Sozinibercept |
| Catalog No.GC70936 |
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2568358-31-4
Sample solution is provided at 25 µL, 10mM.
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Sozinibercept inhibits CNV lesion formation and vascular leakage in the mouse laser-induced model of choroidal neovascularization (CNV). Moreover, Sozinibercept exhibits comparable efficacy to Aflibercept in CNV mouse model[1][2].
Sozinibercept (intravitreal injection; once every 4 wk for 4 months) shows selective inhibition of VEGF-C/D, and inhibits diabetic retinal edema induced by streptozotocin (STZ) in the rat model, and equivalent to inhibition of VEGF-A inhibitor (Aflibercept)[3].
References:
[1]. Lashkari K, et al. VGX-300, a ‘Trap’for VEGF-C and VEGF-D, Inhibits Choroidal Neovascularization and Vascular Leakage in a Mouse Model of Wet AMD[J]. Investigative Ophthalmology & Visual Science, 2015, 56(7): 4802-4802.
[2]. Lashkari K, et al. VEGF-C and VEGF-D Blockade by VGX-300 Inhibits Choroidal Neovascularization and Leakage in a Mouse Model of wet AMD[J]. Investigative Ophthalmology & Visual Science, 2014, 55(13): 1823-1823.
[3]. Turunen T, et al. VEGF-C and VEGF-D Inhibition by VGX-300 Effectively Reduces Leukocyte Adhesion and Vascular Leakage in the STZ-Rat Model of Diabetic Retinal Edema[J]. Investigative Ophthalmology & Visual Science, 2019, 60(9): 3667-3667.
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