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Home >> Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Targets for  E3 Ligase Ligand-Linker Conjugate

Products for  E3 Ligase Ligand-Linker Conjugate

  1. Cat.No. Product Name Information
  2. GC61618 Pomalidomide-PEG3-azide Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide-PEG3-azide Chemical Structure
  3. GC61201 Pomalidomide-PEG3-C2-NH2 TFA Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Pomalidomide-PEG3-C2-NH2 TFA Chemical Structure
  4. GC61202 Pomalidomide-PEG4-azide Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-PEG4-azide Chemical Structure
  5. GC65196 Pomalidomide-PEG6-butyl iodide Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology. Pomalidomide-PEG6-butyl iodide Chemical Structure
  6. GC50657 Thalidomide 4'-ether-alkylC2-acid Thalidomide 4'-ether-alkylC2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC2-acid Chemical Structure
  7. GC50583 Thalidomide 4'-ether-alkylC2-amine Thalidomide 4'-ether-alkylC2-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC2-amine Chemical Structure
  8. GC50663 Thalidomide 4'-ether-alkylC3-acid Thalidomide 4'-ether-alkylC3-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC3-acid Chemical Structure
  9. GC50673 Thalidomide 4'-ether-alkylC4-acid Thalidomide 4'-ether-alkylC4-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC4-acid Chemical Structure
  10. GC50683 Thalidomide 4'-ether-alkylC5-acid Thalidomide 4'-ether-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC5-acid Chemical Structure
  11. GC50688 Thalidomide 4'-ether-alkylC6-acid Thalidomide 4'-ether-alkylC6-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC6-acid Chemical Structure
  12. GC50528 Thalidomide 4'-ether-alkylC6-amine Thalidomide 4'-ether-alkylC6-amine is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET. Thalidomide 4'-ether-alkylC6-amine Chemical Structure
  13. GC50691 Thalidomide 4'-ether-alkylC7-acid Thalidomide 4'-ether-alkylC7-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide 4'-ether-alkylC7-acid Chemical Structure
  14. GC50622 Thalidomide 4'-ether-PEG5-amine Cereblon ligand with PEG linker and terminal amine for onward chemistry Thalidomide 4'-ether-PEG5-amine Chemical Structure
  15. GC50620 Thalidomide 4'-oxyacetamide-alkylC2-amine Thalidomide 4'-oxyacetamide-alkylC2-amine incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4'-oxyacetamide-alkylC2-amine can be used to design the PROTACs. Thalidomide 4'-oxyacetamide-alkylC2-amine Chemical Structure
  16. GC50626 Thalidomide 4'-oxyacetamide-PEG1-amine Thalidomide 4'-oxyacetamide-PEG1-amine, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. Thalidomide 4'-oxyacetamide-PEG1-amine Chemical Structure
  17. GC50463 Thalidomide 4'-oxyacetamide-PEG4-amine Thalidomide 4'-oxyacetamide-PEG4-amine, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. Thalidomide 4'-oxyacetamide-PEG4-amine Chemical Structure
  18. GC63831 Thalidomide-4-O-C10-COOH Thalidomide-4-O-C10-COOH is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs. Thalidomide-4-O-C10-COOH Chemical Structure
  19. GC70023 Thalidomide-5-PEG4-NH2 hydrochloride

    Thalidomide-5-PEG4-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate, containing a cereblon ligand based on Thalidomide and one linker.

     Thalidomide-5-PEG4-NH2 hydrochloride Chemical Structure
  20. GC67530 Thalidomide-NH-C10-COOH Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based von Hippel-Lindau (VHL) ligand and a linker used in PROTAC technology. Thalidomide-NH-C10-COOH Chemical Structure
  21. GC67504 Thalidomide-NH-C2-PEG3-OH Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739. Thalidomide-NH-C2-PEG3-OH Chemical Structure
  22. GC62722 Thalidomide-NH-C4-NH-Boc Thalidomide-NH-C4-NH-Boc (compound 15) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-NH-C4-NH-Boc Chemical Structure
  23. GC67508 Thalidomide-NH-C4-NH2 TFA Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 . PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader. Thalidomide-NH-C4-NH2 TFA Chemical Structure
  24. GC67327 Thalidomide-NH-C6-NH2 Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-NH-C6-NH2 Chemical Structure
  25. GC39513 Thalidomide-NH-C6-NH2 TFA Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-NH-C6-NH2 TFA Chemical Structure
  26. GC38949 Thalidomide-NH-PEG2-C2-NH2 TFA

    Thalidomide-NH-PEG2-C2-NH2 TFA

     Thalidomide-NH-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Thalidomide-NH-PEG2-C2-NH2 TFA Chemical Structure
  27. GC62681 Thalidomide-NH-PEG3-COOH Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-NH-PEG3-COOH Chemical Structure
  28. GC62204 Thalidomide-NH-PEG4-COOH Thalidomide-NH-PEG4-COOH is an E3 ligase ligand-linker conjugate which can be used for synthesizing dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP. Thalidomide-NH-PEG4-COOH Chemical Structure
  29. GC67505 Thalidomide-NH-PEG4-Ms Thalidomide-NH-PEG4-Ms is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739. Thalidomide-NH-PEG4-Ms Chemical Structure
  30. GC67506 Thalidomide-NH-PEG8-Ts Thalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader . Thalidomide-NH-PEG8-Ts Chemical Structure
  31. GC61329 Thalidomide-O-amido-C3-COOH

    Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15

     Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C3-COOH Chemical Structure
  32. GC38095 Thalidomide-O-amido-C3-NH2 (TFA)

    Cereblon Ligand-Linker Conjugates 16 TFA; E3 Ligase Ligand-Linker Conjugates 52 TFA

     Thalidomide-O-amido-C3-NH2 (TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C3-NH2 (TFA) Chemical Structure
  33. GC62595 Thalidomide-O-amido-C3-PEG3-C1-NH2 Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Thalidomide-O-amido-C3-PEG3-C1-NH2 Chemical Structure
  34. GC67499 Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs. Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Structure
  35. GC68155 Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc Chemical Structure
  36. GC67606 Thalidomide-O-amido-PEG-C2-NH2 Thalidomide-O-amido-PEG-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-PEG-C2-NH2 Chemical Structure
  37. GC61330 Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

    Cereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23

     Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 Chemical Structure
  38. GC33847 Thalidomide-O-amido-PEG2-C2-NH2 TFA

    Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA

     Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Thalidomide-O-amido-PEG2-C2-NH2 TFA Chemical Structure
  39. GC70024 Thalidomide-O-C6-azide

    Thalidomide-O-C6-azide is an E3 ligase ligand-linker conjugate, which includes a cereblon ligand based on Thalidomide and one linker.

     Thalidomide-O-C6-azide Chemical Structure
  40. GC67478 Thalidomide-O-C6-NH2 Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-C6-NH2 Chemical Structure
  41. GC66314 Thalidomide-O-C6-NH2 TFA Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13 (HY-114421), a degrader of FKBP12F36V and BET. Thalidomide-O-C6-NH2 TFA Chemical Structure
  42. GC67827 Thalidomide-O-C6-NHBoc Thalidomide-O-C6-NHBoc Chemical Structure
  43. GC38861 Thalidomide-O-PEG2-propargyl

    E3 ligase Ligand-Linker Conjugates 32

     Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Thalidomide-O-PEG2-propargyl Chemical Structure
  44. GC66637 Thalidomide-O-PEG4-amine Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-amine Chemical Structure
  45. GC64790 Thalidomide-O-PEG4-amine hydrochloride Thalidomide-O-PEG4-amine hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-amine hydrochloride Chemical Structure
  46. GC63219 Thalidomide-O-PEG4-amine TFA Thalidomide-O-PEG4-amine TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-amine TFA Chemical Structure
  47. GC66642 Thalidomide-O-PEG4-azide Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide Chemical Structure
  48. GC66635 Thalidomide-O-PEG4-Boc Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-Boc Chemical Structure
  49. GC63529 Thalidomide-O-PEG4-NHS ester Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Thalidomide-O-PEG4-NHS ester Chemical Structure
  50. GC66644 Thalidomide-PEG2-C2-NH2

    Thalidomide-NH-PEG2-C2-NH2

     Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Thalidomide-PEG2-C2-NH2 Chemical Structure
  51. GC67741 Thalidomide-PEG2-NH2 hydrochloride Thalidomide-PEG2-NH2 hydrochloride Chemical Structure
  52. GC62176 Thalidomide-PEG3-COOH Thalidomide-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-PEG3-COOH Chemical Structure
  53. GC62177 Thalidomide-PEG4-COOH Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-PEG4-COOH Chemical Structure
  54. GC67507 Thalidomide-PEG4-NH2 hydrochloride Thalidomide-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-PEG4-NH2 hydrochloride Chemical Structure
  55. GC62226 Thalidomide-PEG5-COOH Thalidomide-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-PEG5-COOH Chemical Structure
  56. GC67740 Thalidomide-PEG5-NH2 hydrochloride Thalidomide-PEG5-NH2 hydrochloride Chemical Structure
  57. GC63220 Thalidomide-piperazine-Boc Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC. Thalidomide-piperazine-Boc Chemical Structure
  58. GC63221 Thalidomide-Piperazine-PEG1-NH2 diTFA Thalidomide-Piperazine-PEG1-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-PEG1-NH2 diTFA Chemical Structure
  59. GC63222 Thalidomide-Piperazine-PEG2-NH2 diTFA Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-PEG2-NH2 diTFA Chemical Structure
  60. GC63223 Thalidomide-Piperazine-PEG3-COOH Thalidomide-Piperazine-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-PEG3-COOH Chemical Structure
  61. GC63224 Thalidomide-Piperazine-PEG3-NH2 Thalidomide-Piperazine-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-PEG3-NH2 Chemical Structure
  62. GC63225 Thalidomide-Piperazine-Piperidine Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-Piperidine Chemical Structure
  63. GC64640 Thalidomide-Piperazine-Piperidine hydrochloride Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Piperazine-Piperidine hydrochloride Chemical Structure
  64. GC62718 Thalidomide-Propargyne-PEG1-COOH Thalidomide-Propargyne-PEG1-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Propargyne-PEG1-COOH Chemical Structure
  65. GC62713 Thalidomide-Propargyne-PEG2-COOH Thalidomide-Propargyne-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Propargyne-PEG2-COOH Chemical Structure
  66. GC62714 Thalidomide-Propargyne-PEG3-COOH Thalidomide-Propargyne-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-Propargyne-PEG3-COOH Chemical Structure
  67. GC50592 VH 032 amide-alkylC10-amine

    VH032-C10-NH2 dihydrochloride

     VH 032 amide-alkylC10-amine (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC. VH 032 amide-alkylC10-amine Chemical Structure
  68. GC50584 VH 032 amide-alkylC2-amine VH 032 amide-alkylC2-amine incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs. VH 032 amide-alkylC2-amine Chemical Structure
  69. GC50585 VH 032 amide-alkylC6-amine

    VH032-C6-NH2 dihydrochloride

     VH 032 amide-alkylC6-amine (VH032-C6-NH2 dihydrochloride) is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the VH032 based VHL ligand and a linker used forAKTPROTAC degrader. VH 032 amide-alkylC6-amine Chemical Structure
  70. GC38870 VH032-PEG3-acetylene VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. VH032-PEG3-acetylene Chemical Structure
  71. GC67980 VH285-PEG4-C4-Cl

    HaloPROTAC 3

     VH285-PEG4-C4-Cl Chemical Structure

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