11-deoxy-11-methylene-15-keto Prostaglandin D2 (Synonyms: 11deoxy11methylene15keto PGD2) |
| Catalog No.GC41879 |
Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.
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Cas No.: 958759-75-6
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. Many of the biological effects of PGD2 are transduced in vivo by a classical 7-transmembrane GPCR, the DP1 receptor. However, a second receptor, the chemokine-related CRTH2 receptor, also binds PGD2. This new receptor was recently identified on human eosinophils, where it binds selectively the PGD2 metabolite 13,14-dihydro-15-keto PGD2. 11-deoxy-11-methylene-15-keto PGD2 was prepared as a more chemically stable ligand for this receptor. There are no published studies of the pharmacological properties of 11-deoxy-11-methylene-15-keto PGD2.
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