (Example 8) can also be used alone or in combination with one or more immune checkpoint inhibitors, anti-tumor agents, and radiation for cancer treatment.
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GC35931
E3 ligase Ligand 17
E3 ligase Ligand 17 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.
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GC34565
E3 ligase Ligand 8 hydrochloride
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GC34566
E3 ligase Ligand 9
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
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GC32779
E3 Ligase Ligand-Linker Conjugates 1
Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1
E3 Ligase Ligand-Linker Conjugates 1 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. -
GC32986
E3 ligase Ligand-Linker Conjugates 11
VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11
E3 ligase Ligand-Linker Conjugates 11 is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. E3 ligase Ligand-Linker Conjugates 11 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. -
GC33000
E3 ligase Ligand-Linker Conjugates 12
VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12
E3 ligase Ligand-Linker Conjugates 12 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. -
GC32888
E3 ligase Ligand-Linker Conjugates 13
VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13
E3 ligase Ligand-Linker Conjugates 13 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. -
GC32761
E3 ligase Ligand-Linker Conjugates 14
Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA
E3 ligase Ligand-Linker Conjugates 14 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. -
GC34365
E3 ligase Ligand-Linker Conjugates 15
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GC30064
E3 ligase Ligand-Linker Conjugates 16
Cereblon Ligand-Linker Conjugates 6 TFA; E3 ligase Ligand-Linker Conjugates 19 TFA
E3 ligase Ligand-Linker Conjugates 16 (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. -
GC30050
E3 ligase Ligand-Linker Conjugates 17
Cereblon Ligand -Linker Conjugates 2 TFA; E3 Ligase Ligand-Linker Conjugates 20 TFA
E3 ligase Ligand-Linker Conjugates 17 (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. -
GC30105
E3 ligase Ligand-Linker Conjugates 18
Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18
E3 ligase Ligand-Linker Conjugates 18 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. -
GC33129
E3 Ligase Ligand-Linker Conjugates 19
Cereblon Ligand-Linker Conjugates 6; E3 Ligase Ligand-Linker Conjugates 19
E3 Ligase Ligand-Linker Conjugates 19 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. -
GC32871
E3 Ligase Ligand-Linker Conjugates 2
Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2
E3 Ligase Ligand-Linker Conjugates 2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. -
GC33390
E3 Ligase Ligand-Linker Conjugates 20
Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20
E3 Ligase Ligand-Linker Conjugates 20 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. -
GC33103
E3 Ligase Ligand-Linker Conjugates 21
Cereblon Ligand-Linker Conjugates 3 ; E3 Ligase Ligand-Linker Conjugates 14
E3 Ligase Ligand-Linker Conjugates 21 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. -
GC32903
E3 Ligase Ligand-Linker Conjugates 22
Cereblon Ligand-Linker Conjugates 8; E3 Ligase Ligand-Linker Conjugates 22
E3 Ligase Ligand-Linker Conjugates 22 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. -
GC34334
E3 Ligase Ligand-Linker Conjugates 23 TFA
-
GC33473
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
Cereblon Ligand-Linker Conjugates 11 TFA; E3 Ligase Ligand-Linker Conjugates 25 TFA
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. -
GC33110
E3 ligase Ligand-Linker Conjugates 3
VH032-PEG1-N3; VHL Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 3
E3 ligase Ligand-Linker Conjugates 3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. -
GC35935
E3 ligase Ligand-Linker Conjugates 30
E3 ligase Ligand-Linker Conjugates 30 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
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GC35936
E3 ligase Ligand-Linker Conjugates 30 TFA
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GC35937
E3 ligase Ligand-Linker Conjugates 33
E3 ligase Ligand-Linker Conjugates 33
E3 ligase Ligand-Linker Conjugates 33 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 33 can be used to design SNIPERs. -
GC35938
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride
E3 ligase Ligand-Linker Conjugates 33 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 33 Hydrochloride can be used to design SNIPERs. -
GC35939
E3 ligase Ligand-Linker Conjugates 34
E3 ligase Ligand-Linker Conjugates 34
E3 ligase Ligand-Linker Conjugates 34 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 34 can be used to design SNIPERs. -
GC35940
E3 ligase Ligand-Linker Conjugates 34 Hydrochloride
E3 ligase Ligand-Linker Conjugates 34 hydrochloride
E3 ligase Ligand-Linker Conjugates 34 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 34 Hydrochloride can be used to design SNIPERs. -
GC35941
E3 ligase Ligand-Linker Conjugates 35 Hydrochlride
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GC35942
E3 ligase Ligand-Linker Conjugates 36
E3 ligase Ligand-Linker Conjugates 36
E3 ligase Ligand-Linker Conjugates 36 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 36 can be used to design SNIPERs. -
GC35943
E3 ligase Ligand-Linker Conjugates 37
E3 ligase Ligand-Linker Conjugates 37
E3 ligase Ligand-Linker Conjugates 37 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 37 can be used to design SNIPERs. -
GC35944
E3 ligase Ligand-Linker Conjugates 37 Hydrochloride
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GC35945
E3 ligase Ligand-Linker Conjugates 38
E3 ligase Ligand-Linker Conjugates 38
E3 ligase Ligand-Linker Conjugates 38 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 38 can be used to design SNIPERs. -
GC35946
E3 ligase Ligand-Linker Conjugates 39
E3 ligase Ligand-Linker Conjugates 39
E3 ligase Ligand-Linker Conjugates 39 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 39 can be used to design SNIPERs. -
GC30071
E3 ligase Ligand-Linker Conjugates 4
VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 4 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. -
GC35947
E3 ligase Ligand-Linker Conjugates 40
E3 ligase Ligand-Linker Conjugates 40
E3 ligase Ligand-Linker Conjugates 40 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 40 can be used to design SNIPERs. -
GC35948
E3 ligase Ligand-Linker Conjugates 41
E3 ligase Ligand-Linker Conjugates 41
E3 ligase Ligand-Linker Conjugates 41 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 41 can be used to design SNIPERs. -
GC35949
E3 ligase Ligand-Linker Conjugates 42
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GC35950
E3 ligase Ligand-Linker Conjugates 43
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GC35951
E3 ligase Ligand-Linker Conjugates 44
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GC35952
E3 ligase Ligand-Linker Conjugates 45
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GC35953
E3 ligase Ligand-Linker Conjugates 46
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GC35954
E3 ligase Ligand-Linker Conjugates 47
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GC35955
E3 ligase Ligand-Linker Conjugates 48
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GC35956
E3 ligase Ligand-Linker Conjugates 49
Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49
E3 ligase Ligand-Linker Conjugates 49 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. -
GC32813
E3 ligase Ligand-Linker Conjugates 5
E3 ligase Ligand-Linker Conjugates 5 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
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GC33113
E3 ligase Ligand-Linker Conjugates 5 Free Base
VH032-PEG3-NH2; VHL Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 5 Free Base
E3 ligase Ligand-Linker Conjugates 5 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. -
GC35957
E3 ligase Ligand-Linker Conjugates 50
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GC35958
E3 ligase Ligand-Linker Conjugates 51
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GC32839
E3 ligase Ligand-Linker Conjugates 6
E3 ligase Ligand-Linker Conjugates 6 (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
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GC33111
E3 ligase Ligand-Linker Conjugates 6 Free Base
VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base
E3 ligase Ligand-Linker Conjugates 6 Free Base (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs. -
GC32866
E3 ligase Ligand-Linker Conjugates 7
E3 Ligase Ligand-Linker Conjugate 7
E3 ligase Ligand-Linker Conjugates 7 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. -
GC32994
E3 ligase Ligand-Linker Conjugates 7 Free Base
VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base
E3 ligase Ligand-Linker Conjugates 7 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. -
GC62126
Glutarimide-Isoindolinone-NH-PEG2-COOH
Glutarimide-Isoindolinone-NH-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.
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GC62991
Glutarimide-Isoindolinone-NH-PEG3-COOH
Glutarimide-Isoindolinone-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.
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GC62232
Glutarimide-Isoindolinone-NH-PEG4-COOH
Glutarimide-Isoindolinone-NH-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates a cereblon ligand and a linker used in PROTAC technology.
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GC63474
Lenalidomide-C5-amido-Boc
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC.
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GC64104
Lenalidomide-C5-NH2 TFA
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.
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GC64867
Lenalidomide-PEG1-azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2.
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GC38808
Lenalidomide-propargyl-C2-NH2 hydrochloride
Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224.
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GC62154
N-Descyclopropanecarbaldehyde Olaparib
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor.
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GC68431
NJH-2-030
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GC67991
Nutlin-C1-amido-PEG4-C2-N3
MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48
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GC63149
Pom-8PEG
Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader.
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GC62131
Pomalidomide 4’-PEG2-azide
Pomalidomide 4’-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC50692
Pomalidomide 4'-alkylC8-amine
Pomalidomide 4'-alkylC8-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC50666
Pomalidomide 4'-PEG1-amine
Pomalidomide 4'-PEG1-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC50545
Pomalidomide 4'-PEG3-acid
Pomalidomide 4'-PEG3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
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GC50693
Pomalidomide 4'-PEG3-amine
Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. -
GC50713
Pomalidomide 4'-PEG5-acid
Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology.
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GC69726
Pomalidomide-5'-PEG8-C2-COOH
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate composed of Pomalidomide and a linker. It can be used to synthesize PROTACs.
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GC39171
Pomalidomide-amido-C1-Br
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1. PROTAC B-Raf degrader 1 has anti-cancer activity.
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GC61449
Pomalidomide-amido-C3-COOH
Pomalidomide-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC68156
Pomalidomide-amino-PEG3-NH2 hydrochloride
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GC63811
Pomalidomide-amino-PEG4-NH2 hydrochloride
Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC68157
Pomalidomide-amino-PEG5-NH2 hydrochloride
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GC65092
Pomalidomide-C12-NH2 hydrochloride
Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader.
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GC38381
Pomalidomide-C2-NH2 hydrochloride
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
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GC61199
Pomalidomide-C7-COOH
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders.
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GC64769
Pomalidomide-PEG1-azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1.
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GC69727
Pomalidomide-PEG1-NH2 hydrochloride
Pomalidomide-PEG1-NH2 hydrochloride is a crosslinking E3 ligase ligand conjugate composed of the E3 ligase ligand pomalidomide and a PEGylated crosslinker with an end amine group, which is used to react with carboxylic acid groups on the target ligand.
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GC61617
Pomalidomide-PEG2-azide
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
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GC61618
Pomalidomide-PEG3-azide
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.