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TL 12-186

Catalog No.GC50484

Multikinase degrading PROTAC

Products are for research use only. Not for human use. We do not sell to patients.

TL 12-186 Chemical Structure

Cas No.: 2250025-88-6

Size Price Stock Qty
5 mg
$354.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

PROTAC® comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide . Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 is also available. PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID:29129717

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Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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