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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase

Products for  Tyrosine Kinase

  1. Cat.No. Product Name Information
  2. GC17473 Pelitinib (EKB-569)

    EKB569

     Pelitinib (EKB-569) (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. Pelitinib (EKB-569) Chemical Structure
  3. GC32915 Pemigatinib

    INCB054828

     An FGFR inhibitor Pemigatinib Chemical Structure
  4. GC60283 Pentagamavunon-1

    PGV-1

     Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation. Pentagamavunon-1 Chemical Structure
  5. GC47938 Pericosine A

    (+)-Pericosine A

     A fungal metabolite with anticancer activity Pericosine A Chemical Structure
  6. GC34210 Pertuzumab (Anti-Human HER2, Humanized Antibody) Pertuzumab (Anti-Human HER2, Humanized Antibody), the first of a new class of agents designated as HER dimerisation inhibitors, is a humanised IgG1 monoclonal antibody (mAb) that sterically binds domain II of the erbB2 receptor. Pertuzumab (Anti-Human HER2, Humanized Antibody) Chemical Structure
  7. GC69690 Petosemtamab

    MCLA 158

    Petosemtamab (MCLA 158) is a monoclonal antibody (mAb) that targets both EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab blocks EGFR signaling and receptor degradation in LGR5+ cancer cells. It can be used for research on solid tumors such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC), etc.

     Petosemtamab Chemical Structure
  8. GC44605 Petunidin (chloride)

    Petunidol

    Petunidin is an O-methylated anthocyanidin derived from delphinidin that imparts blue-red pigments to flowers, fruits, and red wine.

     Petunidin (chloride) Chemical Structure
  9. GC12222 Pexidartinib (PLX3397)

    PLX3397

     Pexidartinib (PLX3397) (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX3397) (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX3397) (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib (PLX3397) Chemical Structure
  10. GC34708 Pexidartinib hydrochloride Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity. Pexidartinib hydrochloride Chemical Structure
  11. GC50346 PF 06273340 Potent and selective pan-Trk inhibitor; peripherally restricted PF 06273340 Chemical Structure
  12. GC17630 PF 06465469 inhibitor of interleukin-2 inducible T cell kinase (ITK) and Bruton's tyrosine kinase (BTK) PF 06465469 Chemical Structure
  13. GC14767 PF-00562271

    PF-562271;PF00562271;PF62271

     PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively. PF-00562271 Chemical Structure
  14. GC18074 PF-03814735 PF-03814735 is a potent, orally bioavailable, reversible inhibitor of both Aurora1 and Aurora2 kinases with IC50 values of 0.8nM and 5nM, respectively [1]. PF-03814735 Chemical Structure
  15. GC12729 PF-04217903 C-Met inhibitor,selective and ATP-competitive PF-04217903 Chemical Structure
  16. GC15733 PF-04217903 methanesulfonate

    PF04217903 mesylate

     A c-Met inhibitor PF-04217903 methanesulfonate Chemical Structure
  17. GC31495 PF-05231023

    Mal-PEG2-AZD

     PF-05231023 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PF-05231023 Chemical Structure
  18. GC13850 PF-06447475 LRRK2 inhibitor PF-06447475 Chemical Structure
  19. GC64566 PF-06454589 PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06454589 Chemical Structure
  20. GC64506 PF-06456384 trihydrochloride PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06456384 trihydrochloride Chemical Structure
  21. GC32927 PF-06459988 PF-06459988 is an orally activity, irreversible and mutant-selective inhibitor of EGFR mutant forms. PF-06459988 demonstrates high potency and specificity to the T790M-containing double mutant EGFRs. PF-06459988 can be used for the research of cancer. PF-06459988 Chemical Structure
  22. GC14794 PF-06463922

    Lorlatinib

     PF-06463922 (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. PF-06463922 has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. PF-06463922 has anticancer activity. PF-06463922 Chemical Structure
  23. GC34710 PF-06747711 PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. PF-06747711 Chemical Structure
  24. GC14407 PF-431396 Pyk2 and FAK inhibitor PF-431396 Chemical Structure
  25. GC61852 PF-4618433 PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 Chemical Structure
  26. GC15380 PF-562271

    PF562271;PF 562271

     ATP-competitive FAK inhibitor, reversible PF-562271 Chemical Structure
  27. GC10810 PF-562271 HCl

    PF562271 HCl;PF 562271 HCl

     PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively. PF-562271 HCl Chemical Structure
  28. GC11107 PF-573228

    FAK Inhibitor II, Focal Adhesion Kinase Inhibitor II

     ATP-competitive FAK inhibitor PF-573228 Chemical Structure
  29. GC44613 PF-6274484 PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively). PF-6274484 Chemical Structure
  30. GC65009 PF-6683324

    Trk-IN-4

     PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays withIC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. PF-6683324 Chemical Structure
  31. GC19287 PF06650833

    PF-06650833

     PF06650833 (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. PF06650833 Chemical Structure
  32. GC36888 PFE-360

    PF-06685360

     PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo. PFE-360 Chemical Structure
  33. GC11733 PHA-665752 C-Met inhibitor,potent and ATP-competitive PHA-665752 Chemical Structure
  34. GN10503 Piceatannol

    Astringenin, transPicetannol, trans3,3',4,5'Tetrahydroxystilbene

     Piceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a naturally occurring hydroxylated analogue of resveratrol. Piceatannol Chemical Structure
  35. GC50083 PKI 166 hydrochloride Potent EGFR-kinase inhibitor PKI 166 hydrochloride Chemical Structure
  36. GC40915 PKI-166 An inhibitor of EGFR PKI-166 Chemical Structure
  37. GC17925 PKR Inhibitor

    C16,GW 506033X,Protein Kinase RNA-activated

     PKR Inhibitor (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR Inhibitor Chemical Structure
  38. GC36940 PLX5622 A CSF1R inhibitor PLX5622 Chemical Structure
  39. GC38836 PLX5622 hemifumarate PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 ?M; Ki=5.9 nM). PLX5622 hemifumarate Chemical Structure
  40. GC15075 PLX647 dual inhibitor of FMS and KIT kinases PLX647 Chemical Structure
  41. GC15164 PND-1186

    SR 2516, VS-4718

     A potent FAK inhibitor PND-1186 Chemical Structure
  42. GC62111 PND-1186 hydrochloride

    VS-4718 hydrochloride; SR-2516 hydrochloride

     PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis. PND-1186 hydrochloride Chemical Structure
  43. GC14396 Ponatinib (AP24534)

    AP 24534

     Ponatinib (AP24534) (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. Ponatinib (AP24534) Chemical Structure
  44. GC52104 Ponatinib (hydrochloride)

    AP 24534

     An inhibitor of native and mutant Bcr-Abl Ponatinib (hydrochloride) Chemical Structure
  45. GC45828 Ponatinib-d8 An internal standard for the quantification of ponatinib Ponatinib-d8 Chemical Structure
  46. GC69728 Ponezumab

    PF-04360365; RN 1219

    Ponezumab (PF-04360365) is a humanized monoclonal antibody against amyloid beta protein of the IgG2 class. Ponezumab can reduce Aβ levels in the central nervous system and improve performance in various learning and memory models in mice. Ponezumab can be used for research on Alzheimer's disease.

     Ponezumab Chemical Structure
  47. GC17916 Poziotinib

    HM781-36B

     A irreversible pan-HER inhibitor Poziotinib Chemical Structure
  48. GC17990 PP 1

    AGL 1872; EI 275

     Potent, selective Src family tyrosine kinase inhibitor PP 1 Chemical Structure
  49. GC10344 PP 2 (AG 1879)

    AGL 1879

     A selective inhibitor of Src tyrosine kinases PP 2 (AG 1879) Chemical Structure
  50. GC13797 PP 3

    NSC 1401

     Negative control for the Src kinase inhibitor PP 2 PP 3 Chemical Structure
  51. GC11003 PP121 Dual inhibitor of tyrosine and phosphoinositide kinases PP121 Chemical Structure
  52. GC32835 PP58 PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values. PP58 Chemical Structure
  53. GC17137 pp60 c-src (521-533) (phosphorylated) Peptide corresponding to the pp60c-src carboxy terminal regulatory domain pp60 c-src (521-533) (phosphorylated) Chemical Structure
  54. GC12779 PPY A Abl kinases inhibitor PPY A Chemical Structure
  55. GC16991 PQ 401 IGF1R inhibitor,potent and cell-permeable PQ 401 Chemical Structure
  56. GC31780 Pralsetinib (Blu667) Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (Blu667) (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively. Pralsetinib (Blu667) Chemical Structure
  57. GC32802 PRN1371 An irreversible pan-FGFR inhibitor PRN1371 Chemical Structure
  58. GC30502 PRN694

    PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor with IC50s of 0.3 nM and 1.4 nM, respectively.

     PRN694 Chemical Structure
  59. GC46208 Propentofylline

    HOE 285, HWA 285

     A xanthine derivative and neuroprotective agent Propentofylline Chemical Structure
  60. GC36985 PROTAC FAK degrader 1 PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based focal adhesion kinase (FAK) degrader with an IC50 of 6.5 nM, DC50 of 3 nM. PROTAC FAK degrader 1 Chemical Structure
  61. GC65555 PROTAC FLT-3 degrader 1 PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. PROTAC FLT-3 degrader 1 Chemical Structure
  62. GC62197 PROTAC IRAK4 degrader-1 PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively. PROTAC IRAK4 degrader-1 Chemical Structure
  63. GC69769 Protein kinase inhibitor 1 hydrochloride

    Protein kinase inhibitor 1 hydrochloride is an effective inhibitor of HIPK2, with IC50 values of 136 and 74 nM for HIPK1 and HIPK2 respectively, and a Kd value of 9.5 nM for HIPK2.

     Protein kinase inhibitor 1 hydrochloride Chemical Structure
  64. GC34131 Protein kinase inhibitors 1 Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. Protein kinase inhibitors 1 Chemical Structure
  65. GC61217 Protein kinase inhibitors 1 hydrochloride Protein kinase inhibitors 1 hydrochloride is a potent HIPK2 inhibitor, with IC50s of 136 and 74 nM for HIPK1 and HIPK2, and a Kd of 9.5 nM for HIPK2. Protein kinase inhibitors 1 hydrochloride Chemical Structure
  66. GC11321 PRT-060318

    P142-76, PRT318

     novel Syk inhibitor PRT-060318 Chemical Structure
  67. GC25787 PRT-060318 2HCl

    PRT318

     PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment. PRT-060318 2HCl Chemical Structure
  68. GC31819 PRT062607 (P505-15)

    P505-15, PRT062607, PRT2607

     PRT062607 (P505-15)(P505-15; PRT-2607; BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70. PRT062607 (P505-15) Chemical Structure
  69. GC10499 PRT062607 Hydrochloride

    PRT 062607 hydrochloride;PRT-062607 hydrochloride

     PRT062607 Hydrochloride Chemical Structure
  70. GC65335 PTC299

    PTC-299

     PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies. PTC299 Chemical Structure
  71. GC32733 Pyrotinib (SHR-1258) Pyrotinib (SHR-1258) (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Pyrotinib (SHR-1258) Chemical Structure
  72. GC32989 Pyrotinib dimaleate (SHR-1258 dimaleate) Pyrotinib dimaleate (SHR-1258 dimaleate) (SHR-1258 dimaleate) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. Pyrotinib dimaleate (SHR-1258 dimaleate) Chemical Structure
  73. GC37047 Pz-1 Pz-1 is a potent RET and VEGFR2 inhibitor with IC50s of less than 1 nM for both wild type kinases. Pz-1 Chemical Structure
  74. GC17615 Quizartinib (AC220)

    AC220

     Quizartinib (AC220) (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib (AC220) inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib (AC220) can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib (AC220) induces apoptosis. Quizartinib (AC220) Chemical Structure
  75. GC33874 R112 A Syk inhibitor R112 Chemical Structure
  76. GC12857 R1530 A multi-kinase inhibitor R1530 Chemical Structure
  77. GC16796 R406 SYK inhibitor,potent and ATP-competitive R406 Chemical Structure
  78. GC15658 R406(free base) Syk inhibitor R406(free base) Chemical Structure
  79. GC17618 R428

    R-428;R 428;BGB324

     R428 (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM. R428 Chemical Structure
  80. GC11811 R788 disodium

    Fostamatinib Disodium Hexahydrate;R 788;R-788

     R788 disodium (R788 Disodium) is the oral prodrug of the active compound R406. R788 disodium Chemical Structure
  81. GC15709 R788 disodium hexahydrate Fostamatinib (R788) disodium hexahydrate is the oral prodrug of the active compound R406. R788 disodium hexahydrate Chemical Structure
  82. GC33271 R916562 R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. R916562 Chemical Structure
  83. GC11140 Radotinib(IY-5511)

    IY-5511

     Bcr-Abl tyrosine kinase inhibitor Radotinib(IY-5511) Chemical Structure
  84. GC15818 RAF265

    CHIR-265;RAF 265;RAF-265;CHIR265

     Multiple intracellular kinases inhibitor RAF265 Chemical Structure
  85. GC19534 Ramucirumab

    LY3009806

    Ramucirumab is a fully human monoclonal antibody (IgG1).

     Ramucirumab Chemical Structure
  86. GC44806 Ras Inhibitory Peptide

    Sos SH3 Domain Inhibitor

     Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras Inhibitory Peptide Chemical Structure
  87. GC10111 Regorafenib

    BAY 73-4506

     A multi-kinase inhibitor Regorafenib Chemical Structure
  88. GC14606 Regorafenib hydrochloride A multi-kinase inhibitor Regorafenib hydrochloride Chemical Structure
  89. GC14534 Regorafenib monohydrate A multi-kinase inhibitor Regorafenib monohydrate Chemical Structure
  90. GC40213 Regorafenib-13C-d3 Regorafenib-13C-d3 is intended for use as an internal standard for the quantification of regorafenib by GC- or LC-MS. Regorafenib-13C-d3 Chemical Structure
  91. GC64895 Regorafenib-d3

    BAY 73-4506-d3

     Regorafenib D3 (BAY 73-4506 D3) is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor tyrosine kinase inhibitor. Regorafenib-d3 Chemical Structure
  92. GC19362 Repotrectinib TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively. Repotrectinib Chemical Structure
  93. GC67917 RET-IN-7 RET-IN-7 Chemical Structure
  94. GC41467 Reveromycin D Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. Reveromycin D Chemical Structure
  95. GC62341 Rezivertinib

    BPI-7711

     Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). Rezivertinib exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib has excellent central nervous system (CNS) penetration and has antitumor activity. Rezivertinib Chemical Structure
  96. GC12038 RG 13022

    Tyrphostin RG13022

     EGFR tyrosine kinase inhibitor RG 13022 Chemical Structure
  97. GC10217 RG-14620

    Tyrphostin RG14620

     inhibitor of epidermal growth factor (EGF) receptor kinase RG-14620 Chemical Structure
  98. GN10784 Rhoifolin

    Apigenin 7-O-Neohesperidoside

     Rhoifolin Chemical Structure
  99. GC69817 Rilotumumab

    AMG 102

    Rilotumumab (AMG 102) is a monoclonal antibody that targets the hepatocyte growth factor (HGF), inhibiting HGF/MET-driven signaling. Rilotumumab has anti-tumor activity and is being studied for use in castration-resistant prostate cancer (CRPC) and solid tumors.

     Rilotumumab Chemical Structure
  100. GC37538 Ripretinib

    DCC-2618

     Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2). DCC-2618 exerts antineoplastic effect and induces apoptosis. Ripretinib Chemical Structure
  101. GC40547 RK-20448 RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2 (IC50s = 0.24, 1.19, 10.74, and 5.85 μM, respectively). RK-20448 Chemical Structure

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