SKI-I |
| Catalog No.GC66011 |
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines.
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Cas No.: 306301-68-8
Sample solution is provided at 25 µL, 10mM.
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IC50: 1.2 μM (ST-hSK); 11 μM (hERK2)[1]
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].
SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1].
SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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