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Home >> Signaling Pathways >> Tyrosine Kinase >> Trk

Trk

Trk is a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.

Products for  Trk

  1. Cat.No. Product Name Information
  2. GC19012 (R)-GNE-140

    ?A TRK kinase (TKI) inhibitor

     (R)-GNE-140 Chemical Structure
  3. GC16853 7,8-Dihydroxyflavone

    7,8-DHF

     Tyrosine kinase receptor B (TrkB) agonist 7,8-Dihydroxyflavone Chemical Structure
  4. GC16604 Altiratinib

    DCC-2701

     c-MET/TIE-2/VEGFR inhibitor Altiratinib Chemical Structure
  5. GC11486 ANA 12 TrkB receptor antagonist ANA 12 Chemical Structure
  6. GC33090 AZ-23 (AZ23) AZ-23 (AZ23) is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. AZ-23 (AZ23) Chemical Structure
  7. GC12186 BDNF (human) activator of TrkB and p75 neurotrophin receptors BDNF (human) Chemical Structure
  8. GC72353 Bedinvetmab Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab Chemical Structure
  9. GC19063 Belizatinib

    TSR-011

     Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase. Belizatinib Chemical Structure
  10. GC32623 CE-245677 CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. CE-245677 Chemical Structure
  11. GC33112 CH7057288 CH7057288 is a potent and selective TRK inhibitor. CH7057288 Chemical Structure
  12. GC13780 Cyclotraxin B TrkB receptor antagonist Cyclotraxin B Chemical Structure
  13. GC62597 DS-1205b free base DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo. DS-1205b free base Chemical Structure
  14. GC73398 ENT-C225 ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 Chemical Structure
  15. GC14476 Entrectinib

    NMS-E628, RXDX-101

     Orally active inhibitor of ALK kinase Entrectinib Chemical Structure
  16. GC72974 Entrectinib-d8

    NMS-E628-d8; RXDX-101-d8

     Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib. Entrectinib-d8 Chemical Structure
  17. GC16343 GNF-5837 Pan-Trk inhibitor GNF-5837 Chemical Structure
  18. GC69185 GNF-8625 monopyridin-N-piperazine hydrochloride

    GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2) is an inhibitor of TRK, as disclosed in patent WO 2020038415 A1.

     GNF-8625 monopyridin-N-piperazine hydrochloride Chemical Structure
  19. GC14123 GW441756 TrkA inhibitor,potent and selective GW441756 Chemical Structure
  20. GC50660 HIOC HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC Chemical Structure
  21. GC11362 K 252a

    SF 2370

     A protein kinase inhibitor K 252a Chemical Structure
  22. GC17835 LM 22A4 tropomyosin-related kinase B (TrkB) agonist LM 22A4 Chemical Structure
  23. GC30770 LM22B-10 An activator of TrkB and TrkC LM22B-10 Chemical Structure
  24. GC36425 LOXO-101 (Larotrectinib)

    ARRY-470, Larotrectinib

     LOXO-101 (Larotrectinib) (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). LOXO-101 (Larotrectinib) Chemical Structure
  25. GC15282 LOXO-101 (Larotrectinib) sulfate LOXO-101 (Larotrectinib) sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). LOXO-101 (Larotrectinib) sulfate Chemical Structure
  26. GC70279 N-Acetyl-5-hydroxytryptamine-d3 N-Acetyl-5-hydroxytryptamine-d3 is the deuterium labeled N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine-d3 Chemical Structure
  27. GC15365 N-Acetylserotonin

    N-Acetyl-5-hydroxytryptamine,NAS

     N-Acetylserotonin is a Melatonin precursor, and that it can potently activate TrkB receptor. N-Acetylserotonin Chemical Structure
  28. GC10720 NTR 368 cytoplasmic peptide of the neurotrophin receptor p75NTR NTR 368 Chemical Structure
  29. GC50346 PF 06273340 Potent and selective pan-Trk inhibitor; peripherally restricted PF 06273340 Chemical Structure
  30. GC70341 PF-06733804 PF-06733804 is a potent pan-Trk inhibitor in cell-based assays withIC50s of 8.4 nM, 6.2 nM and 2.2 nM for TrkA, TrkB and TrkC, respectively. PF-06733804 Chemical Structure
  31. GC70342 PF-06737007 PF-06737007 is a potent pan-Trk inhibitor in cell-based assays withIC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. PF-06737007 Chemical Structure
  32. GC65009 PF-6683324

    Trk-IN-4

     PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays withIC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively. PF-6683324 Chemical Structure
  33. GC19362 Repotrectinib TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively. Repotrectinib Chemical Structure
  34. GC17622 Ro 08-2750

    antagonist of nerve growth factor (NGF)

     Ro 08-2750 Chemical Structure
  35. GC32808 Selitrectinib (LOXO-195)

    Selitrectinib

     Selitrectinib (LOXO-195) (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively. Selitrectinib (LOXO-195) Chemical Structure
  36. GC19332 Sitravatinib

    MGCD-516

     Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/L. Sitravatinib Chemical Structure
  37. GC31676 Tavilermide (MIM-D3)

    MIM-D3

     Tavilermide (MIM-D3) is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic. Tavilermide (MIM-D3) Chemical Structure
  38. GC11496 TLQP 21 TLQP 21 Chemical Structure
  39. GC60372 TrkA-IN-1 TrkA-IN-1 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 of 99 nM in a cell-based assay. TrkA-IN-1 Chemical Structure
  40. GC70064 TrkA-IN-3

    TrkA-IN-3 is an effective and sub-selective TrkA allosteric inhibitor with an IC50 value of 22.4 nM. TrkA-IN-3 exhibits a selectivity for TrkA over TrkB and TrkC by 8000-fold. It can be used in the study of pain.

     TrkA-IN-3 Chemical Structure
  41. GC70065 TrkA-IN-4

    TrkA-IN-4 is an effective and orally active TrkA allosteric inhibitor, which is a precursor of TrkA-IN-3. TrkA-IN-4 exhibits effective anti-injury activity.

     TrkA-IN-4 Chemical Structure
  42. GC15271 Tyrphostin AG 879

    Tyrphostin AG879

     HER2 inhibitor Tyrphostin AG 879 Chemical Structure
  43. GC72770 Utatrectinib

    AZD-7451

     Utatrectinib (AZD-7451) is a potent, selective and orally active Trk inhibitor. Utatrectinib Chemical Structure

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