sn-glycero-3-Phosphocholine-d9 (Synonyms: Glycerophosphocholine-d9, L-α-Glycerophosphorylcholine-d9, L-α-GPC-d9, sn-glycero-3-PC-d9)

sn-glycero-3-Phosphocholine-d₉ is intended for use as an internal standard for the quantification of sn-glycero-3-phosphocholine by GC- or LC-MS. sn-glycero-3-Phosphocholine is a nootropic phospholipid, a precursor to choline biosynthesis, and an intermediate in the metabolism of phosphatidylcholine.¹ In vivo, sn-glycero-3-phosphocholine is converted to phosphorylcholine, a metabolically active form of choline that increases acetylcholine synthesis and release in rat hippocampus. It prevents scopolamine-induced amnesia in a passive avoidance test in rats and exerts neuroprotective effects in models of altered cholinergic neurotransmission and models of brain vascular injury.^1,2

1.Traini, E., Bramanti, V., and Amenta, F.Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipid with a still interesting profile as cognition enhancing agent.Curr. Alzheimer Res.10(10)1070-1079(2013) 2.Sigala, S., Imperato, A., Rizzonelli, P., et al.L-α-glycerylphosphorylcholine antagonizes scopolamine-induced amnesia and enhances hippocampal cholinergic transmission in the ratEur. J. Pharmacol.211(3)351-358(1992)