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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase

Products for  Tyrosine Kinase

  1. Cat.No. Product Name Information
  2. GC31701 RK-24466 (KIN 001-51)

    Lymphocyte-specific Protein Tyrosine Kinase, RK-24466

     RK-24466 (KIN 001-51) (KIN 001-51) is a potent and selective Lck inhibitor; inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively. RK-24466 (KIN 001-51) Chemical Structure
  3. GC17622 Ro 08-2750

    antagonist of nerve growth factor (NGF)

     Ro 08-2750 Chemical Structure
  4. GC15466 RO9021 Syk inhibitor RO9021 Chemical Structure
  5. GC69825 Robatumumab

    Sch 717454; 19D12

    Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor 1 receptor) antibody. Robatumumab has anti-tumor activity and anti-cancer cell proliferation activity. Robatumumab can be used for research on osteosarcoma and Ewing's sarcoma.

     Robatumumab Chemical Structure
  6. GC19154 Roblitinib

    Roblitinib

     Roblitinib (FGF-401) is a 1,8-naphthyridine pyridine derivative. Roblitinib Chemical Structure
  7. GC33061 Rociletinib hydrobromide (CO-1686 (hydrobromide)) Rociletinib hydrobromide (CO-1686 (hydrobromide)) (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Rociletinib hydrobromide (CO-1686 (hydrobromide)) Chemical Structure
  8. GC34067 Rogaratinib (BAY1163877) Rogaratinib (BAY1163877) (BAY1163877) is a potent and selective fibroblast growth factor receptor (FGFR) inhibitor. Rogaratinib (BAY1163877) Chemical Structure
  9. GC37556 ROR agonist-1 ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5. ROR agonist-1 Chemical Structure
  10. GC69830 RORγt agonist 3

    RORγt agonist 2 is an effective RORγt activator. It promotes Th17 cell differentiation, increases pro-inflammatory cytokine levels, and enhances lymphocyte cytotoxicity. RORγt agonist 2 inhibits the production of regulatory T cells, thereby suppressing immune responses (extracted from patent WO2021136326A1, compound 23).

     RORγt agonist 3 Chemical Structure
  11. GC68411 RORγt Inverse agonist 10 RORγt Inverse agonist 10 Chemical Structure
  12. GC62349 RORγt inverse agonist 13 RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM. RORγt inverse agonist 13 Chemical Structure
  13. GC65953 RORγt inverse agonist 23 RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist. RORγt inverse agonist 23 Chemical Structure
  14. GC37557 RORγt Inverse agonist 3 RORγt Inverse agonist 3 Chemical Structure
  15. GC62623 RORγt Inverse agonist 6 RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 Chemical Structure
  16. GC10517 Rp-8-bromo-Cyclic GMPS (sodium salt)

    Rp-8-bromo-cGMPS

     cGMP-dependent protein kinase (cGK) inhibitor Rp-8-bromo-Cyclic GMPS (sodium salt) Chemical Structure
  17. GC10706 Rp-8-pCPT-Cyclic GMPS (sodium salt)

    Rp-8-pCPT-cGMPS

     GMP-dependent protein kinases (cGKs) inhibitor Rp-8-pCPT-Cyclic GMPS (sodium salt) Chemical Structure
  18. GC14779 RR-src Tyrosine kinase substrate peptide RR-src Chemical Structure
  19. GC37568 RTC-5

    TRC-382

     RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling. RTC-5 Chemical Structure
  20. GC38580 RU-301 RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 Chemical Structure
  21. GC64385 RU-302 RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth. RU-302 Chemical Structure
  22. GC69843 Ruserontinib

    SKLB1028

    Ruserontinib (SKLB1028) is an orally active inhibitor of EGFR, FLT3, and Abl kinases with an IC50 value of 55 nM against human FLT3. It has anti-tumor activity.

     Ruserontinib Chemical Structure
  23. GC63332 S116836 S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies. S116836 Chemical Structure
  24. GC65155 S18-000003 S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays. S18-000003 Chemical Structure
  25. GC19317 S49076 S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 values below 20 nM. S49076 Chemical Structure
  26. GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells. S961 Chemical Structure
  27. GC61550 S961 acetate S961 acetate is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively. S961 acetate Chemical Structure
  28. GC39189 S961 TFA S961 TFA is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively. S961 TFA Chemical Structure
  29. GC41626 Sappanone A Sappanone A is a homoisoflavanone with strong antioxidant and anti-inflammatory activities. Sappanone A Chemical Structure
  30. GC33189 SAR125844 SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays. SAR125844 Chemical Structure
  31. GC12586 SAR131675

    VEGFR3 inhibitor,selective and ATP-competitve

     SAR131675 Chemical Structure
  32. GC15197 Saracatinib (AZD0530)

    AZD 0530

     Saracatinib (AZD0530) (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib (AZD0530) shows high selectivity over other tyrosine kinases. Saracatinib (AZD0530) Chemical Structure
  33. GC19321 Savolitinib

    AZD6094, HMPL-504, Volitinib

     Savolitinib (AZD6094) ia highly potent and selective c-Met inhibitor with an IC50 of 5 nM. Savolitinib Chemical Structure
  34. GC48070 SB-431542 (hydrate) Inhibitor of receptors ALK4, ALK5, and ALK7 SB-431542 (hydrate) Chemical Structure
  35. GC12064 SB1317

    TG02, Zotiraciclib

     A multi-kinase inhibitor SB1317 Chemical Structure
  36. GC14349 SB525334

    TGF-β RI Kinase Inhibitor VIII

     (TGF-beta1) receptor inhibitor SB525334 Chemical Structure
  37. GC19108 SCR-1481B1 SCR-1481B1 (c-Met inhibitor 2) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor. SCR-1481B1 Chemical Structure
  38. GN10633 Scutellarein

    6-Hydroxyapigenin

     Scutellarein Chemical Structure
  39. GC37620 Secretin, canine Secretin, canine is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Secretin, canine Chemical Structure
  40. GC68430 Selatinib Selatinib Chemical Structure
  41. GC32808 Selitrectinib (LOXO-195)

    Selitrectinib

     Selitrectinib (LOXO-195) (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively. Selitrectinib (LOXO-195) Chemical Structure
  42. GC33192 Selpercatinib A RET kinase inhibitor Selpercatinib Chemical Structure
  43. GN10603 Sennoside B Sennoside B Chemical Structure
  44. GC62114 Seralutinib

    GB002; PK10571

     Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib Chemical Structure
  45. GC19330 SGI-7079 SGI-7079 is an Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 uM, respectively. SGI-7079 Chemical Structure
  46. GC15664 SGX-523 MET inibitor, highly selective, ATP-competitive SGX-523 Chemical Structure
  47. GC49713 SIKVAV (acetate)

    Hexapeptide-10, Ser-Ile-Lys-Val-Ala-Val

     A laminin α1-derived peptide SIKVAV (acetate) Chemical Structure
  48. GC11455 Silvestrol Silvestrol Chemical Structure
  49. GC62385 Simotinib Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities. Simotinib Chemical Structure
  50. GC19332 Sitravatinib

    MGCD-516

     Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/L. Sitravatinib Chemical Structure
  51. GC13738 SKLB1002 VEGFR2 inhibitor,potent and ATP-competitve SKLB1002 Chemical Structure
  52. GC33141 SKLB4771 (FLT3-IN-1)

    FLT3-?IN-?1

     SKLB4771 (FLT3-IN-1) is a potent and selective Flt3 inhibitor with an IC50 value of 10 nM. SKLB4771 (FLT3-IN-1) downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue. SKLB4771 (FLT3-IN-1) Chemical Structure
  53. GC12776 SKLB610

    SKLB610; SKLB 610; SKLB-610

     An inhibitor of VEGFR2 SKLB610 Chemical Structure
  54. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71 Chemical Structure
  55. GC44903 SMAD3 Inhibitor, SIS3 SMAD3 Inhibitor, SIS3 is a potent and selective inhibitor of Smad3 phosphorylation. SMAD3 Inhibitor, SIS3 Chemical Structure
  56. GC65592 SNIPER(ABL)-020 SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein. SNIPER(ABL)-020 Chemical Structure
  57. GC17369 Sorafenib

    BAY 43-9006

    Sorafenib acts as a multi-kinase inhibitor, targeting Raf-1 and B-Raf with IC50 values of 6 nM and 22 nM, respectively.

     Sorafenib Chemical Structure
  58. GC37664 Sorafenib (D3)

    BAY 43-9006-d3

     An internal standard for the quantification of sorafenib Sorafenib (D3) Chemical Structure
  59. GC37665 Sorafenib (D4)

    Bay 43-9006-d4

     Sorafenib (D4) (Bay 43-9006-d4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Sorafenib (D4) Chemical Structure
  60. GC69931 Sotuletinib hydrochloride

    BLZ945 hydrochloride

    Sotuletinib (BLZ945) is an effective, selective, and brain-penetrant inhibitor of CSF-1R (c-Fms), with an IC50 of 1 nM and a selectivity that is 1000 times greater than other receptor tyrosine kinases.

     Sotuletinib hydrochloride Chemical Structure
  61. GC64279 Sovleplenib

    HMPL-523

     Sovleplenib (HMPL-523) is a highly potent, orally available and selective SYK inhibitor with an IC50 of 25 nM. Anti-tumor activity. Sovleplenib can be used for the research of immune thrombocytopenia (ITP). Sovleplenib Chemical Structure
  62. GC34809 SPP-86 SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells. SPP-86 Chemical Structure
  63. GC50430 Squarunkin A hydrochloride UNC119 chaperone-cargo interaction inhibitor; disrupts Src activation Squarunkin A hydrochloride Chemical Structure
  64. GC14054 SR 0987 agonist of the T cell-specific isoform of RORγ SR 0987 Chemical Structure
  65. GC15009 SR 1001 RORα and γ inverse agonist SR 1001 Chemical Structure
  66. GC14418 SR 1555 (hydrochloride) inverse agonist of RORγ SR 1555 (hydrochloride) Chemical Structure
  67. GC14284 SR 2211 inverse agonist of RORγ, potent and selective SR 2211 Chemical Structure
  68. GC16392 SR1078

    SR 1078;SR-1078

     A selective RORα/RORγ agonist SR1078 Chemical Structure
  69. GC12877 SR3335

    ML 176

     A selective inverse agonist of RORα SR3335 Chemical Structure
  70. GC16957 Src I1 Src I1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Src I1 Chemical Structure
  71. GC34811 SRI 31215 TFA SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer. SRI 31215 TFA Chemical Structure
  72. GC45831 SRI-011381 A TGF-β signaling activator SRI-011381 Chemical Structure
  73. GC62456 SRX3207 SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression. SRX3207 Chemical Structure
  74. GC10491 SSR128129E

    SSR

     allosteric inhibitor of FGFR1, orally-active SSR128129E Chemical Structure
  75. GC37679 SSR128129E free acid

    SSR free acid

     SSR128129E free acid is an orally available and allosteric FGFR inhibitor with an IC50 of 1.9 μM for FGFR1. SSR128129E free acid Chemical Structure
  76. GC15299 Staurosporine(CGP 41251)

    Stsp

     Staurosporin, a small kinase inhibitor, is an alkaloid derived from the bacterium Streptomyces staurosporeus. Staurosporine(CGP 41251) Chemical Structure
  77. GC12686 SU 16f

    SU16F

     PDGFRβ inhibitor SU 16f Chemical Structure
  78. GC11417 SU 4312

    NSC 86429

     VEGFR and PDGFR tyrosine kinases inhibitor SU 4312 Chemical Structure
  79. GC48800 SU 4942 A modulator of tyrosine kinase signaling SU 4942 Chemical Structure
  80. GC44958 SU 5205 SU 5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK1; IC50 = 9.6 μM). SU 5205 Chemical Structure
  81. GC40755 SU 5214

    SU4949

     SU 5214 is a 3-heteroaryl-2-indoline that was designed in a drug discovery program for development of tyrosine kinase inhibitors. SU 5214 Chemical Structure
  82. GC14660 SU 5402 An inhibitor of VEGFR2, FGFR1, and PDGFRβ SU 5402 Chemical Structure
  83. GC11089 SU11274

    Met Kinase Inhibitor

     C-Met inhibitor,potent and selective SU11274 Chemical Structure
  84. GC14733 SU14813

    SU-14813;SU 14813

     A dual VEGFR and PDGFR family kinase inhibitor SU14813 Chemical Structure
  85. GC11790 SU14813 double bond Z

    SU-14813;SU 14813

     Tyrosine kinase inhibitor SU14813 double bond Z Chemical Structure
  86. GC14315 SU14813 maleate A dual VEGFR and PDGFR family kinase inhibitor SU14813 maleate Chemical Structure
  87. GC33840 SU1498 (AG 1498)

    AG-1498, Tyrphostin SU 1498

     SU1498 (AG 1498) (AG 1498) is a selective inhibitor of the VEGFR2; inhibits Flk-1 with an IC50 of value of 700 nM. SU1498 (AG 1498) Chemical Structure
  88. GC38034 SU16f A potent inhibitor of PDGFRβ SU16f Chemical Structure
  89. GC61957 SU4984 SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer. SU4984 Chemical Structure
  90. GC61780 SU5204 SU5204, a tyrosine kinase inhibitor, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively. SU5204 Chemical Structure
  91. GC25969 SU5208

    3-[(Thien-2-yl)methylene]-2-indolinone

     SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2). SU5208 Chemical Structure
  92. GC32469 SU5408 (VEGFR2 Kinase Inhibitor I)

    SU 5408

     SU5408 (VEGFR2 Kinase Inhibitor I) (VEGFR2 Kinase Inhibitor I) is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70 nM. SU5408 (VEGFR2 Kinase Inhibitor I) Chemical Structure
  93. GC15307 SU5416

    NSC 696819, Semaxinib, Sugen 5416, VEGFR 2 Kinase Inhibitor

     SU5416 is a potent small molecule vascular endothelial growth factor receptor (VEGFR) inhibitor. SU5416 Chemical Structure
  94. GC14582 SU5614 SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 Chemical Structure
  95. GC17500 SU6656 Src tyrosine kinases inhibitor SU6656 Chemical Structure
  96. GC44966 Sucrose octasulfate (potassium salt)

    SOS, Sucrosofate potassium

     Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. Sucrose octasulfate (potassium salt) Chemical Structure
  97. GC32805 Sulfatinib (HMPL-012)

    HMPL-012

     Sulfatinib (HMPL-012) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM. Sulfatinib (HMPL-012) Chemical Structure
  98. GC19341 SUN11602 SUN11602 is a novel aniline compound with basic fibroblast growth factor-like activity. SUN11602 Chemical Structure
  99. GC17651 Sunitinib RTK inhibitor Sunitinib Chemical Structure
  100. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib Sunitinib-d10 Chemical Structure
  101. GC63521 Sunvozertinib

    DZD9008

     Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52). Sunvozertinib Chemical Structure

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