Sabeluzole |
| Catalog No.GC70241 |
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 104383-17-7
Sample solution is provided at 25 µL, 10mM.
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Sabeluzole (50 nM, 100 nM; 20 min before cell injury) exhibits protection in glutamate (50 μM)-mediated excitotoxicity in primary culture of cerebellar granule cell[1].
Sabeluzole (50 nM; 7 d) inhibits tau protein level increase induced by glutamate[1].
Sabeluzole (50 nM; 4 d) shows neuroprotective effects in human neuroblastoma cell line SH-SY5Y[1].
Sabeluzole (5 mg/kg, 25 mg/kg; sc; twice dose with 72 h interval) shows positive and memory enhancing properties in habituation amnesia male rats induced with 20 mg/kg Chlordiazepoxide[2].
References:
[1]. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103.
[2]. Hlinák Z,et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl). 1991;104(4):505-9.
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