SEW84 |
| Catalog No.GC71198 |
SEW84 is an inhibitor of the Aha1stimulated Hsp90 (ASH) ATPase activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 259089-67-3
Sample solution is provided at 25 µL, 10mM.
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SEW84 (5 μM) shows complete inhibition of ASH activity with an IC50 value of 0.3 μM[1].
SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 values of 1.3 and 0.7 μM, respectively[1].
SEW84 (0-20 μM) inhibits the Hsp90-Dependent folding of firefly luciferase[1].
SEW84 (0, 3, 10, 30 μM; 24 h) specifically clears phosphorylated tau[1].
References:
[1]. Jay K Singh, et al. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6.
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