15-Acetyldeoxy Nivalenol (Synonyms: 15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate) |
| Catalog No.GC19442 |
El 15-acetildeoxi nivalenol es un tricoteceno altamente tóxico que se encuentra en los cereales y un metabolito del deoxinivalenol que presenta toxicidad para las células HepG2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 88337-96-6
Sample solution is provided at 25 µL, 10mM.
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15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops. It is an acetylated derivative of 4-deoxy nivalenol that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration. It also changes brain bioamine neurotransmitter levels in pigs and chickens.
References:
[1].Ajandouz, E.H., Berdah, S., Moutardier, V., et al. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: Specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches Toxins (Basel) 8(8), E232 (2016).
[2]. Pestka, J.J., Lin, W.-S., and Miller, E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine Food Chem. Toxicol. 25(11), 855-888 (1987).
[3].Payros, D., Alazzane-Kpembi, I., Pierron, A., et al. Toxicology of deoxynivalenol and its acetylated and modified forms Arch. Toxicol. 90(12), 2931-2957 (2016).
[4].Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target Toxins (Basel) 4(11), 1120-1138 (2012).
| Cas No. | 88337-96-6 | SDF | |
| Sinónimos | 15-Acetyl Vomitoxin, 15-AcDON, Deoxynivalenol 15-acetate, DON 15-acetate | ||
| Canonical SMILES | CC1=C[C@]2([H])[C@]([C@](C[C@H]3O)(C)C4(OC4)[C@]3([H])O2)(COC(C)=O)[C@H](O)C1=O | ||
| Formula | C17H22O7 | M.Wt | 338.4 |
| Solubility | Chloroform: soluble,Ethanol: soluble | Storage | Store at -20°Cprotect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL |
| 5 mM | 0.591 mL | 2.9551 mL | 5.9102 mL |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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