Rink Amide-MBHA Resin |
| Catalog No.GA10925 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 431041-83-7
Sample solution is provided at 25 µL, 10mM.
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Rink Amide-MBHA resin is less acid sensitive than Rink Amide resin since the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer. Usually the products are detached from the resin using 95%TFA in DCM and scavengers required by the substrate composition. In addition, Rink Amide-MBHA resin is also useful for peptide syntheses. Previous study has recently reported the syntheses of tri-, tetra- and pentapeptides via a solid phase synthesis methodology by using a Rink Amide MBHA resin[1].
Rink Amide-MBHA resin: 4-(2',4'-Dimethoxypheyl-Fmoc-aminomethyl-phenoxy-acetamido- norleucyl-MBHA resin; Substitution: 0.4 - 0.8 mmole/g resin; Bead size 100- 200 mesh (polystyrene- 1% DVB)
Structure:Appication: Using the Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides, substituted benzhydrylamine and benzylamine linkage agents useful for the solid phase peptide synthesis were evaluated for their relative lability toward trifluoroacetic acid. The two most reactive linkage agents studied were compared in the synthesis of two different peptide amides by the N α-9-fluorenylmethyloxycarbonyl protecting group strategy [2].
Reference:
[1] Boussard C, Doyle VE, Mahmood N, Klimkait T, Pritchard M, Gilbert IH. Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure. Eur J Med Chem. 2002;37(11):883-90.
[2] Michael S. Bernatowicz, Scott B. Daniels, Hubert Köster. A comparison of acid labile linkage agents for the synthesis of peptide C-terminal amides. Tetrahedron Letters Volume 30, Issue 35, 1989, Pages 4645–4648
| Cas No. | 431041-83-7 | SDF | |
| Formula | 100-200:mesh,1%DVB | M.Wt | 0.3~0.8mmol/g |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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