SNIPER

Specific and Non-genetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers (SNIPER) is designed to induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins. SNIPER and PROTAC are hybrid molecules composed of two different ligands connected by a linker; one ligand is for a target protein and the other is for E3 ubiquitin ligases. A series of SNIPER(ABL) compounds are synthesized by combination of various inhibitors (e.g. ABL, BRD, AR, ER) and IAP ligands, and the linker is optimized for protein knockdown activity.

Targets for SNIPER

Products for SNIPER

Cat.No. Product Name Information
GC35522 Biotin-BS Biotin-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase.
GC36981 PROTAC AR Degrader-4
GC61481 PROTAC AR Degrader-4 TFA
GC34730 PROTAC CRABP-II Degrader-1 PROTAC CRABP-II Degrader-1 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on IAP ligand.
GC34731 PROTAC CRABP-II Degrader-2 PROTAC CRABP-II Degrader-2 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on IAP ligand.
GC34732 PROTAC CRABP-II Degrader-3 PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on IAP ligand.
GC34735 PROTAC ERα Degrader-2
GC34740 PROTAC RAR Degrader-1 PROTAC RAR Degrader-1 comprises a IAP ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs).
GC37657 SNIPER(ER)-110 SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.