Seriniquinone (Synonyms: Dinaphthol[2,3-b:2',3'-d]thiophene-5,7,12,13-tetraone) |
| Catalog No.GB40363 |
Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22200-69-7
Sample solution is provided at 25 µL, 10mM.
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Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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